Calcium-mingled tantalum oxide nanometer bar structure biological activity coating and preparation method thereof

A bioactive, nanorod technology, applied in the field of bioactivation modification of medical metal surfaces, can solve the problems of difficult porous material coating preparation, poor adhesion between the coating and the substrate, etc., to promote adhesion and proliferation, and good binding ability. , the effect of simple ingredients

Inactive Publication Date: 2019-05-07
SHAANXI UNIV OF SCI & TECH
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  • Claims
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Problems solved by technology

Ta 2 o 5 It has made an important contribution to the corrosion resistance of the tantalum metal surface, but I want to prepare Ta on the tantalum surface 2 o 5 There are methods such as anodic oxidation and magnetron sputtering for nanostructure characteristic coatings, but the anodic oxidation method has the problem of poor bonding between the coating and the substrate. The magnetron sputtering method is a linear technology, and it is not easy to achieve coatings inside porous materials. preparation

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  • Calcium-mingled tantalum oxide nanometer bar structure biological activity coating and preparation method thereof
  • Calcium-mingled tantalum oxide nanometer bar structure biological activity coating and preparation method thereof
  • Calcium-mingled tantalum oxide nanometer bar structure biological activity coating and preparation method thereof

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preparation example Construction

[0026] A method for preparing a calcium-doped tantalum oxide nanorod structure bioactive coating, comprising the following steps:

[0027] 1) Primary hydrothermal treatment of tantalum:

[0028] With 0.2~0.4mol / L HF and 1~2mol / L H 2 o 2 Prepare a hydrothermal solution with a certain molar concentration, pour it into a hydrothermal reaction kettle, the filling degree of the solution is 40%-60%, soak the tantalum sample in the solution, and treat it under the condition of 220-240°C for 12-24 hours. , the tantalum oxide nanorod structure coating can be obtained on the surface of the tantalum base, that is, the processed tantalum sample can be obtained;

[0029] 2) Secondary hydrothermal treatment of tantalum oxide nanorod structure coating:

[0030] Inject the calcium acetate solution with a concentration of 0.001-0.1mol / L into the hydrothermal reaction kettle, the filling degree of the solution is 40%-60%, and soak the treated tantalum sample into the calcium-containing solut...

Embodiment 1

[0034] With 0.2mol / L HF and 1mol / L H 2 o 2 Prepare a hydrothermal solution with a molar concentration of 220°C for 24 hours, inject it into a hydrothermal reaction kettle, and the filling degree of the solution is 60%. A tantalum oxide nanorod structure coating is obtained, the microstructure of the coating is in the shape of upright nanorods, the average diameter of the nanorods is 28 nanometers, the length of the nanorods is about 100-200 nanometers, and the roughness Ra is about 96.3±9.5 nanometers.

[0035] Inject the calcium acetate solution with a concentration of 0.001mol / L into the hydrothermal reaction kettle, and the filling degree of the solution is 60%, and soak the tantalum-based sample covered with the coating of tantalum oxide nanorods into the calcium acetate solution at 200°C The calcium-doped tantalum oxide nanorod structure coating can be obtained on the tantalum surface by hydrothermally treating it for 2 hours under certain conditions. The microstructure...

Embodiment 2

[0037] With 0.2mol / L HF and 1mol / L H 2 o 2 Prepare a hydrothermal solution with a molar concentration of 220°C for 24 hours, inject it into a hydrothermal reaction kettle, and the filling degree of the solution is 60%. A tantalum oxide nanorod structure coating is obtained, the microstructure of the coating is in the shape of upright nanorods, the average diameter of the nanorods is 28 nanometers, the length of the nanorods is about 100-200 nanometers, and the roughness Ra is about 96.3±9.5 nanometers.

[0038]Inject the calcium acetate solution with a concentration of 0.01mol / L into the hydrothermal reaction kettle, the filling degree of the solution is 60%, and soak the tantalum-based sample covered with the coating of tantalum oxide nanorods into the calcium acetate solution, at 200°C The calcium-doped tantalum oxide nanorod structure coating can be obtained on the tantalum surface by hydrothermally treating it for 2 hours under certain conditions. The microstructure of t...

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Abstract

The invention discloses a calcium-mingled tantalum oxide nanometer bar structure biological activity coating and a preparation method thereof. According to the method, at first, a water solution containing hydrofluoric acid and hydrogen peroxide serves as a water heat solution, different water heat conditions are adopted for carrying out water heat treatment on a tantalum base body, then a tantalum oxide nanometer bar structure coating obtained again is subjected to water heat treatment under the calcium-contained water heat environment condition, the obtained coating microstructure is of a nanometer bar shape, the phase is tantalum pentoxide, and the nanometer bar structure coating is mingled with a calcium element. The high combination strength between the calcium-mingled nanometer bar structure coating and the base body is achieved, the calcium element separated out from the coating is increased gradually along with prolonging of soaking time, bone apatite can be induced and formedrapidly in the liquid-like environment, and the coating has good biological activity.

Description

technical field [0001] The invention belongs to the technical field of biological activation and modification of medical metal surfaces, and relates to a preparation technology of a bioactive coating on the surface of a tantalum-based medical implant, in particular to a calcium-doped tantalum oxide nanorod structure bioactive coating and its preparation method. Background technique [0002] Compared with existing hard tissue implant materials such as titanium and titanium alloys, zirconium, and magnesium alloys, tantalum has broad application prospects in the fields of bone substitutes and dental implants due to its excellent corrosion resistance and biocompatibility. In recent years, the development of porous tantalum with low elastic modulus, high volume porosity and high friction coefficient has made tantalum more important in spinal intervertebral fusion, hip or knee replacement, and treatment of femoral head necrosis. potential. However, as an inert metal, tantalum is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/54C23C22/83A61L27/30A61L27/50
Inventor 王翠翠李新宇童晨光殷海荣郭宏伟张森李明阳高杨
Owner SHAANXI UNIV OF SCI & TECH
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