Bionic polymer and method for preparing durable double-bionic polymer coating and application thereof

A polymer coating and polymer technology, which is applied in coatings, biocide-containing paints, antifouling/underwater coatings, etc., can solve the problems of large polydopamine aggregate size, heavy coating color, and limited applications , to achieve the effects of good anti-biological pollution performance and bactericidal performance, improved coating stability, and simple and easy preparation method

Active Publication Date: 2019-05-24
NORTHWEST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above-mentioned coating preparation method is relatively cumbersome, and due to the relatively large size of polydopamine aggregates, the coating color is heavy, and...

Method used

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  • Bionic polymer and method for preparing durable double-bionic polymer coating and application thereof
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  • Bionic polymer and method for preparing durable double-bionic polymer coating and application thereof

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preparation example Construction

[0046] The preparation method of durable double biomimetic polymer coating of the present invention comprises the following steps:

[0047] Step 1, preparation of biomimetic polymers:

[0048] A1: According to the mole percentage, (1~90): (9~60): (1~70) will respectively contain the (meth)acrylic acid of zwitterionic group W, amino hydrochloride S and quaternary ammonium cationic group T The ester monomer is dissolved in the solvent, the mass percentage of the (meth)acrylate monomer and the solvent is (4-20): (80-96), and the monomer mixture is obtained;

[0049] B1: According to the mass percentage of initiator and (meth)acrylate monomer (0.1-5.0): (95.0-99.9), the initiator is dissolved in the solvent to obtain an initiator solution;

[0050] C1: Mix the monomer mixed solution and the initiator solution according to the mass percentage of (70-95): (5-30), mix them evenly, transfer them to the constant pressure dropping funnel, and use 20%-50% / The feed rate of 1 hour is ad...

Embodiment 1

[0063] (Meth)acrylic acid ester copolymer (1 ) preparation:

[0064] With 2-methacryloyloxyethylphosphorylcholine (MPC), 2-aminoethylmethacrylate hydrochloride (AEMA) and methacryloyloxyethyltrimethylammonium chloride (TMA) as monomer, potassium persulfate (K 2 S 2 o 8 ) is a free radical initiator; take by weighing 5.31g (18mmol) MPC, 1.85g (11mmol) AEMA and 1.48g (7mmol) TMA respectively according to MPC, AEMA and TMA mole percentage feed ratio 50:30:20, then according to mass percentage Dissolve three kinds of (meth)acrylate monomers in deionized water at a ratio of 4:96 to obtain a monomer mixture; weigh 0.08541 g of Potassium sulfate is dissolved in deionized water to obtain an initiator solution; the monomer mixed solution and the initiator solution are mixed uniformly according to the mass percentage of 80:20, and transferred to a constant pressure dropping funnel. In a three-necked bottle equipped with a thermometer and a constant pressure dropping funnel, add 20 ...

Embodiment 2

[0066] Using the same polymerization method as in Example 1, with MPC, N-(3-aminopropyl) methacrylic acid hydrochloride (DPMA) and methacryloxyethyl dimethyl benzyl ammonium chloride (BDA) As a monomer, prepare a (meth)acrylic ester biomimetic polymer (2) containing phosphorylcholine zwitterions, amino hydrochloride and dimethyl benzyl ammonium chloride cations in side groups, only MPC, DPMA and BDA The molar percentage feeding ratio is 90:9:1, and the feeding amount is respectively 5.38g (18mmol) MPC, 0.36g (1.8mmol) DPMA and 0.06g (0.2mmol) BDA, and then three kinds of (formazan Base) acrylate monomer was dissolved in ethanol to obtain a monomer mixture; according to the mass percentage of initiator and (meth)acrylate monomer being 0.1:99.9, 0.0064g of azobisisobutyronitrile was weighed and dissolved in ethanol , to obtain an initiator solution; the monomer mixed solution and the initiator solution were mixed uniformly according to the mass percentage of 70:30, and transferr...

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Abstract

The invention discloses a bionic polymer, a method for preparing a durable double-bionic polymer coating and an application thereof, wherein the method comprises the following steps: the bionic polymer with side groups containing zwitterionic groups W, amino hydrochloride S and quaternary ammonium cation groups T and dopamine are dissolved in a solvent in sequence to prepare a polymer-dopamine alkalescent aqueous solution, then the different substrates are in the polymer-dopamine alkalescent aqueous solution, and the durable double-bionic polymer coating is obtained by leaching and drying. Theobtained coating has the advantages of high light transmittance, good hydrophilicity, strong universal base material, excellent coating stability, good biomolecule adhesion resistance and antibacterial performance, and simple preparation process; one-step dipping and coating method is convenient and efficient, green and mild property; the surface of the material has the advantages of long-term biological pollution resistance, bacterial infection resistance and high biocompatibility; the coating is suitable for coating the surfaces of medical equipment, diagnosis and treatment instruments, implants, drug delivery systems, contact lenses, corneal shaping lenses and the like with various shapes and materials and high light transmittance requirements.

Description

technical field [0001] The invention relates to the technical fields of polymer chemistry and physics, surface science and biomedical materials, in particular to a biomimetic polymer and a method and application for making a durable double biomimetic polymer coating. Background technique [0002] With the wide application of medical equipment, diagnostic equipment, and implants in various shapes and materials, the related bacterial infection has become one of the clinical problems to be solved urgently. Bacterial adhesion to the material surface is the initial cause of this type of infection, and the amount of bacterial adhesion is closely related to the charge properties, hydrophilicity / hydrophobicity, chemical composition, and presence or absence of biological contamination layers on the surface of the material. A large number of studies have shown that the hydrophilic coating rich in zwitterions (electrically neutral), because it has a surface imitating the outer membrane...

Claims

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Application Information

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IPC IPC(8): C08J7/04C08F230/02C08F220/36C08F220/34C08G73/06C09D143/02C09D133/14C09D5/14C09D5/16C08L23/12C08L27/18C08L69/00C08L83/04
Inventor 史素青赵洋张喜婷师欢陈杰范蓉瑾宫永宽
Owner NORTHWEST UNIV
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