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Microcapsule containing natural astaxanthin ester and preparation method thereof

A technology of astaxanthin esters and microcapsules, which is applied in the field of microcapsules containing natural astaxanthin esters and its preparation, can solve the problems of poor stability of microcapsules, large particles of astaxanthin microcapsules, and poor capsule stability, and achieve Improve the absorption rate in vivo, improve the storage stability, and the effect of good fluidity

Inactive Publication Date: 2019-05-31
睿藻生物科技(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The Chinese Invention Patent No. 201210561599.7, which was applied for on December 22, 2012, provides a method for preparing astaxanthin microcapsules, but the astaxanthin microcapsules produced by this method have large particles and poor water dispersibility, and shrimp The embedding rate of cyanine is low, and the stability of the formed microcapsules is poor
[0004] The Chinese Invention Patent No. 200810244049.6, which was applied for on December 19, 2008, also provides a method for preparing astaxanthin microcapsules, but the microcapsules produced by this method have low astaxanthin content and poor stability of the capsules
[0005] The Chinese patent No. 201510152395.1, filed on April 2, 2015, provides another preparation method of astaxanthin microcapsules. This method slightly improves the particle size and water dispersibility of the capsules, but also contains Problems of low embedding rate and poor stability of microcapsules

Method used

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  • Microcapsule containing natural astaxanthin ester and preparation method thereof
  • Microcapsule containing natural astaxanthin ester and preparation method thereof
  • Microcapsule containing natural astaxanthin ester and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Mix 50g of olive oil with 50g of glycerin and heat to 50°C, dissolve 15g of Haematococcus pluvialis extract (ie, astaxanthin ester) (astaxanthin content is 33.2% based on free astaxanthin), and then add 12g soybean lecithin, 2g tocopherol, 2g glyceryl laurate and dissolved to form an oil phase containing astaxanthin ester. Dissolve 3 g sucrose laurate, 3 g sorbitol, 2 g polyglyceryl-10 laurate, 1 g sodium ascorbate, 5 g gum arabic, 95 g maltodextrin, 100 g sodium starch octenyl succinate in 670 g water to form the aqueous phase .

[0050] The oil phase was mixed with the water phase, and the mixture was first made into a coarse emulsion using a high-speed shear emulsifier (Wiggens, D-500, China), and then a high-pressure homogenizer (ATS, AH-NANO, China) was used to make an emulsion.

[0051] The above emulsion was dried by spray drying method (Yacheng, YC-501, China; inlet air temperature 120°C, outlet air temperature 80°C) with nitrogen as drying gas and made into mi...

Embodiment 2

[0054] After mixing 45g safflower seed oil with 30g glycerol palmitate, heat it to 50°C, add 10g (astaxanthin content is 33.2% according to free astaxanthin) extract of Haematococcus pluvialis (ie astaxanthin ester ) is dissolved, then add 12g soybean lecithin, 2g tocopherol and dissolve to form an oil phase containing astaxanthin ester. 2g sucrose laurate, 1g sorbitol, 1g polyglycerol-10 laurate, 1g sodium ascorbate, 5g guar gum, 50g calcium caseinate, 40g water-soluble chitosan, 100g maltodextrin were dissolved in 700 g of water to form the aqueous phase.

[0055] The oil phase was mixed with the water phase, and the mixture was first made into a coarse emulsion using a high-speed shear emulsifier (Wiggens, D-500, China), and then a high-pressure homogenizer (ATS, AH-NANO, China) was used to make an emulsion.

[0056] The above emulsion was dried by spray drying method (Yacheng, YC-501, China; inlet air temperature 120°C, outlet air temperature 80°C) with nitrogen as drying...

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Abstract

The invention discloses a microcapsule containing natural astaxanthin ester and a preparation method thereof. The microcapsule comprises a capsule wall material and an oil phase which is wrapped by the capsule wall material and contains natural astaxanthin ester. The capsule wall material includes a main ingredient and an auxiliary ingredient, the main ingredient is one or more of glue, polysaccharide, glycan, protein and peptide, and the auxiliary ingredient is one or more of sucrose ester, polyalcohol aliphatic ester, ascorbic acid and salts thereof, erythorbic acid and salts thereof, ethylenediamine tetraacetic acid and natural polyphenol. The oil phase includes natural astaxanthin ester, fat, oil, phospholipid, polyalcohols and a stabilizer. The preparation method is high in embeddingrate, can remarkably improve the storage stability of natural astaxanthin ester, has the good flowability, and can remarkably improve the living body absorption rate of natural astaxanthin ester. Themicrocapsule can be applied to products of food, beverages, cosmetics, skincare products, medicines and the like.

Description

technical field [0001] The invention belongs to the technical field of biological material preparation, and in particular relates to a microcapsule containing natural astaxanthin ester and a preparation method thereof. Background technique [0002] Natural astaxanthin is the strongest antioxidant currently known and can be used as a new type of active factor in food, beverages, cosmetics, skin care products, and medicines. Therefore, natural astaxanthin has huge market potential. Astaxanthin is widely found in animals and plants, but untreated natural astaxanthin mainly exists in the form of oil-soluble astaxanthin ester, which has very poor water solubility. At the same time, it acts as a strong antioxidant. Esters are easily oxidatively degraded and lose their activity when stored under normal conditions. The microcapsules can wrap the active substance in a protective layer formed by the wall material, which isolates the active substance from contact with the external en...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/44A61K47/10A61K47/24A61K47/22A61K47/14A61K47/26A61K47/36A61K47/42A61K31/225A61P39/06A61K8/37A61K8/11A61K8/92A61K8/34A61K8/55A61K8/67A61K8/60A61K8/39A61K8/73A61K8/64A61Q19/08A23L33/115A23P10/30
Inventor 李彤徐耀刚吕朕晨
Owner 睿藻生物科技(苏州)有限公司
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