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A kind of enrofloxacin quick-release pellets and preparation method thereof

A technology of enrofloxacin and immediate release, which is applied in the field of enrofloxacin immediate-release pellets and its preparation, can solve the problems of poor oral palatability of enrofloxacin powder, increase absorption and utilization time, expand production capacity, and achieve The effect of short peak times

Active Publication Date: 2021-05-18
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention designs and develops a kind of enrofloxacin quick-release pellets, which solves the problem of poor oral palatability of enrofloxacin powder, does not affect animal feed intake, improves the bioavailability of the drug in animals, and better meets modern requirements. Breeding needs

Method used

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  • A kind of enrofloxacin quick-release pellets and preparation method thereof
  • A kind of enrofloxacin quick-release pellets and preparation method thereof
  • A kind of enrofloxacin quick-release pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Table 1 10% content specification prescription

[0034] Name of raw material Addition g Enrofloxacin 10g (converted content) dextrin 2g Croscarmellose Sodium 2g sucrose 10g starch added to 90g 2% pvpk30 aqueous solution 60ml 10% hypromellose solution 50ml Titanium dioxide 2.0g polyethylene glycol 400 3.0g water 80ml

[0035] Preparation process

[0036] (1) Take enrofloxacin, dextrin, sucrose, starch and cross-linked sodium carboxymethyl cellulose and mix uniformly by prescription quantity;

[0037] (2) Weigh the pvpk30 component and throw it into purified water, and dissolve it by shearing for 15 minutes to obtain a binder solution;

[0038] (3) Put the powder in step 1 into the tank mixer machine, mix with the binder in step 2 to prepare soft material, and discharge;

[0039] (4) Add the soft material prepared in step 3 to the spherical extruder and spheronizer for 35 rotations and extrude,...

Embodiment 2

[0044] Table 2 20% content specification prescription

[0045] Name of raw material Addition g Enrofloxacin Hydrochloride 20g (converted content) lactose 40g Crospovidone 3g starch added to 95g water 70ml Acrylic resin emulsion (gastric disintegration) 2 silica 2.0g Triacetin 1.0g ethanol 80ml

[0046] Preparation process

[0047] (1) Take enrofloxacin hydrochloride, crospovidone, lactose and starch by prescription and mix evenly;

[0048] (2) Put the powder in step 1 into the tank mixer machine, add water and mix to prepare soft material, and discharge;

[0049] (3) Add the soft material prepared in step 2 to a spherical extruder for 45 rotations to extrude, and spheronize in a spheronizer at 600 rotations for 60 seconds, and dry the prepared ball cores in a fluidized bed at 60 degrees for 1 hour;

[0050] (4) Screen the dried material, get the material between 20 and 60 mesh, and set aside;

[0051] (5...

Embodiment 3

[0054] Table 3 10% content specification prescription

[0055] Name of raw material Addition g Enrofloxacin Hydrochloride 5g (converted content) Enrofloxacin 5 (converted content) microcrystalline cellulose 40g Low Substituted Hydroxypropyl Methyl Cellulose 3g starch added to 90g water 70ml Acrylic resin emulsion (gastric disintegration) 7g talcum powder 2.0g triethyl citrate 1.0g ethanol 80ml

[0056] Preparation process

[0057] (1) Take enrofloxacin, enrofloxacin hydrochloride, low-substituted hypromellose, microcrystalline cellulose and starch by weighing and mixing uniformly according to the prescription quantity;

[0058] (2) Put the powder in step 1 into the tank mixer machine, add water and mix to prepare soft material, and discharge;

[0059] (3) Add the soft material prepared in step 2 to a spherical extruder for 45 rotations to extrude, and spheronize in a spheronizer at 600 rotations for 6...

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Abstract

An enrofloxacin immediate-release pellet relates to the field of veterinary medicine. The pellet core is composed of the following components by weight percentage: 10%-45% of enrofloxacin, 18%-86% of excipient, disintegrating 1% to 5% of disintegrating agent, 1% to 2% of binder; the coating solution has a weight gain of 2% to 30%. In addition, it also relates to the preparation method of the enrofloxacin immediate-release pellets. The invention can cover up the bitter taste of enrofloxacin, ensure the rapid disintegration and release of the preparation in the gastrointestinal tract, and simplifies the prescription compared with the commercially available preparations. There are few types of auxiliary materials, which reduces the preparation quality problem caused by uneven mixing of raw and auxiliary materials in the preparation process, and the preparation process is simple, the quality is stable and reliable, and the bioavailability of the drug in the animal body is significantly improved.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to veterinary drugs, in particular to an enrofloxacin quick-release pellet and a preparation method thereof. Background technique [0002] Enrofloxacin is a third-generation fluoroquinolone drug specially used for animals. It has the characteristics of broad antibacterial spectrum, strong bactericidal activity, wide distribution in the body, unique antibacterial effect, high bioavailability, small toxic and side effects, and no cross-resistance. It is still widely used in clinical veterinary medicine, favored by the veterinary field, and widely used in Europe, the United States and other countries. Clinically, it is mainly used to treat diseases caused by Gram-negative bacteria, mycoplasma, rickettsia and certain facultative anaerobic bacteria infections in pigs, cattle, sheep and other animals. At present, the pharmacokinetics of enrofloxacin has been widely studied, including p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/38A61K31/496A61P31/04
CPCA61K9/5042A61K31/496A61P31/04
Inventor 聂丽娜李雪娇曹春芳夏雪林刘爱玲李守军吴燕子
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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