Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of voglibose tablet and preparation method thereof

A technology for voglibose and sugar tablets, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of low dissolution and uniform content of voglibose tablets. It can protect the gastric mucosa, take it easily, and increase the absorption points.

Active Publication Date: 2021-06-04
JIANGSU CHENPAI PHARM GRP CO LTD
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a voglibose tablet and a preparation method thereof, which solves the problems of low dissolution rate, poor content uniformity, unstable properties, and high dissolution rate and uniformity of the voglibose tablet in the background technology. Problems causing gastric mucosal damage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of voglibose tablet and preparation method thereof
  • A kind of voglibose tablet and preparation method thereof
  • A kind of voglibose tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The voglibose tablet of this embodiment includes the following raw materials: 13 parts of voglibose, 480 parts of lactose, 45 parts of microcrystalline cellulose, 47 parts of hydroxypropyl cellulose, 120 parts of crospovidone, hard 6 parts of magnesium fatty acid, 5 parts of polysorbate 80, 16 parts of micropowdered silica gel, 11 parts of xanthan gum, 28 parts of magnesium carbonate, 16 parts of isopropylene glycol, 17 parts of carboxymethyl cellulose calcium, 17 parts of sodium alginate, hydrogenated 28 parts of phospholipids, 23 parts of vitamin E ester, 10 parts of sodium hydroxide, 9 parts of potassium hydroxide, 7 parts of povidone K30.

[0025] The preparation method of the voglibose tablet of the present embodiment comprises the following steps:

[0026] 1) Premixing: Pass lactose, microcrystalline cellulose, hydroxypropyl cellulose and crospovidone through a 100-mesh sieve respectively, weigh lactose, microcrystalline cellulose, hydroxypropyl cellulose and cros...

Embodiment 2

[0032] The voglibose tablet of this embodiment includes the following raw materials: 11 parts of voglibose, 475 parts of lactose, 50 parts of microcrystalline cellulose, 50 parts of hydroxypropyl cellulose, 150 parts of crospovidone, hard 7 parts of magnesium fatty acid, 10 parts of polysorbate 80, 7 parts of micronized silica gel, 20 parts of fucus, 27 parts of magnesium carbonate, 20 parts of isopropylene glycol, 15 parts of carboxymethyl cellulose calcium, 14 parts of sodium alginate , 30 parts of hydrogenated phospholipids, 25 parts of vitamin E ester, 13 parts of sodium hydroxide, 10 parts of potassium hydroxide, 6 parts of povidone K30.

[0033] The preparation method of the voglibose tablet of the present embodiment comprises the following steps:

[0034] 1) Premixing: Pass lactose, microcrystalline cellulose, hydroxypropyl cellulose and crospovidone through a 100-mesh sieve respectively, weigh lactose, microcrystalline cellulose, hydroxypropyl cellulose and crospovidon...

Embodiment 3

[0040] The voglibose tablet of this embodiment includes the following raw materials: 10 parts of voglibose, 470 parts of lactose, 49 parts of microcrystalline cellulose, 45 parts of hydroxypropyl cellulose, 130 parts of crospovidone, hard 6 parts of magnesium fatty acid, 10 parts of polysorbate 80, 10 parts of micropowdered silica gel, 15 parts of xanthan gum and fucus, 23 parts of magnesium carbonate, 17 parts of isopropylene glycol, 19 parts of carboxymethylcellulose calcium, 10 parts of sodium alginate, 25 parts of hydrogenated phospholipids, 22 parts of vitamin E ester, 11 parts of sodium hydroxide, 7 parts of potassium hydroxide, and 5 parts of povidone K30.

[0041] The preparation method of the voglibose tablet of the present embodiment comprises the following steps:

[0042] 1) Premixing: Pass lactose, microcrystalline cellulose, hydroxypropyl cellulose and crospovidone through a 100-mesh sieve respectively, weigh lactose, microcrystalline cellulose, hydroxypropyl cell...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a voglibose tablet and a preparation method thereof, comprising the following raw materials: voglibose, lactose, microcrystalline cellulose, hydroxypropyl cellulose, crospovidone and magnesium stearate , polysorbate 80, micropowder silica gel, macromolecular polysaccharide, magnesium carbonate, isopropylene glycol, carmellose calcium, sodium alginate, hydrogenated phospholipids, vitamin E ester, sodium hydroxide, potassium hydroxide, povidone K30, Using a new raw material formula, setting a high-quality ratio, and setting process parameters, etc., the obtained voglibose tablets have good dissolution rate and content uniformity, and while ensuring high dissolution rate and uniformity, it will not Causing gastric mucosal damage can better exert the efficacy of voglibose tablets and improve its drug efficacy.

Description

technical field [0001] The invention belongs to the technical field of voglibose, in particular to a voglibose tablet and a preparation method thereof. Background technique [0002] Voglibose is an α-glucosidase inhibitor. Its mechanism of action is to competitively inhibit maltase, isomaltase, glycosidase, etc. on the intestinal mucosa to reduce the decomposition of disaccharides to monosaccharides. It leads to a reduction in the formation of D-glucose, thereby delaying the digestion and absorption of starch and sucrose, lowering blood sugar, and especially controlling postprandial hyperglycemia. Voglibose has a stable hypoglycemic effect and does not stimulate the secretion of insulin. There is no hyperinsulinemia after meals, and hypoglycemia is not easy to occur. [0003] Although voglibose has good water solubility, because its crystal form is needle-like in a matrix, it dissolves slowly when it encounters a dissolution medium and takes a long time to take effect. At ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/02A61K47/32A61K47/36A61K47/38A61K47/12A61K47/10A61K47/26A61K47/04A61K47/24A61K47/22A61K31/133A61P3/10
CPCA61K9/2009A61K9/2013A61K9/2018A61K9/2027A61K9/205A61K9/2054A61K9/2095A61K31/133A61P3/10
Inventor 李建新陈泳海
Owner JIANGSU CHENPAI PHARM GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com