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A kind of biosensor and preparation method thereof

A technology of biosensors and biomolecules, which is applied in the field of biosensors based on self-assembled quantum dot ring core cavity and its preparation, can solve the problems of poor stability of the test system, weak integration, low detection efficiency, etc., and achieve anti- Strong electromagnetic interference, strong flexibility, good safety effect

Active Publication Date: 2022-07-08
BEIFANG UNIV OF NATITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the existing technology uses the principle that the hydroxyl group on the surface of the microcavity of the silica material will undergo an adsorption reaction after being treated with a silane coupling agent and an alkaline environment to change the effective refractive index of the optical microcavity mode, but the microcavity material used Silica is a passive material, which needs to be coupled with tapered optical fiber during the test, the test system has poor stability, poor integration, and low detection efficiency

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  • A kind of biosensor and preparation method thereof
  • A kind of biosensor and preparation method thereof
  • A kind of biosensor and preparation method thereof

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Effect test

Embodiment 1

[0040] like figure 2 As shown, a quantum dot gain medium-based biosensor includes a low-refractive-index substrate and a ring-core cavity formed by curing on the substrate, and the material of the ring-core cavity is functionalized that can adsorb biomolecules Quantum dot gain medium material. The substrate of the biosensor and the ring-core cavity form a whispering gallery mode optical microcavity, and the ring-core cavity structure will adsorb the biological detection target, resulting in a change in the equivalent refractive index of the microcavity mode, which in turn causes the ring-core cavity excitation. The emission wavelength shifts, and finally the detection of the specific biological target concentration is realized.

[0041] The choice of functionalized (that is, surface-modified with specific molecules) quantum dot gain medium is on the one hand to obtain the active material required for biosensors, and on the other hand, it can be used as an absorber layer for sp...

Embodiment 2

[0049] A biosensor based on polymer-doped quantum dot gain medium mixing, the substrate of which is a low-refractive-index quartz glass substrate, and the material of the ring core cavity is polymer-doped quantum dot gain medium material.

[0050] like figure 1 As shown in the figure, the above-mentioned method for fabricating a biosensor based on polymer-doped quantum dot gain medium mixing, the specific steps are as follows:

[0051] S1. Select a 3cm×3cm quartz glass sheet as the substrate, and wash with a mixed solution of concentrated sulfuric acid and hydrogen peroxide at 60° C. for 10 minutes.

[0052] S2. Disperse the functionalized colloidal core-shell quantum dots CdSe-ZnS in a toluene solvent at a concentration of 30 mg / mL. The FCV (polyacrylpyrrole) solution with a mass fraction of 1% is prepared, and then the quantum dot solution and the FCV solution are mixed in a volume ratio of 1:1 to complete the preparation of the polymer-doped quantum dot gain medium mixed s...

Embodiment 3

[0057] A biosensor based on polymer-doped quantum dot gain medium hybrid, comprising a low-refractive-index quartz glass substrate and two coupled ring-core cavities, wherein the material of the ring-core cavity is polymer-doped quantum Point gain medium material.

[0058] The above-mentioned manufacturing method of biosensor based on polymer-doped quantum dot gain medium mixing, the specific steps are as follows:

[0059] S1. Select a 3cm×3cm quartz glass sheet as the substrate, and wash with a mixed solution of concentrated sulfuric acid and hydrogen peroxide at 60° C. for 10 minutes.

[0060] S2. Disperse the functionalized colloidal core-shell quantum dots CdSe-ZnS in a toluene solvent at a concentration of 30 mg / mL. The FCV solution with a mass fraction of 1% is prepared, and then the quantum dot solution and the FCV solution are mixed in a volume ratio of 1:1 to complete the preparation of the polymer-doped quantum dot gain medium mixed solution. The polymer-doped quan...

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Abstract

The invention discloses a biosensor and a preparation method thereof. The biosensor comprises a substrate and a ring-core cavity formed by curing on the substrate. The material of the ring-core cavity is a gain medium material capable of adsorbing biomolecules. The optical refractive index of the substrate is smaller than the refractive index of the ring core cavity. The biosensor preparation method includes the following steps: using an inkjet printing process to drip a gain medium solvent on the surface of a substrate; after the solvent is volatilized, self-assemble to form a solid ring-core cavity to complete a biosensor based on the on-chip ring-core cavity make. The present invention utilizes simple inkjet printing technology, combined with low-cost doping process, and can realize low-cost, large-area, arrayed, high-yield, miniaturized, and integratable on-chip biosensor fabrication.

Description

technical field [0001] The invention belongs to the technical field of solution refractive index measurement, in particular to a biosensor based on a self-assembled quantum dot ring core cavity and a preparation method thereof. Background technique [0002] The basic principle of biosensors is to use biological targets as identifiers to convert biochemical reactions into quantitative physical or chemical signals, thereby realizing the detection and monitoring of life and chemical substances. Biosensor is an interdisciplinary subject that organically combines biological active materials with physical and chemical transducers. Biosensors involve not only modern biotechnology, microelectronics, but also optics, chemistry and other research fields. At present, the field of biosensors is growing rapidly all over the world, and there is a vast space for development in disease diagnosis, anti-cancer drug development, bioengineering, drug analysis, food hygiene inspection and envir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/58G01N21/41G01N21/64
CPCG01N21/41G01N21/6428G01N33/582G01N2021/6439
Inventor 徐小春万磊马文平
Owner BEIFANG UNIV OF NATITIES