A kind of microneedle capable of extracting skin tissue fluid and its preparation method

An interstitial fluid and microneedle technology, which can be used in inoculation and ovulation diagnosis, medical science, surgery, etc., can solve the problems of complicated microneedle preparation process, high preparation cost, and brittle preparation materials, so as to achieve no risk of fracture, no additional devices, and rapid Extracted effects
CN110664439BActive Publication Date: 2021-07-27HUAZHONG UNIV OF SCI & TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2021-07-27

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Abstract

The invention discloses a microneedle capable of extracting skin tissue fluid and a preparation method thereof. The microneedle comprises a porous network framework interpenetrated and a hydrophilic polymer layer modified on the inner and outer surfaces of the framework. The preparation method is specifically to prepare a mixed solution of polymer and porogen first, then fill them into the microneedle mold, and then remove the porogen therein to obtain a porous network skeleton with interpenetration, and finally in the porous network skeleton The inner and outer surfaces are modified with a hydrophilic polymer layer. The present invention obtains the microneedle capable of extracting skin tissue fluid by improving the thickness of the hydrophilic polymer layer used in the microneedle, the porosity and aperture of the microneedle, and the overall process design of the corresponding preparation method. The microneedles provided by the invention have good biocompatibility, fast extraction of skin tissue fluid, no external negative pressure device, no obvious pain and skin infection, and no need for professional operation.
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Description

technical field

[0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a microneedle capable of extracting skin tissue fluid and a preparation method thereof, which can be used for extracting skin tissue fluid. Background technique

[0002] Timely diagnosis plays an important role in disease treatment and monitoring of physical status. Extracting body fluid samples is the first and critical step for timely diagnosis. Blood is often used for timely diagnosis due to its rich metabolite content. However, taking blood requires pricking the skin and penetrating the nerve cell-rich dermis, which can cause pain and skin irritation.

[0003] The composition of skin tissue fluid is similar to that of blood, and the composition of skin tissue fluid changes with the composition of plasma. Therefore, skin tissue fluid can replace blood for sample extraction. Generally, skin tissue fluid can be extracted by pipette technology and mi...

Claims

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