Transdermal gel patch for promoting drugs with low skin absorption ability and preparation method of transdermal gel patch

A technology of transdermal gel patch and absorption capacity, applied in the field of medicine, can solve the problems of many components, complicated preparation method, etc., and achieve the effects of improving the penetration amount, simple preparation method and few auxiliary materials.

Pending Publication Date: 2020-02-14
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this patent, there are many ingredients for preparing cataplasm, and the preparation method is complicated. The prepared transdermal patch needs to be specially added with a transdermal penetration enhancer to achieve the desired effect.

Method used

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  • Transdermal gel patch for promoting drugs with low skin absorption ability and preparation method of transdermal gel patch
  • Transdermal gel patch for promoting drugs with low skin absorption ability and preparation method of transdermal gel patch
  • Transdermal gel patch for promoting drugs with low skin absorption ability and preparation method of transdermal gel patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1, the preparation of a kind of tanshinone IIA nano drug crystal

[0075] Weigh 0.05g of sodium lauryl sulfate and 0.08g of hydroxypropyl methylcellulose E5, add them into 30mL of distilled water to make them fully dissolve and swell, add 0.3g of tanshinone ⅡA raw material under magnetic stirring, and stir for 20 minutes to obtain coarse suspension. This coarse suspension is then transferred to a nanomill for grinding. Grinding conditions are: the particle size of yttrium-stabilized zirconia grinding beads is 0.6-0.8mm, the rotation speed of the stirring shaft is 2000rpm, and the particle size and potential are sampled after 45 minutes. figure 1 A and 1B.

[0076] Take a fresh sample of the prepared tanshinone IIA nanosuspension, add mannitol as a lyoprotectant at a concentration of 1% m / v, then pre-freeze at -70°C for 24 hours, and then transfer to a freeze dryer for lyophilization , to obtain freeze-dried nanocrystals. Among them, the scanning electron ...

Embodiment 2

[0077] Example 2, Preparation of Tanshinone IIA Mesoporous Silica Dispersion

[0078] Weigh 0.5g of Tanshinone IIA, dissolve it in 35ml of chloroform, make it fully dissolved, add 1g of Syloid244FP (pore size 20nm) mesoporous silica under magnetic stirring, ultrasonically disperse for 20-40min, then magnetically stir for 24 hours, take the precipitate Place in a vacuum drying oven and dry to constant weight to obtain a mesoporous silica dispersion whose surface morphology is as follows: figure 1 As shown in E, it can be seen that the tanshinone IIA silica dispersion maintains its amorphous state.

Embodiment 3

[0079] Embodiment 3, the preparation of tanshinone IIA gel patch

[0080] Prepared by the following steps:

[0081] (1) Disperse 56% sodium polyacrylate X30, 0.1% aluminum glycolate, 0.05% aluminum hydroxide, and 0.1% methylparaben in 30% glycerin under stirring conditions to form phase A.

[0082] (2) Disperse 0.15% tartaric acid, 2% polyvinyl alcohol, and 902% polyvinylpyrrolidone K in water under agitation to form phase B.

[0083] (3) Disperse the tanshinone IIA powder and the nanocrystal or mesoporous silica dispersion with the same drug loading in the phase A under the condition of stirring to form the phase C.

[0084] (4) Add phase B to phase C, mechanically stir until it can be coated, and then use a glass rod to evenly coat the non-woven fabric (7×10cm) with a thickness of 1mm. After coating, leave it at room temperature for 24 hours Put the anti-adhesive film on the back cover, and you have it.

[0085] In the gel patch with tanshinone Ⅱ A as the model drug, the ...

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Abstract

The present invention relates to the technical field of medicines and particularly to a transdermal gel patch for promoting drugs with low skin absorption ability and a preparation method of the transdermal gel patch. The transdermal gel patch comprises (1) an outward-facing backing layer; (2) a gel layer applied on the backing layer; and (3) a removable anti-adhesion layer; and the gel layer contains nano-drugs or drug-loaded mesoporous silica dispersion drugs. Nano drug crystals reduce drug particle size to a nanometer level, surface area is increased, while the drug-loaded mesoporous silicadispersion mainly increases concentration difference between a preparation and a skin layer by amorphously transforming the drugs to increase infiltration capacity, and higher drug utilization rate for transdermal drug administration can be realized. The prepared gel patch is free of skin irritation, has a function of softening stratum corneum, has suitable peeling strength and rheological properties, further promotes transdermal absorption of the drugs, provides new ideas for development of traditional drugs and provides a reference for an application of a modern preparation technology in atransdermal drug administration system.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a gel patch for promoting transdermal absorption of drugs with low skin absorption capacity, a preparation method and application thereof. Background technique [0002] Transdermal drug delivery systems (TDDS) have developed rapidly in the past few decades, and the application of this technology enhances patient compliance, prolongs drug effective time, improves tissue targeting, and avoids the first-pass effect in the liver Wait. In recent years, gel patches have been increasingly used in TDDS. Compared with traditional pressure-sensitive adhesive patches, ointments and gels, the cross-linked hydrogel polymer layer of the gel patch has high drug loading, good compatibility with water-soluble and fat-soluble drugs, and good skin The advantages of conformability and non-contamination of clothing. In particular, their high moisture content helps to soften the stratum corneum, i...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/69A61K31/58
CPCA61K9/7023A61K47/6923A61K31/58
Inventor 杨建宏顾相帅牛阳余建强赵启鹏马英峰
Owner NINGXIA MEDICAL UNIV
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