Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ferroferric oxide/bismuth sulfide nanocomposite, preparation and application thereof

A nano-composite material, ferric oxide technology, applied in wave energy or particle radiation treatment materials, drug combination, X-ray contrast agent preparation, etc., can solve the lack of image information, poor cell compatibility and utilization efficiency of photothermal materials Low-level problems, achieving excellent photothermal conversion efficiency, easy preparation, and good biocompatibility

Active Publication Date: 2020-06-05
UNIV OF SHANGHAI FOR SCI & TECH
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: the existing photothermal materials lack image information inside the tumor, have poor cell compatibility and low utilization efficiency

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ferroferric oxide/bismuth sulfide nanocomposite, preparation and application thereof
  • Ferroferric oxide/bismuth sulfide nanocomposite, preparation and application thereof
  • Ferroferric oxide/bismuth sulfide nanocomposite, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] 0.32g anhydrous FeCl 3 and 0.3g PSSMA were dissolved in 20mL diethylene glycol, stirred at 60°C for 30min, then 0.5g CH 3 COONa was added to the mixture. After dissolving for 30min, transfer to a 100mL stainless steel reaction kettle lined with p-polyphenylene and seal it. Put the reaction kettle into a high-temperature oven for heat treatment at 200°C for 7 hours, and after cooling to room temperature naturally, centrifuge the reaction mixture (8500rpm, 5min), wash with distilled water and ethanol three times each, and obtain the product Fe 3 o 4 particles. Finally the samples were vacuum dried for further use.

[0056] Dissolve 0.2 g of dopamine in 40 mL of Tris-HCl buffer solution (pH=8.5), then add 80 mg of Fe 3 o 4 particles. Completely disperse under the condition of ultrasound, place on the shaker to react for 4h, centrifuge the reaction mixture (8500rpm, 5min), wash the product with water and ethanol three times respectively. The final product obtained i...

Embodiment 2

[0060] Get the Fe prepared in a little embodiment 1 3 o 4 @PDA @BSA-Bi 2 S 3 Particles, dispersed in distilled water, in PBS, in 1640 medium, Figure 1a -c shows that the hydration kinetic diameter of the material has no obvious change after being placed for 5 days, and the Tyndall phenomenon is obvious in the three systems, all of which have good colloidal stability. The morphology and microstructure of the materials were observed by TEM. After an appropriate amount of nanosheets were dispersed uniformly in absolute ethanol by ultrasonic, the copper grid coated with carbon film was immersed in the above absolute ethanol. After the sample was naturally dried, it was observed and photographed by TEM (the operating voltage of the TEM was 200kV). Depend on Figure 2a , 2b It can be seen that the material structure obtained in Example 1 is ultra-small nanoparticles.

Embodiment 3

[0062] Use TGA (TGA-50 thermal gravimetric analyzer) to test and calculate the Fe prepared in Example 1 3 o 4 @PDA @BSA-Bi 2 S 3 The percentage content of each component in the particle, respectively take a certain mass of Fe 3 o 4 , Fe 3 o 4 @PDA, BSA-Bi 2 S, Fe 3 o 4 @PDA @BSA-Bi 2 S 3 The particles were added to the platinum crucible of the thermogravimetric analyzer, and the experimental parameters were set after reading the mass of the added sample for TGA test. The test condition was to increase from room temperature to 800°C at 15°C / min in an air atmosphere. Use FTIR (NicoletNexus 670 infrared spectrometer) to test and analyze the Fe prepared in Example 1 3 o 4 @PDA @BSA-Bi 2 S 3 Composition and structure, take a little Fe 3 o 4 @PDA, BSA-Bi 2 S 3 , Fe 3 o 4 @PDA @BSA-Bi 2 S 3 The particles are mixed with a certain amount of potassium bromide (KBr) powder respectively, and ground under an infrared lamp to ensure that the sample is dry. After being ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a ferroferric oxide / bismuth sulfide nanocomposite and a preparation method and application thereof. The preparation method comprises the following steps: dispersing Fe3O4 and dopamine into a Tris-HCl buffer solution to obtain Fe3O4@PDA nanoparticles; dispersing a bismuth source in a solvent, and then dropwise adding the bismuth source into a bovine serum albumin solution toobtain BSA-Bi2S3 particles; dispersing the Fe3O4@PDA nanoparticles into a Na2HPO4-NaH2PO4 buffer solution, adding the BSA-Bi2S3 particles to obtain Fe3O4@PDA@BSA-Bi2S3 nanoparticles. The nanocomposite obtained by the invention is easy to prepare and non-toxic, and has good biocompatibility, colloid stability and MRI & CT contrast effect at cellular and animal levels.

Description

technical field [0001] The invention relates to a contrastable iron ferric oxide bismuth sulfide nanocomposite material and its preparation and application, belonging to the technical field of bionano materials. Background technique [0002] Cancer (malignant tumor) is a large class of diseases characterized by abnormal cell proliferation and metastasis, and has become a major threat to human health and survival. The current clinical methods of cancer treatment: surgical resection, chemotherapy and physical radiation therapy. Its main feature is that surgical treatment cannot completely remove all cancer cells in the human body under normal circumstances, and it is easy to relapse; chemotherapy uses drugs to kill cancer cells, but drug resistance is easy to develop during the treatment process; Great harm and side effects. Therefore, for early screening and diagnosis of cancer, it is helpful to formulate a reasonable treatment plan and timely inhibit the proliferation and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/26A61K47/69A61K49/04A61K49/12A61K49/18A61P35/00
CPCA61K41/0052A61K33/26A61K47/6935A61K47/6929A61K49/04A61K49/126A61K49/1869A61K49/183A61P35/00A61K49/0002A61K2300/00
Inventor 王世革罗科义
Owner UNIV OF SHANGHAI FOR SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com