Long-term anti-freezing antibacterial coating for extracorporeal membrane oxygenation (ECMO) device and preparation method of long-term anti-freezing antibacterial coating

An antibacterial coating and oxygenation technology, which is applied in the field of new biomedical materials and devices, can solve the problems that the antifouling coating is not suitable for medical devices and hinder the adhesion of bacteria, so as to retain the anticoagulation function, reduce the risk of bacterial infection, good anticoagulant effect

Active Publication Date: 2020-06-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the coating cannot be perfect, once the bacteria attach to the antifouling surface, the bacteria grow and multiply from one point to a large area, and finally form a biofilm, which shows that the pure antifo

Method used

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  • Long-term anti-freezing antibacterial coating for extracorporeal membrane oxygenation (ECMO) device and preparation method of long-term anti-freezing antibacterial coating
  • Long-term anti-freezing antibacterial coating for extracorporeal membrane oxygenation (ECMO) device and preparation method of long-term anti-freezing antibacterial coating
  • Long-term anti-freezing antibacterial coating for extracorporeal membrane oxygenation (ECMO) device and preparation method of long-term anti-freezing antibacterial coating

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Effect test

Embodiment 1

[0032] A preparation method for a long-acting anticoagulant antibacterial coating for an extracorporeal membrane oxygenation device (ECMO), comprising the following steps:

[0033] (1) Preparation of antibacterial functional monomers

[0034] In the reaction flask, add 1 mass part of monomer dimethylaminoethyl methacrylate (DMAEMA), then add 1.3 mass parts of n-octane bromide, then add 4 mass parts of acetonitrile, 0.01 mass parts of sodium iodide , reflux at 60°C for one week. Then the reaction solution was concentrated, and ether was added for precipitation, and the precipitation was repeated three times to obtain a methacrylic acid monomer with a quaternary ammonium salt in the side chain.

[0035] (2) Preparation of anticoagulant antibacterial polymer

[0036] Add 0.23 parts by mass of methacryloyloxyethyl phosphorylcholine, 0.42 parts by mass of lauryl methacrylate, 0.05 parts by mass of antibacterial functional monomer, and 0.25 parts by mass of hydroxyisopropyl methac...

Embodiment 2

[0039] A preparation method for a long-acting anticoagulant antibacterial coating for an extracorporeal membrane oxygenation device (ECMO), comprising the following steps:

[0040] (1) Preparation of antibacterial functional monomers

[0041] In the reaction flask, add 1 mass part of monomer dimethylaminoethyl methacrylate (DMAEMA), then add 1.3 mass parts of n-octane bromide, then add 4 mass parts of acetonitrile, 0.01 mass parts of sodium iodide , reflux at 60°C for one week. Then the reaction solution was concentrated, and ether was added for precipitation, and the precipitation was repeated three times to obtain a methacrylic acid monomer with a quaternary ammonium salt in the side chain.

[0042] (2) Preparation of anticoagulant antibacterial polymer

[0043] Add 0.28 parts by mass of methacryloyl ethyl sulfobetaine, 0.52 parts by mass of lauryl methacrylate, 0.1 parts by mass of antibacterial functional monomer, and 0.1 parts by mass of isocyanate ethyl methacrylate ,...

Embodiment 3

[0046] A preparation method for a long-acting anticoagulant antibacterial coating for an extracorporeal membrane oxygenation device (ECMO), comprising the following steps:

[0047] (1) Preparation of antibacterial functional monomers

[0048] In the reaction bottle, add 1 mass part of monomer dimethylaminoethyl methacrylate (DMAEMA), then add 1.3 mass parts of n-bromobutane, then add 4 mass parts of acetonitrile, 0.01 mass parts of sodium iodide , reflux at 60°C for one week. Then the reaction solution was concentrated, and ether was added for precipitation, and the precipitation was repeated three times to obtain a methacrylic acid monomer with a quaternary ammonium salt in the side chain.

[0049] (2) Preparation of anticoagulant antibacterial polymer

[0050] Add 0.2 parts by mass of methacryloyloxyethyl phosphorylcholine, 0.4 parts by mass of lauryl methacrylate, 0.1 parts by mass of antibacterial functional monomer, and 0.25 parts by mass of hydroxyisopropyl methacrylate ...

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Abstract

The invention discloses a long-term anti-freezing antibacterial coating for extracorporeal membrane oxygenation (ECMO) device and a preparation method of the long-term anti-freezing antibacterial coating. The method comprises the following steps: (1) mixing an anti-freezing functional monomer, an antibacterial functional monomer and a film formation agent, and performing a reaction in a mode of free radical polymerization for 10-15 hours at 60-80 DEG C so as to obtain an anti-freezing antibacterial polymer; and (2) mixing the anti-freezing antibacterial polymer with a solvent, so as to obtainthe long-term anti-freezing antibacterial coating. The invention designs the coating with long-term anti-freezing and antibacterial functions simultaneously, and antifouling and sterilization functions can be well combined. With the combination of two functions, an effect of reducing risks of bacterium infection for a long time can be achieved. By reasonably selecting and controlling introductionof antibacterial functional components, the anti-freezing function of the coating can be well maintained.

Description

technical field [0001] The invention belongs to the technical field of biomedical new materials and devices, and in particular relates to a long-acting anticoagulant antibacterial coating for an extracorporeal membrane oxygenation device (ECMO) and a preparation method thereof. Background technique [0002] For medical devices that need long-term contact with blood, preventing the formation of thrombus and bacterial infection is a very key technical challenge. Although the use of drugs such as heparin and antibiotics can reduce certain risks, they still cannot meet the clinical needs. The reasons are as follows . [0003] On the one hand, in blood-contact devices, once blood touches the device surface, platelets and fibrinogen adhere to the surface of the material, and after activation, blood cells will be fixed by fibrin cross-linking to form a thrombus. Blood clots block blood vessels and can cause serious illness or even death. On the other hand, bacteria adhere to the ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/14A61L31/16
CPCA61L31/10A61L31/14A61L31/16A61L2300/404A61L2300/42A61L2300/606A61L2420/02A61L2420/06C08L43/04C08L33/14C08L35/00
Inventor 王云兵张凡军罗日方杨立王京玉武迪蒙
Owner SICHUAN UNIV
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