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Cuprous sulfide nano material for electrochemical sensor and preparation method thereof

A technology of cuprous sulfide and nanomaterials, which is applied in the field of nanomaterials and electrochemical sensing, can solve the problems of electrochemical sensors without cuprous sulfide nanomaterials, and achieve the effects of fast detection speed, convenient operation and low detection limit

Pending Publication Date: 2020-06-23
SHANGHAI UNIV OF MEDICINE & HEALTH SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no electrochemical sensor based on cuprous sulfide nanomaterials, which can be applied to the determination of paracetamol

Method used

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  • Cuprous sulfide nano material for electrochemical sensor and preparation method thereof
  • Cuprous sulfide nano material for electrochemical sensor and preparation method thereof
  • Cuprous sulfide nano material for electrochemical sensor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Synthesis of Cuprous Sulfide Nanomaterials

[0034] Mix 2.50 mmol of ammonium diethyldithiocarbamate with 20 mL of dodecanethiol and 34 mL of oleic acid in a three-necked flask. solution in nitrogen (N 2 ) was heated to 110 ° C under flowing, and then a suspension composed of 2 mmol copper acetylacetonate and 3 mL oleic acid was injected rapidly. Then, the solution is rapidly heated to 180° C., and kept at this temperature for 10-30 minutes (it is necessary to ensure that the airtightness of the device is good before all reactions, and pass N 2 The apparatus was vented of air and all solutions used were anhydrous to avoid any possible oxidation). After the reaction, there will be Cu 2-x The solution of S nanocrystals was naturally cooled to 120° C., then taken out from the flask, and centrifuged at 20,000 rpm for 10 minutes. Discard the supernatant, dissolve the pellet in 18.4 mL of toluene and 56 mL of isopropanol, and then centrifuge at 20,000 rpm for 10 minutes. ...

Embodiment 2

[0036] Cuprous sulfide modified electrode (Cu 2-x S-GC) preparation

[0037] First, the bare glassy carbon electrode (GC) was polished to a mirror surface with alumina powder (0.1 μm) and alumina powder (0.05 μm) on the suede in turn, rinsed with deionized water twice, rinsed with ethanol and ultrasonically washed for 1 min. Dry and cool for later use. A certain amount of synthesized Cu 2-x Material S (2 mg) was mixed with 50 μL chitosan (1 mg / mL) and 80 μL chloroform, and then 4.0 μL of the mixed solution was dropped on the surface of the treated optical glassy carbon electrode. After drying, the modified electrode was thoroughly rinsed with double distilled water. When not in use, the modified electrode was polished to a mirror surface with aluminum oxide powder on the suede, and then immersed in a phosphate buffer solution (pH7.0, 0.1mol L -1 ), stored at a constant temperature of 4°C.

Embodiment 3

[0039]X-ray Diffraction (XRD) Spectrum Test

[0040] Cu 2-x S nanomaterials were synthesized by thermally injecting acetylacetone and ammonium diethyldithiocarbamate solutions in a mixed solution of dodecanethiol and oleic acid, and Cu with different particle sizes were prepared by controlling different reaction times 2-x S nanoparticles. In order to determine and analyze the phase of nanomaterials, X-ray diffraction (XRD) was used for characterization ( figure 1 ). The test results show that the material prepared by thermal injection is hexagonal chalcocite Cu 1.96 S (JCPDS15-157), the angles, peak heights, and peak shapes of the two peaks are basically the same, and the characteristic diffraction peaks (37.7°, 46.2°, 46.6°, 48.6°) basically overlap. Further comparison of Cu prepared at different synthesis times (10min, 20min and 30min) 2-x The half-width of the diffraction peak of S is stronger. It can be seen that the longer the reaction time, the smaller the half-widt...

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Abstract

The invention discloses a cuprous sulfide nano material for an electrochemical sensor and a preparation method of the cuprous sulfide nano material. According to the experiment, cuprous sulfide nanoparticles with different sizes are synthesized by adopting a thermal injection method, the phase structure of the material is determined by X-ray diffraction (XRD), and a transmission electron microscope (TEM) represents the apparent morphology of the material. A cuprous sulfide nanoparticle modified working electrode is prepared through a dispensing method, and the electrocatalytic behavior of different materials on acetaminophen is investigated by using cyclic voltammetry (CV) and linear voltammetry (LSV). According to the preparation method, cuprous sulfide nano materials with different diameters are synthesized by adopting an organic phase, and Cu2-xS nano particles with the best electrochemical response and the smallest particle size are selected to successfully perform glassy carbon electrode modification and be used for realizing electrochemical detection of trace acetaminophen. The electrochemical analysis method is used for measuring and characterizing the electrochemical properties of the drug, and has the advantages of low detection limit, high sensitivity, high detection speed, low price and the like.

Description

technical field [0001] The invention relates to the technical field of nanomaterials and electrochemical sensing, in particular to a cuprous sulfide nanomaterial for electrochemical sensors and a preparation method thereof. Background technique [0002] Acetaminophen, English name acetaminophen (ACOP), also known as paracetamol, is a very effective and very safe antipyretic and analgesic drug, which can effectively relieve headache, fever, toothache, rheumatic pain, joint pain, nerve pain, etc. About 80% of cold medicines for the treatment of pain and other symptoms contain acetaminophen; taking a normal dose of paracetamol (300mg / L) has little irritation to the gastrointestinal tract and has little effect on the body; Toxic and side effects such as dizziness, vomiting, anorexia, abdominal pain, etc., will cause hepatotoxicity after taking 10-15g (150-250mg / kg) of acetaminophen once for adults, leading to damage to liver and kidney function; when taking 20-25g or more At hi...

Claims

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Application Information

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IPC IPC(8): C01G3/12B82Y15/00B82Y30/00B82Y40/00G01N23/04G01N23/20G01N23/2251G01N27/48
CPCC01G3/12B82Y15/00B82Y30/00B82Y40/00G01N27/48G01N23/20G01N23/04G01N23/2251C01P2002/72C01P2004/04C01P2004/64
Inventor 梁莹张志远徐一新单纯玉王小芬
Owner SHANGHAI UNIV OF MEDICINE & HEALTH SCI
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