Chalcocite flotation agents are made of the following raw materials including, by weight, 15-18 parts of black powder, 20-24 parts of m-benzenedicarbonyl thiourea, 8-10 parts of drainage oil, 5-7 parts of ethyl alcohol, 2-4 parts of butyl acrylate, 5-7 parts of AEO, 2-4 parts of polyacrylamide, 1-2 parts of chitosan, 0.6-1.4 parts of nanometer titanium dioxide, 1-2 parts of sodium hydroxide, 1-2 parts of sodium hydrogen phosphate, 1-2 parts of boronic acid and 4-5 parts of activating agents. As the nanometer titanium dioxide is added, the chalcocite flotation agents are uniform and stable in dispersion, have stable foam and are good in flocculation effect, good in copper collecting performance, high in copper yield, good in selectivity, good in rejection capability and high in copper grade. The activating agents are stable in dispersion, good in permeability, good in activating performance, long in duration time of the flocculation effect and capable of improving the yield and grade of copper.