The invention discloses a production technology for lead and zinc floatation mineral powder. The technology sequentially comprises the steps of a, ore crushing, b, ore grinding, c, ore dissolving pulp preparing, d, dosing and stirring, e, lead floatation, f, zinc floatation, g, water removing and h, milltailing treatment. Added drugs comprise inhibitors, collecting agents, activating agents and foaming agents. The inhibitors are made of one or several of zinc sulfate, lime, sodium sulphide and sodium sulfite, so that the hydrophilic property of the zinc ore is enhanced, and upward floating of the zinc ore is inhibited; the problem that the grade of zinc in the lead concentrates is high is solved, and the zinc recycling rate is improved; meanwhile, used flotation reagents are small in consumption, and the cost is saved; the whole production technology is environment-friendly; and the production technology is good in floatation effect, non-poisonous, free of time bound, wide in raw material resource and capable of being widely applied and popularized.