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Preparation method and application of polypropylene oxide-sodium alginate hydrogel

A technology of polypropylene oxide and sodium alginate, applied in the field of medicine, can solve the problems of short duration of effective concentration, inability to meet clinical treatment, etc., and achieves the improvement of action time and treatment effect, high drug loading efficiency, and improved treatment effect. Effect

Inactive Publication Date: 2020-06-26
广州古泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually traditional dosage forms, such as injections, tablets, capsules, etc., have been unable to meet the needs of clinical treatment due to the short duration of effective concentration.

Method used

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  • Preparation method and application of polypropylene oxide-sodium alginate hydrogel
  • Preparation method and application of polypropylene oxide-sodium alginate hydrogel
  • Preparation method and application of polypropylene oxide-sodium alginate hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The synthetic method of polypropylene oxide-sodium alginate hydrogel:

[0022] Formula (III) (8.41 g, 40 mmol), formula (II) (1.93 g, 5 mmol) and 4-dimethylaminopyridine (0.0386 g, 0.316 mmol) were weighed and dissolved in 20 mL of anhydrous tetrahydrofuran. Then, dicyclohexylcarbodiimide (3.09 g, 15 mmol) was added into anhydrous tetrahydrofuran (5 mL), and dropped into an ice bath. The resulting mixture was stirred at 30 °C for 12 h, the reactant was filtered, the solvent was removed by rotary evaporation, and the product was purified by recrystallization from ethyl acetate to obtain the product formula (IV);

[0023] Weigh 2g formula (Ⅳ) (3.5mmol) and 1.32g EDC (6.9mmol) and dissolve in 20mL absolute ethanol, stir and react for 50 minutes to activate the carboxyl group; formula (Ⅴ) (3.5mmol) and 0.079g NHS (0.687mmol) Dissolve in 20mL of deionized water to activate the hydroxyl group, and slowly add the activated formula (Ⅴ) (3.5mmol) into the aqueous solution of th...

Embodiment 2

[0025] Preparation of Nedaplatin-loaded polypropylene oxide-sodium alginate hydrogel

[0026] Nedaplatin was encapsulated into the crosslinked network of polypropylene oxide-sodium alginate hydrogel. 50mg of polypropylene oxide-sodium alginate hydrogel, 10mg of nedaplatin were dissolved in the dimethyl sulfoxide / water system with a volume ratio of 1:9, and after desalting at room temperature for 24 hours, it was slowly added dropwise into a large amount of ultrapure water (500 mL), and then stirred rapidly at room temperature for 1 hour. The solution was dialyzed against ultrapure water and filtered through a 0.45 μm needle filter to obtain nedaplatin-loaded hydrogel.

Embodiment 3

[0028] Drug loading capacity (DLC) and drug loading efficiency (DLE) of nedaplatin-loaded polypropylene oxide-sodium alginate hydrogel

[0029] Morphology: A drop of hydrogel solution was evenly dropped on the copper grid with carbon film, and then after it was dried at room temperature, TEM was used to capture the topography picture of the micelles. Particle size: The average size and size distribution of the micelles were determined by DLS. figure 1 The topography images of chitosan-sodium alginate hydrogels loaded with nedaplatin were captured by TEM, figure 2 Size distribution profile of nedaplatin-loaded polypropylene oxide-sodium alginate hydrogels determined by DLS.

[0030] Drug Loading Capacity (DLC) and Drug Loading Efficiency (DLE): Freeze Nedaplatin-loaded polypropylene oxide-sodium alginate hydrogel to obtain a blue solid powder, dissolve the powder in methanol, and repeat the preparation of 4 batches Nedaplatin-loaded polypropylene oxide-sodium alginate hydrog...

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Abstract

The invention provides a preparation method and an application of a polypropylene oxide-sodium alginate hydrogel. The polypropylene oxide-sodium alginate hydrogel provided by the invention is used asa drug carrier, and has the characteristics of simple synthesis method, high encapsulation efficiency and the like; and the carrier hydrogel has a group having high affinity for a living body, is lowin biotoxicity, is an oral hydrogel carrier, can protect medicines in the hydrogel carrier from being released under the acidic condition of the stomach, enables the medicines to target intestinal tumors rich in glutathione, can slowly release and transfer the medicines to improve the treatment effect, and is expected to have wide substantive application as a new medicine carrying carrier hydrogel.

Description

technical field [0001] The invention relates to the preparation and application of a polypropylene oxide-sodium alginate hydrogel, which belongs to the field of medicine. Background technique [0002] Drug delivery systems refer to pharmaceutical preparations that improve the therapeutic effect of drugs through different administration forms. Usually traditional dosage forms, such as injections, tablets, capsules, etc., have been unable to meet the needs of clinical treatment due to the shortcoming of their effective concentration maintenance time. In order to overcome this defect, new drug delivery systems such as hydrogel drug loading have attracted extensive attention of researchers. [0003] The molecular weight of the degraded product of the hydrogel polymer carrier is lower than the excretion limit of the kidney (<30kDa), and the safety is improved. Among them, sodium alginate is particularly noteworthy in its bio-affinity and bio-absorbability. When it is implant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/04C08J3/075C08L5/04A61K9/06A61K45/00A61K47/36A61P35/00A61P35/02
CPCA61K9/06A61K45/00A61K47/36A61P35/00A61P35/02C08B37/0084C08J3/075C08J2305/04
Inventor 貌惠玲
Owner 广州古泉生物科技有限公司
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