Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of polydopamine film and application of polydopamine film in medical implant material

A technology of polydopamine film and implant material, which is applied in medical science, devices for coating liquid on the surface, coating, etc., and can solve problems such as depolymerization and film dissolution, loading problems, and corrosion

Active Publication Date: 2020-07-07
B J ZH F PANTHER MEDICAL EQUIP
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ammonia solution of sulfadiazine silver is corrosive to the polydopamine film, especially ammonia water can cause the depolymerization and film dissolution of the polydopamine film; further, the catalyst trifluoromethanesulfonic acid or trifluoromethanesulfonate will There is a certain amount of attachment and binding on the polydopamine film, and it competes with silver sulfadiazine for the attachment site, and trifluoromethanesulfonic acid or trifluoromethanesulfonate also has certain toxicity, so it is not suitable for the field of medical devices; the above Reasons that make the loading of silver sulfadiazine on the surface of biomedical implant materials a problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of polydopamine film and application of polydopamine film in medical implant material
  • Preparation method of polydopamine film and application of polydopamine film in medical implant material
  • Preparation method of polydopamine film and application of polydopamine film in medical implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] 1. Preparation of polydopamine coating:

[0058] 1.1 The cleaned pure titanium medical implant material is irradiated with ultraviolet rays for 1 hour, then soaked in Tris-HCL solution containing 2g / L dopamine monomer at pH 8.5, and then calcium peroxide with a final concentration of 10mg / L is added. Immediately put the reaction bottle containing the mixture into the body cavity of a temperature-controllable focusing microwave synthesizer, react at a constant temperature of 25°C for 3 minutes, and microwave power at 300W, and a dense polydopamine film can be obtained on the surface of the implant , take out and repeatedly ultrasonically wash and rinse with deionized water, and dry with nitrogen.

[0059] 1.2 does not repeat 1.1. The polydopamine film is a single layer.

[0060] 2. In Situ Synthesis of Silver Sulfadiazine on Conventional Polydopamine Films

[0061] 2.1 Put the material treated in 1.2 in a solution of sulfadiazine (20mmol / L) in sodium hydroxide (20mmol...

Embodiment 2

[0064] 1. Preparation of polydopamine coating:

[0065] 1.1 Irradiate the cleaned titanium alloy (TI-6AL-4V) medical implant material under ultraviolet light for 6 hours, then soak it in a pH7.1 Tri-HCL solution containing 1g / L dopamine monomer, and then add a final concentration of 20mg / L of calcium peroxide, immediately put the reaction bottle containing the mixture into the body cavity of the temperature-controllable focusing microwave synthesizer, react at a constant temperature of 65°C for 5 minutes, and the microwave power is 100W, and a A dense polydopamine film was taken out, washed repeatedly by ultrasonic waves, rinsed with deionized water, and dried with nitrogen.

[0066] 1.2 Repeat step 1.1 4 times. The final polydopamine film is 5 layers.

[0067] 2. In Situ Synthesis of Silver Sulfadiazine on Conventional Polydopamine Films

[0068] 2.1 Place the material treated in 1.2 in a solution of sulfadiazine (30mmol / L) in sodium hydroxide (45mmol / L), pH 8.7, so that ...

Embodiment 3

[0071] 1. Preparation of polydopamine coating:

[0072] 1.1 The cleaned titanium alloy (Ti-25nb-10ta-1zr-0.2fe) medical implant material was irradiated under ultraviolet light for 12 hours, and then soaked in a pH8.0 Tri-HCL solution containing 3g / L dopamine monomer, Calcium peroxide with a final concentration of 40 mg / L was then added, and the reaction bottle containing the mixture was immediately put into the body cavity of a temperature-controllable focusing microwave synthesizer, and reacted at a constant temperature of 50°C for 11 minutes, and the microwave power was 100W, and the plant was ready. A dense polydopamine film was obtained on the surface of the object, which was taken out and washed repeatedly with ultrasonic waves, rinsed with deionized water, and dried with nitrogen gas.

[0073] 1.2 Repeat step 1.1 9 times. The polydopamine film is 10 layers.

[0074] 2. In Situ Synthesis of Silver Sulfadiazine on Conventional Polydopamine Films

[0075] 2.1 Put the mater...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a polydopamine film and application of the polydopamine film in a medical implant material. According to the preparation method, in-situ synthesis of silver sulfadiazine on a conventional polydopamine film is realized through microwave irradiation. In the method, the sulfadiazine does not need to be dissolved by the traditional ammonia water, so thatthe method has the following advantages that: firstly, the corrosion effect of the ammonia water on the polydopamine film can be avoided; secondly, stimulation and corrosion of ammonia water to mucous membranes such as eyes and the nasal cavity of a worker can be avoided; and thirdly, the environmental problem caused by pungent smoke volatilized from high-concentration ammonia water can be avoided. In the method, a catalyst trifluoromethanesulfonic acid or trifluoromethanesulfonate is not used, so that the loading capacity of silver sulfadiazine can be improved, and the safety performance canbe further improved.

Description

technical field [0001] The invention relates to a preparation method of a polydopamine film and its application in medical implant materials, in particular to a preparation method of a polydopamine film in which sulfadiazine silver is synthesized in situ on a conventional polydopamine film by microwave irradiation and Its application in medical implant materials. Background technique [0002] At present, when biomedical implant materials are implanted in surgical operations, the possible infection is still a very difficult clinical problem. Although biomedical implant materials such as inorganic materials, organic materials and metals and their alloys (such as: ceramics, polymer materials, stainless steel, pure titanium and its alloys, and pure magnesium and its alloys, etc.), due to their excellent mechanical properties and Good biocompatibility has been widely used in the repair of hard and soft tissues, but these implant materials themselves do not have antibacterial and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/06C07D239/42A61L31/10A61L31/16A61L31/14C08L79/04
CPCA61L31/10A61L31/16A61L2300/104A61L2300/404C08J7/065C07D239/42A61L31/14C08J2379/04C08L79/02A61B17/11A61B2017/00893A61B2017/0647A61L2420/02B05D1/18B05D3/06C08J5/18C08J2379/02C08K5/3462
Inventor 刘青蒲丛
Owner B J ZH F PANTHER MEDICAL EQUIP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com