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Water-in-oil skin-whitening skin care lotion and preparation method thereof

A water-in-oil type skin care milk technology, which is applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of reducing the intensity of ultraviolet light and poor whitening effect, and achieve sterilization and anti-inflammation, reduce the burden, and reduce the addition of Effect

Active Publication Date: 2020-07-28
广州古泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of water-in-oil type whitening skin care emulsion and preparation method thereof, by directly adding antioxidant whitening agent in emulsion, antioxidant whitening agent contains sulfadiazine, and a large amount of amino groups contained in sulfadiazine, can Binuclear Cu with tyrosinase active center 2+ Complexation is carried out to inhibit the activity of tyrosinase and achieve the whitening effect. At the same time, the antioxidant whitening agent contains isoflavone groups, which have strong absorption in the range of 245-270nm in the ultraviolet region. There is also a certain absorption in the range of -400nm. It absorbs ultraviolet rays through isoflavone groups and reduces the intensity of ultraviolet rays directly acting on human skin. The synergistic effect of these agents can effectively achieve the whitening effect, thereby effectively solving the problem of directly adding whitening agents in order to achieve whitening effects in the preparation process of existing whitening skin care products. Whitening agents usually achieve whitening effects by inhibiting the activity of tyrosinase. However, for people who work outdoors for a long time, they are often exposed to ultraviolet rays, and the whitening effect is poor by relying on the inhibition of tyrosinase alone.

Method used

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  • Water-in-oil skin-whitening skin care lotion and preparation method thereof
  • Water-in-oil skin-whitening skin care lotion and preparation method thereof
  • Water-in-oil skin-whitening skin care lotion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The concrete preparation process of antioxidant whitening agent is as follows:

[0025] Step 1: Weigh 11g of resorcinol and add it to 200mL ethanol solution, stir and dissolve, adjust the pH of the reaction solution to 1 with hydrochloric acid, then add 2.3g of paraformaldehyde into the reaction vessel, stir and dissolve, then heat up to 70-80°C, Then add 25g of sulfadiazine to the reaction vessel, stir and dissolve, then react at a constant temperature for 4-5h, then cool down to room temperature, dropwise add a sodium hydroxide solution with a mass concentration of 1% to the product until precipitation occurs and stop adding , and then filter, wash and dry to obtain product A, and the reaction structure is as follows;

[0026]

[0027]Step 2: Add 10g of the product A prepared in step 1 into the reaction vessel, then add 4.3g of p-hydroxyphenylacetic acid, 21.6g of aluminum chloride and 150mL of ethyl acetate, heat up to 70-75°C and stir until the solid dissolves, ...

Embodiment 2

[0032] The specific preparation process of the antioxidant whitening agent is as follows: Weigh 11g of resorcinol and add it to 200mL of ethanol solution and stir to dissolve, adjust the pH of the reaction solution to 1 with hydrochloric acid, then add 4.5g of paraformaldehyde to the reaction vessel, stir to dissolve and then heat up to 70-80° C., then add 55 g of sulfadiazine to the reaction vessel, stir and dissolve, then react at a constant temperature for 4-5 hours, then cool down to room temperature, and dropwise add a sodium hydroxide solution with a mass concentration of 1% to the product until If there is precipitation, stop the dropwise addition, and then filter, wash and dry to obtain product A, which is an antioxidant whitening agent. The reaction structure is as follows;

[0033]

Embodiment 3

[0035] The concrete preparation process of antioxidant whitening agent is as follows:

[0036] Step 1: Add 10g of resorcinol to the reaction vessel, then add 8.6g of p-hydroxyphenylacetic acid, 41.6g of aluminum chloride and 250mL of ethyl acetate to it, heat up to 70-75°C and stir until the solid dissolves, then react at constant temperature 2-2.5h, then the solvent is recovered by distillation under reduced pressure, then a certain amount of hydrochloric acid solution with a mass concentration of 8% will be added to the reaction vessel, and after stirring and reacting for 30-40min, filter, wash and dry to obtain product A. The reaction structure is as follows Show;

[0037]

[0038] Step 2: 10g of the product A prepared in step 1 and 95mL N, N-dimethylformamide were added to the reaction vessel at the same time, then 42g of hexahydropyridine was added thereto, stirred and dissolved, and 21g of trihydropyridine was added dropwise to the reaction vessel. Phosphorus chlorid...

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Abstract

The invention discloses a water-in-oil skin-whitening skin care lotion. The water-in-oil skin-whitening skin care lotion comprises the following components in parts by weight of 26-29 parts of camellia oil, 18-23 parts of grape seed oil, 22-25 parts of squalane, 2-3 parts of an oxidation resisting skin whitening agent, 4-6 parts of emulsifying wax, 8-16 parts of distilled water, 11-14 parts of a hydrating agent, and 1-2 parts of a surfactant. The prepared oxidation-resisting skin whitening agent contains sulphadiazine, has certain properties of resisting bacteria and inhibiting bacteria, can effectively realize efficacy of sterilizing and diminishing inflammation of skin care products, can effectively restrain breeding of bacteria, can realize antiseptic effects, can further reduce addition of preservatives in the lotion, can effectively reduce burden to skin, and can further effectively solve the problems that in the preparation process of conventional skin care products, the preservative is directly added to the skin care products to achieve the antibacterial effect, but the added preservative can easily increase the burden to skin, and the preservative has definite stimulability, so that more crowds have intolerance to the prepared skin care lotion.

Description

technical field [0001] The invention belongs to the field of preparation of skin care emulsion, and relates to a water-in-oil type whitening skin care emulsion and a preparation method thereof. Background technique [0002] Human skin is affected by ultraviolet radiation and air pollutants, which will cause excessive free radicals and active oxygen in the body. In addition, the aging process of the body will also be accompanied by the generation of free radicals and active oxygen. At the same time, the content of the body's own antioxidant substances such as SOD is relatively reduced, which leads to a series of problems such as metabolic imbalance and decreased cell activity, and finally features such as dull skin and aging skin. At the same time, tyrosinase is also known as phenol oxidation. Enzyme, polyphenol oxidase, catechol oxidase, is a copper-containing metal oxidase with a complex structure, and tyrosinase is the key enzyme for the synthesis of melanin, although mela...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/49A61K8/31A61K8/06A61Q19/00A61Q19/02
CPCA61K8/064A61K8/31A61K8/49A61K8/92A61K8/922A61K2800/524A61K2800/72A61K2800/782A61Q19/00A61Q19/02
Inventor 不公告发明人
Owner 广州古泉生物科技有限公司
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