Blood sugar-reducing propolis-pseudo-ginseng-rehmannia pill and preparation method thereof

A rehmannia pill and hypoglycemic technology, which is applied in the direction of sugar-coated pills, pill delivery, capsule delivery, etc., can solve the problems of difficult release of active ingredients, unsuitable for long-term prevention and treatment, and unfavorable drug effects, so as to avoid nerve cell damage or Effects of death, kidney protection, and improvement of ingestion ability

Pending Publication Date: 2020-08-18
浙江金童生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In response to the problem of high blood sugar in the population, there are many hypoglycemic drugs on the market today, but most of these drugs have toxic side effects, and most patients may have some adverse reactions after taking them
The drugs used in the medical treatment of diabetes are very easy to cause side effects. If patients use these drugs for a long time, they will also cause psychological burden. They are not suitable for long-term prevention and treatment.
For example, the patent number is CN201510541624.9, a compound health product with auxiliary hypoglycemic function and its preparation method. Traditional Chinese medicines such as licorice are made through scientific processing techniques. The raw materials used are not deeply processed, which makes it difficult to release the active ingredients in the raw materials, which reduces the absorption efficiency of people. In addition, a large number of high-temperature operations are used in the production to decompose the active ingredients in the raw materials. It is beneficial to maximize the effect of drugs and affect the therapeutic effect
Another example is a composition whose patent number is CN201510216935.8, which has the effect of assisting in lowering blood sugar and blood fat. 15%, propolis 5% to 15%, Panax notoginseng saponin extract 2% to 6%; In order to solve the main factors leading to blood sugar rise, the problem of sugar metabolism in blood sugar rise was not taken into account, resulting in a single means of lowering blood sugar, prone to drug resistance, and difficult to eradicate the disease; another example is the sweet tea hypoglycemic food with patent number CN201410572624.0, It is composed of celery carrot enoki mushroom sweet tea mixed extract, cinnamon extract, cyclodextrin, xylitol, and propolis. The extract is mainly extracted with ethanol, which results in the emphasis on alcohol-soluble extracts in the drug ingredients and fails to maximize the drug. effect, and the method of lowering blood sugar is single, and the therapeutic effect is affected to a certain extent

Method used

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  • Blood sugar-reducing propolis-pseudo-ginseng-rehmannia pill and preparation method thereof
  • Blood sugar-reducing propolis-pseudo-ginseng-rehmannia pill and preparation method thereof
  • Blood sugar-reducing propolis-pseudo-ginseng-rehmannia pill and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] A hypoglycemic propolis notoginseng dihuang pill, the raw material composition and parts by weight of the active ingredients of the drug are: 68 parts of propolis alcohol extract, 65 parts of sanqi, 63 parts of rehmannia extract, 60 parts of yam, selenium-enriched 16 parts of lactic acid bacteria powder, 52 parts of angelica, 50 parts of heterophylla, 45 parts of microcrystalline fiber, 42 parts of lipoic acid polylactic acid-glycolic acid nanoparticles, 37 parts of lactose, 5 parts of cross-linked polyvinylpyrrolidone, stomach-soluble film coating 5 parts of premix;

[0020] The preparation method of the propolis alcohol extract is as follows: in parts by mass, process 20 parts of propolis into a powder with a fineness of 50 mesh, add an alcohol solution 5 times its mass to the powder, soak at 50°C for 20 minutes, and microwave 3min, stirred for 10min, filtered with 200-mesh filter cloth to obtain the filtrate filter residue; mixed the filter residue with 95% edible et...

Embodiment 2

[0029] A hypoglycemic propolis notoginseng dihuang pill, the raw material composition and parts by weight of the active ingredients of the drug are: 80 parts of propolis alcohol extract, 77 parts of Sanqi, 73 parts of rehmannia extract, 70 parts of yam, selenium-enriched 26 parts of lactic acid bacteria powder, 63 parts of angelica, 60 parts of heterophylla, 57 parts of microcrystalline fiber, 54 parts of lipoic acid polylactic acid-glycolic acid nanoparticles, 50 parts of lactose, 10 parts of cross-linked polyvinylpyrrolidone, gastric-soluble film coating 7 parts of premix.

[0030] The preparation method of the propolis alcohol extract is as follows: in parts by mass, process 30 parts of propolis into a powder with a fineness of 80 mesh, add an alcohol solution 8 times its mass to the powder, soak at 55° C. for 30 minutes, and microwave 5min, stirred for 15min, filtered with a 200-mesh filter cloth to obtain the filtrate filter residue; mixed the filter residue with 95% edib...

Embodiment 3

[0039] A hypoglycemic propolis notoginseng dihuang pill, the raw material composition and parts by weight of the active ingredients of the drug are: 77 parts of propolis alcohol extract, 69 parts of Sanqi, 67 parts of rehmannia extract, 61 parts of yam, selenium-enriched 23 parts of lactic acid bacteria powder, 57 parts of angelica, 55 parts of heterophylla, 57 parts of microcrystalline fiber, 42 parts of lipoic acid polylactic acid-glycolic acid nanoparticles, 50 parts of lactose, 5 parts of cross-linked polyvinylpyrrolidone, stomach-soluble film coating 7 parts of premix.

[0040] The preparation method of the propolis alcohol extract is as follows: in parts by mass, process 20 parts of propolis into a powder with a fineness of 80 mesh, add an alcohol solution 5 times its mass to the powder, soak at 55°C for 20 minutes, and microwave 5min, stirred for 10min, filtered with a 200 mesh filter cloth to obtain the filtrate filter residue; mixed the filter residue with 95% edible ...

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Abstract

The invention relates to the technical field of medicine preparation, in particular to a blood sugar-reducing propolis-pseudo-ginseng-rehmannia pill and a preparation method thereof. The blood sugar-reducing propolis-pseudo-ginseng-rehmannia pill is prepared from the following raw materials: propolis alcohol extract, radix notoginseng, radix rehmanniae extract, rhizoma dioscoreae, selenium-enriched lactic acid bacteria powder, radix angelicae sinensis, radix pseudostellariae, microcrystalline fiber, lipoic acid polylactic acid-glycolic acid nanoparticles, lactose, cross-linked polyvinylpyrrolidone and a gastric-soluble film coating premix. According to the invention, proliferation of glomerular mesangial cells is effectively inhibited, the activity of glomerulus is improved, and kidney function metabolism is promoted; and insulin resistance in a patient caused by accumulation of fat in skeletal muscle is reduced.

Description

technical field [0001] The invention relates to the technical field of medicine manufacture, in particular to a hypoglycemic propolis notoginseng dihuang pill and a preparation method thereof. Background technique [0002] Hyperglycemia refers to endocrine and metabolic disorders of sugar, fat, protein, electrolyte, water and other metabolic disorders and acid-base balance disorders caused by the inability of physiological hormones to meet the body's needs. At present, hyperglycemia has become the third chronic disease that seriously endangers human health after tumors and cardiovascular and cerebrovascular diseases. [0003] Aiming at the common problem of hyperglycemia in the population, there are many hypoglycemic drugs on the market today, but most of these drugs have toxic and side effects, and most patients can produce some adverse reactions after taking them. The medicines used in the medical treatment of diabetes can easily cause side effects. If patients use these ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/30A61K9/50A61P3/10A61P13/12A61P5/50A61P3/06A61K35/644A61K33/04A61K35/747A61K35/744A61K31/385
CPCA61K9/282A61K9/5015A61K31/385A61K33/04A61K35/644A61K35/744A61K35/747A61K36/232A61K36/258A61K36/36A61K36/804A61K36/8945A61P3/06A61P3/10A61P5/50A61P13/12A61K2300/00
Inventor 童建华李正亮
Owner 浙江金童生物科技有限公司
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