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Graphene oxide-covalent organic framework material composite material, capillary electrochromatographic column and preparation method

A technology of covalent organic framework and capillary electrochromatography, applied in chemical instruments and methods, other chemical processes, chemical/physical processes, etc., can solve the problems of low separation degree and low separation efficiency of separation of sulfa drugs, and reach the scope of use Wide, large specific surface area, simple and convenient method

Active Publication Date: 2020-09-01
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At least one of the following technical problems can be solved: (1) the existing capillary electrophoresis separation of sulfonamides has a low degree of separation; (2) the separation efficiency is low

Method used

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  • Graphene oxide-covalent organic framework material composite material, capillary electrochromatographic column and preparation method
  • Graphene oxide-covalent organic framework material composite material, capillary electrochromatographic column and preparation method
  • Graphene oxide-covalent organic framework material composite material, capillary electrochromatographic column and preparation method

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preparation example Construction

[0048] The present invention also provides a kind of preparation method of graphene oxide-covalent organic framework material composite material, comprises the following steps:

[0049] Step 1: Ultrasonic dispersion of graphene oxide in the reaction solvent;

[0050] Step 2: Add trialdehyde phloroglucinol and dissolve it fully by ultrasonic to obtain the first mixed suspension;

[0051] Step 3: Centrifuge the first mixed suspension, remove the supernatant, and then add benzidine, catalyst and reaction solvent for ultrasonic reaction to obtain the second mixed suspension;

[0052] Step 4: Centrifuge the second mixed suspension, remove the supernatant, then add trialdehyde phloroglucinol, biphenylenediamine and a catalyst, add a reaction solvent for ultrasonic reaction, and obtain a graphene oxide-covalent organic The third mixed suspension of framework material;

[0053] Step 5: Cool the third mixed suspension to room temperature, centrifuge, remove the supernatant, wash the ...

Embodiment 1

[0084] This embodiment provides a kind of graphene oxide-covalent organic framework material composite material; The body is 30mg: 40mL: 50mg.

[0085] The preparation method of above-mentioned graphene oxide-covalent organic framework material composite material comprises the following steps:

[0086] Step 1: Ultrasound 30 mg of graphene oxide in 20 mL of a mixture of ethanol and tetrahydrofuran (the volume ratio of ethanol and tetrahydrofuran is 9:1) for 30 minutes to make it uniformly dispersed;

[0087] Step 2: Add 10.5 mg trialdehyde phloroglucinol, and ultrasonically dissolve it fully for 15 minutes to obtain the first mixed suspension;

[0088] Step 3: Centrifuge the first mixed suspension for 5 minutes, remove the supernatant, then add 15 mg of benzphenyl diamine, 0.1 mL of trifluoroacetic acid and 10 mL of reaction solvent for ultrasonic reaction for 10 minutes to obtain the second mixed suspension;

[0089] Step 4: Centrifuge the second mixed suspension for 5 minut...

Embodiment 2

[0093] This embodiment provides a capillary electrochromatographic column; the capillary electrochromatographic column includes a quartz capillary column and a stationary phase located in the quartz capillary column, and the preparation raw material of the stationary phase includes the graphene oxide-covalent organic framework material of the above-mentioned embodiment 1 composite material.

[0094] figure 1 Shown is the schematic diagram of the preparation method of the capillary electrochromatographic column, and the preparation method of the capillary electrochromatographic column comprises the following steps:

[0095] Step a: Dissolve 10 mg of graphene oxide-covalent organic framework material composite material in 5 mL of N,N-dimethylformamide, and disperse it by ultrasonication for 20 minutes to obtain the first mixed solution;

[0096] Step b: Add 50 mg of dehydrating agent and 0.1 mL of 3-aminopropyltriethoxysilane to 5 mL of the first mixed liquid, ultrasonically di...

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Abstract

The invention relates to a graphene oxide-covalent organic framework material composite material, a capillary electrochromatographic column and a preparation method, belongs to the technical field ofchemical synthesis and analysis, and solves the problems of low separation degree and low separation efficiency of the existing capillary electrophoresis method for separating sulfonamides. Raw materials for preparing the graphene oxide-covalent organic framework composite material comprise graphene oxide, a reaction solvent and a covalent organic framework material monomer. The capillary electrochromatographic column comprises a graphene oxide-covalent organic framework material composite material and a quartz capillary column. The capillary electrochromatographic column containing the graphene oxide-covalent organic framework material composite material is good in separation effect and wide in application range.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis and analysis, and in particular relates to a graphene oxide-covalent organic framework material composite material, a capillary electrochromatographic column and a preparation method. Background technique [0002] Sulfonamides are a class of artificially synthesized antibacterial drugs. Due to their wide antibacterial spectrum and low price, they are widely used in the field of medicine, especially as veterinary drugs. However, if it is used in excess, the drug will remain in the animal body, and enter the human body along the food chain, causing harm to the human body, and may even lead to drug resistance of bacteria. Therefore, it is particularly important to establish analytical methods for sulfonamides in environmental water samples and food of animal origin. At present, the method commonly used to separate sulfonamides is capillary electrophoresis, that is, capillary zone electrop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/20B01J20/282B01J20/285B01D15/08B01J20/30
CPCB01J20/282B01J20/285B01D15/08B01J20/20
Inventor 叶能胜蔡智敏
Owner CAPITAL NORMAL UNIVERSITY
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