Capsule containing rose fermentation liquor and preparation method thereof
A fermented liquid and rose technology, applied in the direction of medical preparations containing active ingredients, methods based on microorganisms, biochemical equipment and methods, etc., can solve the problems of single ingredients, ineffective effects, and low dosage, and achieve drug release Rapid, reduced dosage, improved stability
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[0046] The embodiment of the present invention also relates to the preparation method of the capsule, comprising the following steps:
[0047] (1) Ingredients: Put the rose fermented liquid, inulin, fructooligosaccharides and maltodextrin into the batching tank according to the weight ratio, and then add pure water;
[0048] In one embodiment of the present invention, the mass and volume ratio of rose fermented liquid, inulin, fructooligosaccharide and maltodextrin to pure water is (84-117kg): (8-12L).
[0049] (2) Stir and dissolve: control the temperature in the batching tank to 45-55°C, and stir until all components are mixed evenly;
[0050] (3) Sterilization and filtration: raise the temperature of the batching tank to 75-90°C, keep stirring to keep the temperature for sterilization for 30-40 minutes, and obtain a concentrated solution after filtration, preferably using a 5 μm filter element for impurity filtration.
[0051] (4) Freeze-drying: after the concentrated solu...
preparation example 1
[0078] 1) Rose fermentation substrate preparation: crush dried rosebuds and pass through a 100-mesh sieve, add water to prepare a mixed solution with a mass concentration of 10%, and sterilize at 121° C. for 15 minutes to obtain a rose fermentation substrate.
[0079] 2) Strain activation: Dip Bacillus natto CICC 10262 with a sterilized bamboo stick, streak on the solid activation medium according to the plate streak method, and invert aerobic culture in a constant temperature incubator at 37°C for 15 to 20 hours. The activated Bacillus natto CICC 10262 strain was obtained.
[0080] Dip Lactobacillus bulgaricus CICC 20271 with a sterilized bamboo stick, draw a line on the solid activation medium according to the plate streaking method, and culture it upside down in a constant temperature incubator at 37°C for 15-20 hours to obtain the activated Lactobacillus bulgaricus CICC20271 strain .
[0081] Saccharomyces cerevisiae CICC 1252 was dipped with sterilized bamboo sticks, str...
Embodiment 1
[0116] (1) Ingredients: put 80 parts of rose fermentation liquid, 5 parts of inulin, 5 parts of fructooligosaccharide and 10 parts of maltodextrin into the batching tank according to the weight ratio, and then add pure water;
[0117] Among them, inulin was purchased from Xi'an Haotian Biological Engineering Co., Ltd., fructooligosaccharides were purchased from Guangzhou Hongyi Food Additives Co., Ltd., and maltodextrin was purchased from Xi'an Dafengshou Biotechnology Co., Ltd. The quality of the above-mentioned rose fermented liquid, inulin, fructooligosaccharide and maltodextrin and the volume ratio to pure water are (84-117kg): (8-12L).
[0118] (2) Stir and dissolve: control the temperature in the batching tank to 50°C, and stir until all components are evenly mixed;
[0119] (3) Sterilization and filtration: raise the temperature of the batching tank to 80°C, keep stirring to keep the temperature for sterilization for 30 minutes, and obtain the concentrate after filterin...
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