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Mesoporous silica nano composite carrier, drug-loaded compound, application and pharmaceutical composition

A technology of mesoporous silica and mesoporous silica, which is applied in the field of medicine to achieve good therapeutic effects

Pending Publication Date: 2020-12-01
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of mesoporous silicon nanoparticles as chemotherapeutic drug carriers for transarterial chemoembolization of liver tumors has not been reported yet.

Method used

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  • Mesoporous silica nano composite carrier, drug-loaded compound, application and pharmaceutical composition
  • Mesoporous silica nano composite carrier, drug-loaded compound, application and pharmaceutical composition
  • Mesoporous silica nano composite carrier, drug-loaded compound, application and pharmaceutical composition

Examples

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preparation example Construction

[0058] Further, the embodiment of the present invention also provides a method for preparing the above-mentioned mesoporous silica nanocomposite carrier, including:

[0059] S1, preparing the nanocluster core;

[0060] Mix metal salts with weak acid and strong base salts and then carry out hydrothermal reaction; specifically, mix and dissolve iron salts, sodium acetate and trisodium citrate and react at 180-220°C for 8-12 hours; among them, iron salts It is ferric chloride; the mass ratio of ferric chloride, sodium acetate and trisodium citrate is 1:1.5-2.0:0.2-0.5. The use of the above-mentioned substances and proportions can be beneficial to the formation of nano-cluster cores, which in turn is beneficial to the formation of subsequent composite carriers, and setting weak acid and strong base salts such as sodium acetate and trisodium citrate can prevent the formation of nano-cluster cores from aggregating, so that the formed The nano-cluster core is dispersed, which in tur...

Embodiment 1

[0080] This embodiment provides a method for preparing a mesoporous silica nanocomposite carrier, including:

[0081] S1. Nano-cluster core:

[0082] Dissolve 0.8125g of ferric trichloride hexahydrate in 25ml of ethylene glycol, and observe the state of the solution after dissolving for 30min. Then, 1.5 g of sodium acetate and 0.325 g of trisodium citrate were added to the above solution, stirred by magnetic force for 1 h, and then ultrasonicated for 1 h. Afterwards, the obtained mixed solution was transferred to a polytetrafluoroethylene-lined stainless steel autoclave, heated to 200° C., and continued to react for 10 h. After cooling to room temperature, the obtained Fe 3 o 4 Nanoclusters were washed three times with ethanol.

[0083] S2. The organic mesoporous silica shell is wrapped in the core of the nanocluster;

[0084] 0.16g CTAB was dissolved in a mixed solution of 30mL ethanol, 75mL water and 1mL ammonia solution (mass concentration 25%). Simultaneously add 10....

Embodiment 2- Embodiment 3

[0092] The operation of the preparation method of the mesoporous silica nanocomposite carrier provided in Example 2-Example 3 is basically the same as the preparation method of the mesoporous silica nanocomposite carrier provided in Example 1, the difference is that the operating conditions are different, specifically as follows:

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Abstract

The invention relates to the technical field of medicine, in particular to a mesoporous silica nano composite carrier, a drug-loaded compound, application and a pharmaceutical composition. The mesoporous silica nano composite carrier comprises a nano-cluster core with magnetic imaging characteristics and an organic mesoporous silica shell wrapping the nano-cluster core, and the surface of the organic mesoporous silica shell is modified with optical imaging molecules. The mesoporous silica nano-composite carrier can effectively load active drugs, then has a good treatment effect on liver tumors, can be deposited at a high concentration locally on the tumors, then continuously releases the loaded active drugs, and further kills tumor cells. Meanwhile, after the composite carrier is loaded with the active drugs and enters a body, the multi-modal imaging effect is achieved by utilizing the characteristics of magnetic resonance imaging and optical imaging of the composite carrier, so that the release, the drug effect, the mechanism and the like of the drugs are effectively detected, and the composite carrier has important clinical identification and research significance.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a mesoporous silicon oxide nanometer composite carrier, a drug-loaded composite, an application and a pharmaceutical composition. Background technique [0002] Tumor imaging and targeted therapy based on nanotechnology are important components of tumor basic and clinical treatment. Traditional transarterial chemoembolization for liver tumors mainly uses transarterial delivery of chemotherapeutic drugs and lipiodol emulsifiers to achieve local chemotherapy and transarterial embolization for liver cancer. Through arterial blood supply arterial administration to achieve high drug concentration in the local tumor and block the blood supply of the tumor. However, due to the rapid drug release of the chemotherapy drug-iodol emulsifier, the local drug in the tumor flows out quickly with the blood circulation, resulting in a short duration of effective drug concentration in the tumor. ...

Claims

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Application Information

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IPC IPC(8): A61K49/10A61K49/00A61K31/704A61K47/24A61P35/00
CPCA61K49/10A61K49/0052A61K49/0002A61K49/0021A61K31/704A61K47/24A61P35/00
Inventor 刘丽
Owner NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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