Mesoporous silica nano composite carrier, drug-loaded compound, application and pharmaceutical composition
A technology of mesoporous silica and mesoporous silica, which is applied in the field of medicine to achieve good therapeutic effects
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[0058] Further, the embodiment of the present invention also provides a method for preparing the above-mentioned mesoporous silica nanocomposite carrier, including:
[0059] S1, preparing the nanocluster core;
[0060] Mix metal salts with weak acid and strong base salts and then carry out hydrothermal reaction; specifically, mix and dissolve iron salts, sodium acetate and trisodium citrate and react at 180-220°C for 8-12 hours; among them, iron salts It is ferric chloride; the mass ratio of ferric chloride, sodium acetate and trisodium citrate is 1:1.5-2.0:0.2-0.5. The use of the above-mentioned substances and proportions can be beneficial to the formation of nano-cluster cores, which in turn is beneficial to the formation of subsequent composite carriers, and setting weak acid and strong base salts such as sodium acetate and trisodium citrate can prevent the formation of nano-cluster cores from aggregating, so that the formed The nano-cluster core is dispersed, which in tur...
Embodiment 1
[0080] This embodiment provides a method for preparing a mesoporous silica nanocomposite carrier, including:
[0081] S1. Nano-cluster core:
[0082] Dissolve 0.8125g of ferric trichloride hexahydrate in 25ml of ethylene glycol, and observe the state of the solution after dissolving for 30min. Then, 1.5 g of sodium acetate and 0.325 g of trisodium citrate were added to the above solution, stirred by magnetic force for 1 h, and then ultrasonicated for 1 h. Afterwards, the obtained mixed solution was transferred to a polytetrafluoroethylene-lined stainless steel autoclave, heated to 200° C., and continued to react for 10 h. After cooling to room temperature, the obtained Fe 3 o 4 Nanoclusters were washed three times with ethanol.
[0083] S2. The organic mesoporous silica shell is wrapped in the core of the nanocluster;
[0084] 0.16g CTAB was dissolved in a mixed solution of 30mL ethanol, 75mL water and 1mL ammonia solution (mass concentration 25%). Simultaneously add 10....
Embodiment 2- Embodiment 3
[0092] The operation of the preparation method of the mesoporous silica nanocomposite carrier provided in Example 2-Example 3 is basically the same as the preparation method of the mesoporous silica nanocomposite carrier provided in Example 1, the difference is that the operating conditions are different, specifically as follows:
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