Method for synthesizing progesterone

Abstract

The invention discloses a method for synthesizing progesterone. The method comprises the following steps: S1, performing synthesis of a compound 2: taking a derivative of 4AD as a raw material, takinga derivative of 4AD as a compound 1, taking chloroalkane as a solvent, adding an aqueous solution of tetramethylpiperidine oxide, sodium bromide and sodium bicarbonate, and carrying out oxidation reaction with a sodium hypochlorite solution to obtain the compound 2; S2, synthesizing a compound 3, namely reacting the compound 2 with 1-(1-piperidyl) cyclohexene under the protection of nitrogen by taking acetonitrile as a solvent to obtain a compound 3; S3, performing synthesis of progesterone: taking chloroalkane as a solvent of the compound 3, adding a dimethylformamide solvent for dissolvingcuprous chloride, and carrying out post-treatment to obtain progesterone; and S4, performing purification of progesterone: refining and purifying progesterone by using dichloromethane and sodium hypochlorite. The invention mainly aims at a progesterone synthesis method, and the synthesis route has the advantages of cheap initial raw materials, simple reaction steps, mild reaction conditions, economy, environmental protection, and suitableness for industrial implementation.

Description

technical field [0001] The invention relates to the technical field of progesterone synthesis, in particular to a method for progesterone synthesis. Background technique [0002] The chemical name of progesterone is: 4-pregnene-3,20-dione. This product is a steroidal progesterone drug and an important hormone drug intermediate. It is mainly used for habitual abortion, dysmenorrhea, and menstrual bleeding. Polyuria or bleeding syndrome, amenorrhea, etc. Oral large doses are also used for diseases caused by progesterone deficiency, such as premenstrual syndrome, menstrual disorders caused by cessation of ovulation, benign breast disease, premenopause and menopause, etc. Vaginal administration can replace Oral administration, especially for patients with liver disease, can also be used for benign prostatic hyperplasia and sleep apnea syndrome. The traditional synthesis method is to obtain saponin from turmeric extract through multi-step reactions. [0003] With the increase of...

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Problems solved by technology

[0003] With the increase of labor cost and environmental protection pressure in China, the price of saponin is more than 800,000 yuan/ton, and the yield of this route is low. Compared with the invention patent application for the preparation method of progesterone CN104262442A, a preparation method of progesterone is disclosed. Specifically, 1,4-androstenedione is used as a raw material, and progesterone is obtained through a three-step reaction of synthesizing ether compounds, synthesizing nitro compounds, and synthesizing progesterone, and the cost is high; compared with CN103848879A, which uses 1,4-androstenedione The invention patent application for the method of preparing progesterone as a raw material discloses a preparation method of progesterone, specifically using 1,4-androstenedione as a raw material, first synthesizing the enol ether of 1,4-androstenedione, Then carry out Wittig reaction to obtain progesterone, compare the invention patent of a synthetic...

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