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Calcium phosphate and folic acid composite particles and preparation method and application thereof

A technology of calcium phosphate folic acid and composite particles, applied in phosphorus compounds, chemical instruments and methods, pharmaceutical formulations, etc., can solve the problems of high price, oxidative damage, and not very good ultraviolet filters, and achieve high dispersion, The effect of good biocompatibility

Active Publication Date: 2021-04-13
HUNAN YUJIA COSMETICS MFG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used inorganic powders such as zinc oxide are relatively expensive and are not very good UV filters
Titanium dioxide usually has residual catalytic activity, which can be activated and produce free radical precursors under the irradiation of light of a certain wavelength. Frequent use of titanium dioxide can lead to percutaneous absorption of titanium, resulting in possible oxidative damage
However, the UV protection ability of calcium phosphate still needs to be further strengthened to achieve better sun protection effect

Method used

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  • Calcium phosphate and folic acid composite particles and preparation method and application thereof
  • Calcium phosphate and folic acid composite particles and preparation method and application thereof
  • Calcium phosphate and folic acid composite particles and preparation method and application thereof

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preparation example Construction

[0033] The preparation method of calcium phosphate folic acid composite particles according to one embodiment of the present invention comprises the following steps S1-S4:

[0034] S1, such as figure 1 As shown, polycarboxy polymers (such as PAA) and calcium sources (such as Ca(OH) 2 ) react in water to obtain carboxyl / calcium ion complex solution.

[0035] S2. Add a poor solvent (such as IPA) to the carboxyl group / calcium ion complex solution to obtain a cloudy solution.

[0036] S3, adding a phosphate solution to the turbid solution to obtain calcium phosphate nanoparticles (PAA-CaPNPs) with carboxyl groups on the surface.

[0037] S4. Using a carboxyl activator to activate the carboxyl groups on the surface of the calcium phosphate nanoparticles, and then adding folic acid solution for amidation reaction to obtain calcium phosphate folic acid composite particles.

[0038] Folic acid, also known as pteroylglutamic acid, is a water-soluble B vitamin composed of pterin, p-a...

Embodiment 1

[0056] Preparation of calcium phosphate nanoparticles under different reaction concentrations of embodiment 1

[0057] In Example 1, the ratio of calcium hydroxide-polyacrylic acid-phosphate was fixed, and the concentration of reactants was changed under the condition of fixed reaction volume, so as to investigate the particle size and morphology of calcium phosphate nanoparticles under different reaction concentrations.

[0058] (a) Weigh 106.5 mg, 213 mg, and 416 mg of calcium hydroxide, respectively, and prepare 50 mL of aqueous solution. And based on the quality of calcium hydroxide, polyacrylic acid (284mg, 568mg, 1109mg) was configured with a calcium hydroxide: polyacrylic acid mass ratio of 3:8, and dissolved in water to obtain a 50mL aqueous solution. Calcium hydroxide aqueous solution was added dropwise into polyacrylic acid aqueous solution to initiate acid-base neutralization reaction. After stirring and mixing, a stable carboxyl group / calcium ion complex is formed...

Embodiment 2

[0071] Preparation of calcium phosphate nanoparticles under different polyacrylic acid concentrations of embodiment 2

[0072] In Example 2, the reaction concentration of calcium and phosphorus was fixed, and the content of polyacrylic acid was changed, so as to investigate the particle size and morphology of calcium phosphate nanoparticles.

[0073] (a) Weigh 106.5 mg of calcium hydroxide and configure it into 50 mL of aqueous solution. And according to the quality of calcium hydroxide as a benchmark, the mass ratio of calcium hydroxide: polyacrylic acid is 3:8, 3:4, 3:2 to configure polyacrylic acid (284mg, 142mg, 71mg), dissolved in water to obtain 50 mL of aqueous solution. Calcium hydroxide aqueous solution was added dropwise into polyacrylic acid aqueous solution to initiate acid-base neutralization reaction. After stirring and mixing, a stable carboxyl group / calcium ion complex is formed to form a clear and transparent aqueous solution, and the total volume of the aqueo...

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Abstract

The invention relates to a calcium phosphate folic acid composite particle and its preparation method and application, comprising the following steps: reacting a polycarboxy polymer and calcium source water to obtain a carboxyl / calcium ion complex solution; Add a poor solvent to the compound solution to obtain a turbid solution; add a phosphate solution to the turbid solution to obtain calcium phosphate nanoparticles with carboxyl groups on the surface; use a carboxyl activator to activate the carboxyl groups on the surface of the calcium phosphate nanoparticles, Then add folic acid solution, amidation reaction to obtain calcium phosphate folic acid composite particles. The calcium phosphate folic acid composite particle prepared by the present invention has high dispersibility and good biocompatibility. At the same time, the composite particle has both the ultraviolet scattering of inorganic powder and the ultraviolet absorption of folic acid molecule, and realizes ultraviolet protection through physical and chemical dual effects. , can be used in many fields such as cosmetic sunscreen agents, friction agents, concealers, etc.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a calcium phosphate folic acid composite particle and a preparation method and application thereof. Background technique [0002] Calcium phosphate is the main inorganic component in hard tissues of the human body, and mainly exists in hard tissues such as teeth and bones of the human body. Calcium phosphate has good biocompatibility to the human body, and has the advantages of no immunogenicity, no tumorigenicity, and no teratogenicity, so it is widely used in tissue engineering, nucleic acid carriers, drug adjuvants and other fields. Compared with other types of calcium phosphate with high crystallinity, amorphous calcium phosphate has higher solubility and excellent biodegradation characteristics. Its degradation metabolites are phosphate and calcium ions, which are inorganic substances required by the human body. Salt. Other metal oxides commonly used in the field of cosm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y40/00B82Y30/00A61K8/24A61K8/49A61K8/81A61K8/88A61Q17/04
CPCA61K8/24A61K8/4953A61K8/8147A61K8/88A61Q17/04B82Y30/00B82Y40/00C01B25/325C01P2002/84C01P2004/04C01P2004/62C01P2004/64
Inventor 戴跃锋何广文马晓瑜颜少慰
Owner HUNAN YUJIA COSMETICS MFG CO LTD