Phosphorus-containing nacreous coating and preparation method thereof

A nacre and coating technology, applied in the field of biomedical implant materials, achieves the effects of mature preparation technology, promotion of adhesion and proliferation, and good biocompatibility

Active Publication Date: 2021-01-19
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiencies in the prior art, the purpose of the present invention is to provide a phosphorous nacre coating and a preparation method thereof, which solves the problems of too fast degradation, The corrosion rate is too high and the corrosion range is not uniform, which leads to the problem of early failure of the material. A phosphorus-containing nacre coating material is provided. The phosphorus-containing nacre coating has high corrosion resistance, which is better than traditional magnesium alloys. The degradation rate is reduced, resulting in a slower uniform corrosion effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] Further, a preparation method of a phosphorus-containing nacre coating comprises the following steps:

[0034] S1. Pretreating the aluminum-magnesium alloy substrate;

[0035] S2. Prepare a phosphorus-containing nacre solution by Na2EDTA-assisted induction method;

[0036] S3, adjusting the pH value of the hydrothermal solution by NaOH to hydrothermally deposit on the surface of the aluminum-magnesium alloy substrate;

[0037] S4. After the hydrothermal reaction is completed, the furnace is cooled to room temperature, and the finished product is a magnesium alloy with a phosphorus-containing nacre coating on the surface.

[0038] As the pH value of the hydrothermal solution changes, the surface morphology of the phosphor-containing nacre coating obtained above shows a rod-like aggregation distribution or a granular aggregation distribution, and the composition of the surface coating changes from DCPA to HA. The OCP value is higher than the control group without coatin...

Embodiment 1

[0051] A phosphorus-containing nacre coating, the finished product is obtained by hydrothermally depositing pearl powder and NaH2PO4 through a reaction kettle under the condition of Na2EDTA-assisted induction to adjust the pH;

[0052] Described pearl powder is nanoscale pearl powder, and its particle diameter is less than 100nm;

[0053] The NaH2PO4 reagent and Na2EDTA reagent used above have a concentration of 0.5mol / L

[0054] The preparation method of above-mentioned a kind of phosphorus-containing nacre coating specifically comprises the steps:

[0055] (1) First, a magnesium alloy test piece of 10mm*10mm*3mm was prepared, and the surface was polished with 800#, 1200%, and 1500# sandpaper in turn, and after ultrasonic cleaning with absolute ethanol, the sample was placed in 800μL HNO3+100μL H2SO4+ Perform chemical polishing in a mixed solution of 10mL ultrapure water for 15s, and then dry it for use;

[0056] (2) Add 0.5mol / L Na2EDTA and pearl powder to 35mL ultrapure w...

Embodiment 2

[0062] A phosphorus-containing nacre coating, the finished product is obtained by hydrothermally depositing pearl powder and NaH2PO4 through a reaction kettle under the condition of Na2EDTA-assisted induction to adjust the pH;

[0063] Described pearl powder is nanoscale pearl powder, and its particle diameter is less than 100nm;

[0064] The NaH2PO4 reagent and Na2EDTA reagent used above have a concentration of 0.5mol / L

[0065] The preparation method of above-mentioned a kind of phosphorus-containing nacre coating specifically comprises the steps:

[0066] (1) First, a magnesium alloy test piece of 10mm*10mm*3mm was prepared, and the surface was polished with 800#, 1200%, and 1500# sandpaper in sequence, and after ultrasonic cleaning with absolute ethanol, the sample was placed in 800μL HNO3+100μL H2SO4+ Perform chemical polishing in a mixed solution of 10mL ultrapure water for 15s, and then dry it for use;

[0067] (2) Add 0.5mol / L Na2EDTA and pearl powder to 35mL ultrapu...

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Abstract

The invention discloses a phosphorus-containing nacreous coating, and the phosphorus-containing nacreous coating is formed on an AZ91D alloy substrate by hydrothermal deposition. The component of coating is pearl powder prepared by mixing pearl powder; 0.5mol / L of Na2EDTA as a Ca source, and 0.5mol / L of NaH2PO4 as a P source are mixed with 35mL of ultrapure water to form a turbid liquid; after magnetic stirring, the pH value of a hydrothermal solution is regulated with an NaOH solution; a pretreated AZ91D alloy and the hydrothermal reaction solution are put into a 50mL reaction kettle together; corresponding reaction temperature and holding time are set; and after the hydrothermal reaction ends, furnace cooling is performed to room temperature to obtain the phosphorus-containing nacreous coating. In order to solve the problem that the early failure of the material is caused by the fact that degradation is excessively fast, the corrosion rate is overhigh and the corrosion range is not uniform after the medical magnesium and magnesium alloy are implanted into a body, the invention provides the phosphorus-containing nacreous coating material; the phosphorus-containing nacreous coatinghas relatively high corrosion resistance; and the degradation speed of the magnesium alloy is reduced in comparison with that of a traditional magnesium alloy, so that a relatively slow uniform corrosion effect is achieved.

Description

technical field [0001] The invention relates to the technical field of biomedical implant materials, in particular to a phosphorus-containing nacre coating and a preparation method thereof. Background technique [0002] Currently, three inert metal implants, stainless steel, titanium alloy and cobalt-chromium alloy, are commonly used in clinics, while biodegradable metals such as magnesium, iron and zinc are also used in clinical research as a new generation of biomaterials. Among them, magnesium and its alloys, as biomedical materials, have the following advantages compared with the inert metal implants that have entered clinical application at present: (1) light weight, density similar to human bone, and elastic modulus, compressive strength and Compared with other implants, the value of tensile strength is closer to human bone, which can reduce the stress shielding effect between human bone and bone implant, and promote the formation of new bone; (2) has "biodegradability...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/32A61L27/28A61L27/50C22C23/04C22C23/02
CPCA61L27/047A61L27/32A61L27/28A61L27/50C22C23/04C22C23/02A61L2430/02A61L2300/112A61L2300/412A61L2300/606A61L2400/12
Inventor 何美凤谢晓明俞丹陆文兵杨胜明徐盛孝
Owner UNIV OF SHANGHAI FOR SCI & TECH
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