Levofloxacin hydrochloride quick release preparation and preparation method thereof

Abstract

The invention relates to the field of medicine processing, and discloses a levofloxacin hydrochloride quick release preparation and a preparation method thereof. The levofloxacin hydrochloride quick release preparation is prepared from the following components in parts by weight: 100mg-200mg of levofloxacin hydrochloride, 50mg-100mg of cross-linked PVP, 15mg-45mg of carboxymethyl starch sodium, 20-80mg of lactose, 1mg-10mg of aerosil and 1mg-2mg of magnesium stearate. The levofloxacin hydrochloride quick release preparation is prepared from the levofloxacin hydrochloride, a diluent, a disintegrating agent and a lubricating agent, wherein the diluent is the lactose, the disintegrating agent comprises the cross-linked PVP and the carboxymethyl starch sodium, and the lubricating agent is prepared from the aerosil and the magnesium stearate. According to the levofloxacin hydrochloride quick release preparation disclosed by the invention, a powder direct tabletting method is adopted, and the rapid disintegrating agent is added, so that the disintegration performance of the tablet prepared by the invention is not reduced due to early contact with moisture, the medicine exists in an extremely tiny particle, microcrystalline or molecular state, and the disintegrating agent promotes the tablet to disintegrate through capillary action or expansion action. Therefore, aiming at the prior art, the dissolution speed and bioavailability of the medicine can be improved, and the quick-acting and efficient effects are achieved.

Description

technical field [0001] The invention relates to the field of pharmaceutical processing, and relates to a preparation method of a quinolone antibiotic preparation, in particular to a levofloxacin hydrochloride fast-release preparation and a preparation method thereof. Background technique [0002] Levofloxacin hydrochloride is the left-handed body of ofloxacin, and its antibacterial activity is about twice that of ofloxacin. Its main mechanism of action is to inhibit the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hinder bacterial DNA replication. . It has the characteristics of broad antibacterial spectrum and strong antibacterial effect. For most Enterobacteriaceae, such as Escherichia coli, Klebsiella, Serratia, Proteus, Shigella, Salmonella, Citrobacter, Acinetobacter and Pseudomonas aeruginosa Gram-negative bacteria such as Monas, Haemophilus influenzae, and Neisseria gonorrhoeae have strong antibacterial activity. It also has a good antibacteria...

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Problems solved by technology

It also has a good antibacterial effect on Gram-positive bacteria such as methicillin-sensitive Staphylococcus, Streptococcus pneumoniae, Streptococcus pyogenes, and hemolytic streptococcus, as well as Legionella, Mycoplasma, and Chlamydia, but it has no effect on anaerobic bacteria and enterococci. poor

[0003] There are tablets and capsules of levofloxacin hydrochloride preparations on the market, but there is no quick-release preparation on the market