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Material with high biological safety, for nephrostomy tube

A biosafety and ostomy technology, used in catheters, drug delivery, pharmaceutical formulations, etc., can solve the problems of complex components, high cost, poor compatibility, etc., and achieve good biocompatibility, soft material, improved effect on survival

Inactive Publication Date: 2021-02-05
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The nephrostomy tube provided by this invention has improved flexibility, is easy to bend, has the advantages of good strength, large drainage, sterility and non-toxicity, but its components are complicated, the cost is high, and the compatibility between the components is not good, so it is easy to phase separation occurs

Method used

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  • Material with high biological safety, for nephrostomy tube

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A preparation method of a nephrostomy tube material, comprising the steps of:

[0033] Ⅰ Add 1.39 kg of 2,2-bis(4-isocyanatophenyl)hexafluoropropane, 1,3-bis(3-hydroxyisobutyl)tetramethyldisiloxane into a three-necked flask with a stirring device 1 kg of alkane, 0.3 kg of dibutyltin dilaurate, and 10 kg of dimethyl sulfoxide were stirred and reacted at 85°C for 10 hours under a nitrogen atmosphere. Ether is removed by rotary evaporation to obtain fluorosilicone polyurethane;

[0034] Ⅱ Add 1 kg of ethyl 3-[2-bromo-4-(trifluoromethyl)phenyl]-2-cyanoacrylate, 1 kg of [bis(trifluoromethylsulfonyl)amino]trimethylsilane, and 0.8 kg of sodium carbonate kg was added to 10 kg of hexafluoroisopropanol, stirred and reacted at 30°C for 8 hours, then filtered, the hexafluoroisopropanol was removed by rotary evaporation, and the product was washed with ether for 3 times, and then the ether was removed by rotary evaporation to obtain an intermediate product;

[0035] ⅢAdd 900g of t...

Embodiment 2

[0039] A preparation method of a nephrostomy tube material, comprising the steps of:

[0040]Ⅰ Add 1.39 kg of 2,2-bis(4-isocyanatophenyl)hexafluoropropane, 1,3-bis(3-hydroxyisobutyl)tetramethyldisiloxane into a three-necked flask with a stirring device 1kg of alkane, 0.35kg of stannous octoate and 12kg of N,N-dimethylformamide were stirred and reacted at 88°C for 10.5 hours under a helium atmosphere. times, after rotary evaporation to remove ether to obtain fluorosilicone polyurethane;

[0041] Ⅱ Add 1 kg of ethyl 3-[2-bromo-4-(trifluoromethyl)phenyl]-2-cyanoacrylate, 1 kg of [bis(trifluoromethylsulfonyl)amino]trimethylsilane, and 0.85 kg of potassium carbonate kg was added to 12 kg of tetrahydrofuran, stirred and reacted at 33°C for 8.5 hours, then filtered, the tetrahydrofuran was removed by rotary evaporation, and the product was washed 4 times with ether, and the ether was removed by rotary evaporation to obtain an intermediate product;

[0042] III Add 900g of the inter...

Embodiment 3

[0046] A preparation method of a nephrostomy tube material, comprising the steps of:

[0047] Ⅰ Add 1.39 kg of 2,2-bis(4-isocyanatophenyl)hexafluoropropane, 1,3-bis(3-hydroxyisobutyl)tetramethyldisiloxane into a three-necked flask with a stirring device 1kg of alkanes, 0.4kg of triethylamine and 13kg of N-methylpyrrolidone were stirred and reacted at 89°C for 11 hours under a neon atmosphere. Distillation removes ether to obtain fluorosilicone polyurethane;

[0048] Ⅱ Add 1kg of ethyl 3-[2-bromo-4-(trifluoromethyl)phenyl]-2-cyanoacrylate, 1kg of [bis(trifluoromethylsulfonyl)amino]trimethylsilane, sodium hydroxide Add 0.9 kg to 13 kg of hexafluoroisopropanol, stir and react at 35°C for 9 hours, then filter, remove hexafluoroisopropanol by rotary evaporation, wash the product with ether for 4 times, and then remove ether by rotary evaporation to obtain an intermediate product;

[0049] III Add 900g of the intermediate product prepared in step II, 300g of 1,2-epoxy-4-vinylcyclo...

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Abstract

The invention discloses a material with high biological safety, for nephrostomy tube. A preparation method of the material comprises the following steps: (1) preparing fluorosilicone polyurethane; (2)preparing an intermediate product; (3) preparing epoxy fluorine-containing sulfonyl ionic type polycyanoacrylate; and (4) forming the material for the nephrostomy tube. The material for the nephrostomy tube has a good hemostatic function, is excellent in strength and toughness, can improve the success rate of minimally invasive surgery such as nephrostomy on the premise that the economic burden of a patient is not obviously increased, reduces complications, increases the survival rate of the patient, and is good in use biological safety.

Description

technical field [0001] The invention relates to the technical field of nephrostomy, in particular to a material for a nephrostomy tube with a hemostatic function and a preparation method thereof. Background technique [0002] With the continuous development of modern medicine, nephrostomy is very important in the minimally invasive surgical treatment of pyonephrosis and kidney stones. It is one of the effective ways to drain the renal pelvis, improve renal function, and reduce infection of the renal pelvis and renal parenchyma. This kind of operation needs to puncture a channel on the kidney, and indwell a nephrostomy tube after the operation. The nephrostomy tube is an indispensable medical device used in the process of nephrostomy, and its performance and structure directly affect the Therefore, the development of a nephrostomy tube with excellent performance is an urgent task in the industry. [0003] Nephrostomy tube In nephrostomy, the percutaneous kidney is inserted i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/04A61L29/06A61L29/16
CPCA61L29/041A61L29/06A61L29/16A61L2300/404A61L2300/418A61L2400/04C08L75/04C08L33/14
Inventor 邓生卫万迎春
Owner 湖南博隽生物医药有限公司