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Carboxylic acids for treatment/prevention of dermatological conditions

A skin disease and carboxylic acid technology, applied in skin diseases, carboxylate preparation, carboxylate preparation and other directions, can solve problems such as skin thinning, achieve high penetration, improve skin aging and moisture retention, reduce storage effect of difficulty

Inactive Publication Date: 2021-03-09
沧州硕金生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Corticosteroid creams should be used carefully and as prescribed as they may cause thinning of the skin if overused over a long period of time

Method used

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  • Carboxylic acids for treatment/prevention of dermatological conditions
  • Carboxylic acids for treatment/prevention of dermatological conditions
  • Carboxylic acids for treatment/prevention of dermatological conditions

Examples

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preparation example Construction

[0040] A method for preparing a hydrogel containing carboxylic acid, wherein the carboxylic acid comprises carboxylic acid or a pharmaceutically acceptable salt thereof, comprising:

[0041] Provide carboxylic acid, including 2-10 carbon atoms in the above-mentioned carboxylic acid;

[0042] Liposomes are provided, wherein the liposomes include 1-10 wt% of the above-mentioned carboxylic acid and 0.5-1.5 wt% of zinc conjugated linoleic acid;

[0043] providing a gel matrix so that the above-mentioned liposomes are gelled; the above-mentioned gelation operation is carried out under alkaline conditions, and the preferred pH is 7-8;

[0044] The zinc salt of conjugated linoleic acid is synthesized by conjugated linoleic acid and zinc chloride in the presence of sodium cyclamate and p-methoxyaniline.

[0045] In the present invention, the active ingredient containing carboxylic acid is delivered to the skin in the form of hydrogel, and the ductility of hydrogel is used to improve th...

Embodiment 1

[0073] A kind of preparation method of hydrogel containing carboxylic acid, its concrete steps are as follows:

[0074] (1) Gel matrix preparation: take carbomer 940 and poloxamer 407 and put them in glycerin for 60 minutes, add deionized water and stir evenly, swell overnight for 12 hours, then add azone, ethylparaben and EDTA Disodium is mixed on a magnetic stirrer to obtain a gel matrix, which is for subsequent use. The weight percentage content of each substance in the gained gel matrix is ​​as follows: carbomer 9400.35%, poloxamer 407 17.5%, glycerin 12%, Azone 1.5%, Ethylparaben 0.25%, Disodium EDTA 0.1%;

[0075](2) Preparation of sodium salt of conjugated linoleic acid: at 10°C under nitrogen protection, add an equivalent amount of conjugated linoleic acid to a sodium hydroxide ethanol solution with a mass concentration of 12.5%, and then add cyclamic acid Sodium and p-methoxyaniline were stirred and reacted for 4 hours to obtain a sodium salt solution of conjugated l...

Embodiment 2

[0081] A method for preparing a carboxylic acid-containing hydrogel, repeating the steps of Example 1, the difference is that in step (5) liposome preparation, when adding carboxylic acid, the weight ratio in the oil phase is also added They are respectively: 2.5wt% vitamin E, 0.5wt% cucurbitacin and 1wt% bisabolol.

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Abstract

The present invention provides a carboxylic acid for treating / preventing dermatosis, belonging to the field of biotechnology, in which the carboxylic acid is delivered in the form of a carboxylic acid-containing hydrogel, the preparation method thereof comprising: providing a carboxylic acid comprising 2-10 carbon atoms; providing a liposome containing a carboxylic acid and a conjugated zinc linoleate salt; providing a gel matrix so that the lipidosome is gelatinized under an alkaline condition; the conjugated linoleic acid zinc salt is synthesized from conjugated linoleic acid and zinc chloride in the presence of sodium cyclamate and p-anisidine. According to the preparation method of the hydrogel provided by the invention, the reaction yield and the high-temperature stability of the conjugated zinc linoleate can be improved, and the storage difficulty of the zinc salt and the hydrogel is reduced; the absorptivity and the availability of carboxylic acid can be improved by utilizing the ductility of the hydrogel, the percutaneous penetration efficiency of the liposome is improved, and high penetration amount and high in-skin storage property are obtained; the obtained product can be used for treating / preventing skin diseases and enhancing the skin immune function and the allergen exposure protection capability.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a carboxylic acid used for treating / preventing skin diseases. Background technique [0002] Skin disease is one of the most common diseases in humans. In recent years, with the rapid development of my country's urbanization and economy, urban ambient air pollution is relatively serious. Ambient air pollution has caused various hazards to the health of adults and children, especially prone to skin diseases such as skin infections. Furthermore, skin allergies due to contact with allergens are increasingly common in humans. Although different types of skin conditions have different symptoms, they all share certain symptoms, including skin redness, swelling, itching, skin lesions, and sometimes oozing and scarring. [0003] Diseases such as: (1) Atopic contact dermatitis: Skin reactions can be managed as follows: clean the area of ​​skin that came into contact with the chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/19A61K31/191A61K31/201A61K33/30A61K47/10A61K47/32A61P17/00A61P17/16A61P17/18C07C51/41C07C57/12
CPCA61K9/0014A61K9/06A61K31/19A61K31/191A61K31/201A61K33/30A61K47/10A61K47/32A61P17/00A61P17/16A61P17/18C07C51/412C07C57/12A61K2300/00
Inventor 不公告发明人
Owner 沧州硕金生物科技有限公司
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