Photo-thermal rapid controlled-release nano-drug and preparation method thereof
A nano-drug and fast technology, applied in the field of controlled-release nano-drug and its preparation, can solve the problems of poor therapeutic effect and slow rate, and achieve the effect of improving drug utilization efficiency and improving therapeutic effect
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Embodiment 1
[0027] 1) furanization (PCL-Fur) of polycaprolactone: get 0.5 mmol of polycaprolactone (molecular weight is 5K Da) and dissolve in acetone, then add potassium carbonate, n-tetrabutylammonium bromide and Dibromomethylfuran was heated under reflux at 65°C for 48 hours to obtain polycaprolactone PCL-Fur with a furyl group at one end;
[0028] 2) Preparation of carrier (PCL-DA-PEG): Take 0.1 mmol of PCL-Fur and 0.1 mmol of maleimide-based polyethylene glycol (molecular weight 5K Da), add to N,N-dimethyl In a formamide solvent, heat and stir at 40° C. for 48 hours to obtain a PCL-DA-PEG carrier.
[0029] 3) Preparation of photothermal rapid controlled-release nanomedicine: Take PCL-DA-PEG, doxorubicin and copper sulfide nanoparticles in a mass ratio of 10:5:3 and dissolve them in dichloromethane, and drop them into into 10 times the volume of deionized water, after ultrasonic emulsification, the dichloromethane in the system was removed by rotary evaporation, and after centrifugal...
Embodiment 2
[0031] 1) furanization (PCL-Fur) of polycaprolactone: get 0.5 mmol of polycaprolactone (molecular weight is 2K Da) and dissolve in acetone, add potassium carbonate, n-tetrabutylammonium bromide and Dibromomethylfuran was heated under reflux at 60°C for 40 hours.
[0032] 2) Preparation of carrier (PCL-DA-PEG): Take 0.1mmol of PCL-Fur and 0.12mmol of maleimide-based polyethylene glycol (molecular weight 2K Da), add to N,N-dimethyl In a formamide solvent, heat and stir at 30° C. for 40 hours to obtain a PCL-DA-PEG carrier.
[0033] 3) Preparation of photothermal rapid controlled-release nanomedicine: Take PCL-DA-PEG, doxorubicin, and gold nanorods in a mass ratio of 10:2:2 and dissolve them in dichloromethane, and drop them into the 10 times the volume of deionized water, after ultrasonic emulsification, the dichloromethane in the system was removed by rotary evaporation, and after centrifugal cleaning, freeze-dried to obtain nano drug powder with a particle size of about 70nm....
Embodiment 3
[0035] 1) furanization (PCL-Fur) of polycaprolactone: get 0.5 mmol of polycaprolactone (molecular weight is 5K Da) and dissolve in acetone, add potassium carbonate, n-tetrabutylammonium bromide and Dibromomethylfuran was heated under reflux at 70°C for 50 hours.
[0036] 2) Preparation of the carrier (PCL-DA-PEG): Take 0.1 mmol of PCL-Fur and 0.11 mmol of maleimide-based polyethylene glycol (molecular weight 2K Da), add to N,N-dimethyl In a formamide solvent, heat and stir at 50° C. for 50 hours to obtain a PCL-DA-PEG carrier.
[0037] 3) Preparation of photothermal rapid controlled-release nanomedicine: Take PCL-DA-PEG, paclitaxel, and gold nanorods in a mass ratio of 10:5:3 and dissolve them in dichloromethane. After fully dissolving, drop them into 8 times volume of deionized water, after ultrasonic emulsification, the dichloromethane in the system was removed by rotary evaporation, and after centrifugal cleaning, freeze-dried to obtain nano drug powder with a particle siz...
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