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Turmeric whole extract nanoemulsion solid preparation and preparation method thereof

A technology of solid preparations and nanoemulsions, applied in food ingredients as emulsifiers, food science, pharmaceutical formulations, etc., can solve problems such as harsh process equipment and conditions, difficult industrial transformation and application, poor absorption, etc., and achieve active ingredient content and activity High, low requirements for production equipment, uniform and non-layered effect

Active Publication Date: 2021-04-30
PERFECT CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw material powder of curcumin has a crystalline structure, its solubility in water is low, its absorption in the body is poor, it is sensitive to light, heat, and acid-base environmental factors, and it is easy to decompose and fail. Therefore, improving the water solubility and stability of curcumin has become a research hotspot and application breakthrough point
[0003] There are many literature and patent reports on improving the dissolution and absorption of curcumin. Due to the harsh process equipment and conditions, most of the research is difficult to achieve industrial transformation and application. Patent CN106667912A discloses a curcumin nanoemulsion with a particle size of 1-10nm And its preparation method requires high equipment
At present, the research mainly uses curcumin as raw material to modify or reduce its particle size to achieve uniform dispersion and improve solubility. There is no public research on emulsification and dispersion of curcumin as raw material through extraction and other processes. At the same time, research reports mainly Polylactic acid, poloxamer and other polymer materials are used to study the solubilization of curcumin by nano-embedding, solid dispersion, inclusion technology, reverse micellar system and modification. However, the solubilizing materials used are not listed Solubilized food additives that are allowed to be used, do not meet the requirements of my country's food-related laws and regulations

Method used

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  • Turmeric whole extract nanoemulsion solid preparation and preparation method thereof
  • Turmeric whole extract nanoemulsion solid preparation and preparation method thereof
  • Turmeric whole extract nanoemulsion solid preparation and preparation method thereof

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Embodiment 1

[0038] An embodiment of the nanoemulsion solid preparation of turmeric whole extract of the present invention is composed of the following components in mass fraction: curcumin 20%, turmeric essential oil 0.5%, turmeric polysaccharide water-soluble matter 15%, monoglyceride fatty acid ester 15% and the balance maltodextrin.

[0039] The preparation method of the whole curcuma longa extract nanoemulsion solid preparation described in the present embodiment comprises the following steps:

[0040] (1) Preparation of whole turmeric extract

[0041] S1. Take the turmeric medicinal material and pulverize it, and pass through a 60-mesh sieve to obtain the turmeric medicinal material powder;

[0042] S2. Take the turmeric medicinal material powder obtained in S1, add 70% ethanol aqueous solution according to the ratio of solid to liquid 1:10, soak for 15 minutes, heat and reflux at 70°C for 2.0 hours, and extract twice. After filtering through a 100-mesh filter bag, centrifuge at 50...

Embodiment 2

[0050] An embodiment of the nanoemulsion solid preparation of turmeric whole extract of the present invention is composed of the following components in mass fraction: 10% curcumin, 1% turmeric essential oil, 10% turmeric polysaccharide water-soluble matter, sucrose fatty acid ester and Soy lecithin (sucrose fatty acid ester: soybean lecithin = 10:1, mass ratio) 10% and the balance maltodextrin.

[0051] The preparation method of the whole curcuma longa extract nanoemulsion solid preparation described in the present embodiment comprises the following steps:

[0052] (1) Preparation of whole turmeric extract

[0053] S1. Take the turmeric medicinal material and pulverize it, and pass through a 40-mesh sieve to obtain the turmeric medicinal material powder;

[0054] S2. Take the turmeric medicinal material powder obtained in S1, add 65% ethanol aqueous solution according to the ratio of solid to liquid 1:12, soak for 15 minutes, heat and reflux at 65°C for 1.5 hours, and extrac...

Embodiment 3

[0062] An embodiment of the nanoemulsion solid preparation of turmeric whole extract of the present invention is composed of the following components in mass fraction: 30% curcumin, 0.5% turmeric essential oil, 12% turmeric polysaccharide water-soluble matter, sucrose fatty acid ester and Monoglyceride fatty acid ester 12% (sucrose fatty acid ester: monoglyceride fatty acid ester=3:4, mass ratio) and the balance maltodextrin.

[0063] The preparation method of the whole curcuma longa extract nanoemulsion solid preparation described in the present embodiment comprises the following steps:

[0064] (1) Preparation of whole turmeric extract

[0065] S1. Take the turmeric medicinal material and pulverize it, and pass through a 40-mesh sieve to obtain the turmeric medicinal material powder;

[0066] S2. Take the turmeric medicinal material powder obtained in S1, add 70% ethanol aqueous solution according to the ratio of solid to liquid 1:12, soak for 20 minutes, heat and reflux at...

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Abstract

The invention discloses a preparation method of a turmeric whole extract nanoemulsion solid preparation, and belongs to the field of medicine and food preparation. The method extracts a whole extract from turmeric, and the obtained product is high in purity and high in raw material utilization rate; the nano-emulsion solid preparation is prepared by mixing the parts by adopting a homogenizing method and the like. The method is suitable for industrial large-scale production, and the defect of high-temperature curcumin degradation in the prior art is avoided. The invention also provides the curcuma longa whole extract nanoemulsion solid preparation prepared by the preparation method. The curcumin whole extract nano-emulsion solid preparation comprises curcumin, curcumin essential oil and curcumin polysaccharide water-soluble substances as parts and is high in content, and the curcumin whole extract nano-emulsion solid preparation is few in impurity, uniform in size, high in solubility and excellent in curcumin embedding rate, storage stability and in-vivo absorptivity. The invention also provides an application of the curcuma longa whole extract nano-emulsion solid preparation in preparation of medicaments and foods.

Description

technical field [0001] The invention relates to the field of medicine and food preparation, in particular to a nano-emulsion solid preparation of turmeric whole extract and a preparation method thereof. Background technique [0002] Curcumin (curcumin) is a polyphenolic compound extracted from the rhizomes of Zingiberaceae and Araceae plants. It has anti-oxidation, anti-inflammation, anti-tumor, delays senile dementia, diabetes, lowers blood lipids and other effects, and has anti-diabetic complications. The preventive and mitigating effects are called "plant gold" by the industry. Clinical studies have confirmed that eating large doses of curcumin still shows high safety and very little toxicity. It is widely used as food coloring all over the world. The raw material powder of curcumin has a crystalline structure, its solubility in water is low, its absorption in the body is poor, it is sensitive to light, heat, and acid-base environmental factors, and it is easy to decompo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/14A61K47/36A61K47/26A61K47/24A61K47/12A61K36/9066A23L29/10A23L29/30A23L33/105A23L33/125A23P10/47A61K31/12A61K31/715
CPCA61K9/1075A61K47/14A61K47/36A61K47/26A61K47/24A61K47/12A61K36/9066A61K31/12A61K31/715A23L33/105A23L33/125A23L29/10A23L29/30A23L29/35A23L29/37A23P10/47A23V2002/00A61K2300/00A23V2200/30A23V2250/2112A23V2250/51A23V2200/222Y02A50/30
Inventor 李晓敏严建刚喻亮欧阳道福王志芳孙忠伟魏毅凡古润金
Owner PERFECT CHINA
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