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Porous spherical carbon adsorption material with blood compatibility and preparation method of porous spherical carbon adsorption material

A blood-compatibility, porous spherical technology, applied in carbon preparation/purification, blood circulation treatment, chemical instruments and methods, etc., can solve problems such as uneven dispersion, inability to exert adsorption performance, and large pressure difference

Active Publication Date: 2021-05-18
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Hollow carbon microspheres have a well-developed pore structure, and also have good chemical and thermal stability. There are many preparation methods, among which the template method is currently widely used, but there are still some shortcomings in the existing synthesis process: For example, the template preparation process is cumbersome and the dispersion is uneven; it is necessary to accurately add surfactants, pore expanders, etc. in multiple steps; and the prepared hollow carbon microspheres are mostly wall-adhesive, and the monodispersity is poor.
At present, it is reported that two-dimensional materials such as graphene are combined with hollow carbon microspheres to prepare macroscopic bodies (Sep. Purif. Technol. 2019, 15, 524). However, in this method, on the one hand, graphene is easy to Coating the surface of the hollow carbon microspheres makes the well-developed pores of the carbon microspheres blocked, and the hollow carbon microspheres only play the role of supporting the skeleton, and its excellent adsorption performance cannot be exerted; on the other hand, the obtained massive random Airgel not only has low strength, but also it is difficult for blood to flow through the middle in actual hemoperfusion, which will generate a large pressure difference, and the sharp edges and corners are easy to damage normal cells, resulting in poor blood compatibility, etc., and cannot be used in blood. Perfusion application

Method used

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  • Porous spherical carbon adsorption material with blood compatibility and preparation method of porous spherical carbon adsorption material
  • Porous spherical carbon adsorption material with blood compatibility and preparation method of porous spherical carbon adsorption material
  • Porous spherical carbon adsorption material with blood compatibility and preparation method of porous spherical carbon adsorption material

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Experimental program
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Effect test

Embodiment 1

[0051] 1) Prepare a mixed solution of methyl orthosilicate, ethanol, ammonia water and water, stir at 750rpm at 20°C for 180min, then add resorcinol and formaldehyde, the reaction conditions remain unchanged, continue to stir, and after fully reacting for 21h, add The solution is centrifuged, filtered, washed and dried to obtain carbon / silicon composite microspheres;

[0052] 2) Put carbon / silicon composite microspheres into a tube furnace for carbonization, use an argon atmosphere, heat up to 700°C at a heating rate of 5°C / min, and then hold for 3 hours;

[0053] 3) Prepare a sodium hydroxide solution with a molar concentration of 1 mol / L, put 1 g of the carbonized sample into 300 mL of sodium hydroxide solution, condense and reflux at 80 ° C for 3 hours, and filter the solution after fully reacting, washing and drying to obtain Hollow carbon microspheres;

[0054] 4) configure the hollow carbon microsphere dispersion of 0.5wt% concentration, add dodecyl dimethyl betaine, an...

Embodiment 2

[0059] 1) Prepare a mixed solution of tetraethyl orthosilicate, ethanol, ammonia water, resorcinol, formaldehyde and water, stir at 750rpm at 35°C, and centrifuge the solution after fully reacting for 24 hours, suction filter, wash and dry Obtain carbon / silicon composite microspheres;

[0060] 2) Put carbon / silicon composite microspheres into a tube furnace for carbonization, use an argon atmosphere, heat up to 700°C at a heating rate of 3°C / min, and then hold for 5 hours;

[0061] 3) Prepare a sodium hydroxide solution with a molar concentration of 1 mol / L, put 1 g of the carbonized sample into 300 mL of sodium hydroxide solution, condense and reflux at 90 ° C for 2 hours, and filter the solution after fully reacting, washing and drying to obtain Hollow carbon microspheres;

[0062] 4) configure a chitosan solution with a concentration of 3wt%, and simultaneously configure a dispersion of hollow carbon microspheres with a concentration of 0.2wt%, add dodecyl sulfopropyl beta...

Embodiment 3

[0067] 1) Prepare a mixed solution of tetraethyl orthosilicate, ethanol, ammonia water and water, stir at 500rpm at 10°C for 30 minutes, then add catechol and formaldehyde, keep stirring under the same reaction conditions, and then add catechol and formaldehyde after fully reacting for 18 hours The solution is centrifuged, filtered, washed and dried to obtain carbon / silicon composite microspheres;

[0068] 2) Put carbon / silicon composite microspheres into a tube furnace for carbonization, use an argon atmosphere, heat up to 700°C at a heating rate of 2°C / min, and then keep warm for 2 hours;

[0069] 3) Prepare a potassium hydroxide solution with a molar concentration of 1 mol / L, put 1 g of the carbonized sample into 300 mL of potassium hydroxide solution, condense and reflux at 85°C for 2 hours, and filter the solution after fully reacting, washing and drying to obtain Hollow carbon microspheres;

[0070] 4) Prepare a sodium alginate solution with a concentration of 3wt%, and...

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Abstract

The invention discloses a porous spherical carbon adsorption material with blood compatibility, and belongs to the technical field of material preparation. The porous spherical carbon adsorption material is composite carbon spheres; the composite carbon spheres are formed by self-assembling single-layer or multi-layer hollow carbon microspheres under the action of a binder. The multi-level pore structure is as follows: a first-level pore structure is micron-level radial pore channels leading to the interior of the spheres from the surfaces of the composite carbon spheres; the second-level pore structure is submicron-level pore structures connecting the macropore channels in the composite carbon spheres; the pore walls of the first-level pore structure and the second-level pore structure are formed by compounding the hollow carbon microspheres and the binder; the third-level pore structure is a nano-scale pore structure of the hollow carbon microspheres forming the composite carbon spheres. The porous spherical carbon adsorption material has good adsorption performance on various adsorption substances, especially has unique and excellent adsorption performance on medium and macromolecular toxins, has good blood compatibility, and has good application prospects in the adsorption fields of blood purification, water treatment and the like.

Description

technical field [0001] The invention belongs to the technical field of material preparation, in particular to a porous spherical carbon adsorption material with blood compatibility and a preparation method thereof. Background technique [0002] Hemoperfusion refers to the introduction of the patient's blood outside the body through specific equipment. In the extracorporeal circulation system, the adsorbent in the hemoperfusion device removes various toxins in the blood that cannot be metabolized by the patient, especially the medium and large toxins that cannot be removed by hemodialysis. Molecular toxins, which play an irreplaceable and important role in the treatment of uremia, acute poisoning and immune system diseases. At present, the hemoperfusion adsorbent mainly represented by activated carbon in the domestic market, although it has a relatively high specific surface area, is mainly composed of micropores below 2nm, and hardly adsorbs or absorbs medium and large molec...

Claims

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Application Information

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IPC IPC(8): B01J20/20B01J20/28B01J20/30C01B32/05C02F1/28A61M1/38
CPCB01J20/20B01J20/28054B01J20/28059B01J20/28061B01J20/28069B01J20/28016B01J20/28004A61M1/38C02F1/283C01B32/05
Inventor 巩前明李愉珧杜锴
Owner TSINGHUA UNIV
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