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Absorbable expansion type nano short fiber powdery material as well as preparation method and application thereof

A technology for absorbing swelling and powdery materials, applied in applications, pharmaceutical formulations, medical science, etc., can solve the problems of high tap density hemostatic powder, fracture, etc., and achieve excellent flow properties, ultra-high tap density, and good water absorption.

Active Publication Date: 2021-07-16
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for the fiber material prepared by electrospinning, because the fiber material is too thin, it is difficult to break through rolling, and the ball milling method in the prior art cannot obtain a hemostatic powder with both high tap density and high fluidity

Method used

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  • Absorbable expansion type nano short fiber powdery material as well as preparation method and application thereof
  • Absorbable expansion type nano short fiber powdery material as well as preparation method and application thereof
  • Absorbable expansion type nano short fiber powdery material as well as preparation method and application thereof

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preparation example Construction

[0034] In a second aspect, the present invention provides a preparation method according to the first aspect of the present invention, the method comprising the following steps:

[0035] (1) Electrospinning step: preparing the nanofiber material from the fiber material by electrospinning;

[0036] (2) Crosslinking treatment step: the nanofiber material is modified and crosslinked to obtain a modified nanofiber material; preferably, the chemical crosslinking agent selected for the modified crosslinking treatment is selected from carbodiimide, One or more of the group consisting of carbodiimide / N-hydroxysuccinimide, genipin and aldehydes;

[0037](3) shearing treatment step: performing shearing treatment on the modified nanofiber material to obtain fluffy nano short fiber clusters;

[0038] (4) Preforming treatment: the fluffy nano-short fiber clusters are crystallized by liquid nitrogen low-temperature forming treatment so as to maintain a three-dimensional space network struc...

Embodiment 1

[0082] (1) Dissolving gelatin (Gelatin) in trifluoroethanol, wherein the mass concentration of gelatin is 6% (g / mL), stirring and dissolving to obtain a uniform polymer solution, which is the spinning stock solution. The polymer solution is placed in the electrospinning syringe, the speed of the micro-injection pump is adjusted to 5mL / h, the voltage of the high voltage generator is adjusted to 25kV, the receiving distance of the receiving device is adjusted to 12cm, and the relative humidity of the spinning environment is set to 40%, the ambient temperature is 30°C, and the electrospinning is carried out. Through the high-voltage electrospinning technology, the nanofiber material which is interwoven by fiber filaments and has a porous structure is prepared.

[0083] (2) In a 500mL beaker, add 225mL of absolute ethanol solution, then add 25mL of aqueous solution, stir and mix well, then weigh 3.57g of carbodiimide and 1.43g of N-hydroxysuccinimide and dissolve them in the above...

Embodiment 2

[0088] (1) Dissolve the hydroxypropylmethylcellulose (HPMC) material in a mixed solution of hexafluoroisopropanol and water, wherein the concentration of hydroxypropylmethylcellulose is 10% (g / mL), stir and dissolve A homogeneous polymer solution was obtained. At the same time, a certain mass of fibrinogen (coagulation factor) was weighed and dissolved in the above polymer solution. The polymer solution is placed in the electrospinning syringe, the speed of the micro-injection pump is adjusted to 5mL / h, the voltage of the high voltage generator is adjusted to 38kV, the receiving distance of the receiving device is adjusted to 10cm, and the relative humidity of the spinning environment is set to 30%, the ambient temperature is 40°C, electrospinning is carried out, and the porous nanofiber material composited with coagulation factors is prepared through high-voltage electrospinning technology.

[0089] (2) In a 500mL beaker, add 150mL of anhydrous isopropanol solution, then add...

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Abstract

The invention relates to an absorbable expansion type nano short fiber powdery material. The absorbable expansion type nano short fiber powdery material comprises nano short fibers and hydrophilic factors; the diameter of the nano short fiber is 500-5000 nm, and the length of the nano short fiber is 0.1-10 mm; and the hydrophilic factor is a high polymer material containing a hydrophilic carboxymethyl group. The invention further relates to a preparation method and application of the material. According to the absorbable expansion type nano short fiber powdery material, the expansion volume can reach 10 times or above of the self-volume, and the saturated water absorption rate is 1500%-5000%, the tap density is 0.1-1.0 g / mL; and the absorbable expansion type nano short fiber powdery material has good water absorption performance, expansion effect and biocompatibility, can be degraded and absorbed by tissues in a body, and can be applied to the fields of in-situ filling after tumor excision at a brain or other parts or filling for other tissue lacunae, or the fields of tissue errhysis or substantive visceral organ errhysis and the like.

Description

technical field [0001] The invention relates to an absorbable and expandable nano-short fiber powder material, a preparation method and application thereof, and belongs to the field of biomedical materials. Background technique [0002] With the increase of accidents such as traffic accidents and surgical operations, medical hemostatic materials have attracted close attention from the medical community. [0003] There are many kinds of commonly used hemostatic materials, such as fibrin glue, thrombin powder, gelatin sponge, collagen sponge, chitosan sponge, oxidized cellulose, microfibril collagen, alginate fiber, zeolite, cyanoacrylate, plant polysaccharide powder. [0004] Moreover, these commonly used hemostatic materials are also in various forms, including powder form, liquid form, film form and sponge form, etc. Powdered forms include, for example, lyophilized thrombin powder, plant polysaccharide powder, zeolite powder, microfibrillar collagen powder, and the like. ...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/104A61L24/102A61L24/08A61L24/0042A61L24/0015A61L24/001A61L2400/04A61L2400/12A61L2300/404A61L2300/418A61L2300/414C08L89/00C08L5/08C08L1/04C08L1/286C08L3/02
Inventor 李林静张莹莹邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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