Gradient material for promoting cartilage calcification layer repair and preparation method

A gradient material and cartilage calcification technology, which is applied in the field of biomedical implant materials to achieve the effect of promoting the regeneration of the calcified layer and the repair and reconstruction of the calcified layer.

Active Publication Date: 2021-10-01
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The gradient material for promoting the repair of cartilage calcified layer not only solves the functions of long-term anti-inflammatory, antibacterial and promoting the regeneration and repair of calcified layer, synergistically enhances the healing of subchondral bone and cartilage layer, but also s

Method used

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  • Gradient material for promoting cartilage calcification layer repair and preparation method
  • Gradient material for promoting cartilage calcification layer repair and preparation method
  • Gradient material for promoting cartilage calcification layer repair and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] 1) Add magnesium and zinc co-doped wollastonite powder with a particle size distribution of 0.20 to 1.25 microns (contents of magnesium and zinc are 0.95% and 0.62% respectively) to hyaluronic acid with a mass ratio of 3:7 - Stir evenly in the gelatin composite aqueous solution, the mass ratio of ceramic powder to organic matter is 1:8, prepare an organic-inorganic composite solution with a ceramic powder concentration of 12.5mg / ml, and then transfer to the stock solution of high-voltage electrospinning In the pool, the spinning distance is set to be 12 cm, the spinning voltage is 14 kV, and the electrospinning is carried out at a speed of 0.7 ml / h. When the thickness of the fiber film on the porous aluminum foil drum carrier reaches 100 microns, the electrospinning is stopped;

[0086] 2) Transfer the solution containing 6% poly-L-lactide-caprolactone (PLCL) to the electrospinning equipment reservoir in the above step 1, set the spinning distance to 15 cm, and the spinn...

Embodiment 2

[0090] 1) Bioglass powder with a particle size of 0.10-0.65 microns (chemical composition 28CaO-42SiO 2 -12B 2 o 3 -4P 2 o 5 -6MgO-1CuO-2ZnO-4Na 2 O-1K 2 O) join in the organic polymer solution that contains 6% gelatin-4% polyethylene sulfonic acid and fully stir, and the mass ratio of inorganic particle and organic polymer is 1:15, is mixed with the biological glass particle concentration and is 18mg / ml The organic-inorganic composite solution is then added to the storage container of high-voltage electrospinning, and the spinning distance is set to be 12 cm. Under the spinning voltage of 15kV, high-voltage electrospinning is carried out at a speed of 0.8ml / h until Stop electrospinning when the thickness of the fiber film reaches 150 microns;

[0091] 2) Add the electrospinning solution containing 8% polycaprolactone into the storage container of the high-voltage electrospinning equipment in the above step 1), set the spinning distance to 14 cm, and under the spinning v...

Embodiment 3

[0094] 1) Add zinc and phosphorus co-doped feldspar powder with a particle size of 0.80 to 4.25 microns (the content of zinc and phosphorus is 1.2% and 3.4% respectively) into a mixture containing 6% poly L-lactide-caprolactone (PLCL) solution and fully stirred, the mass ratio of inorganic particles to PLCL is 1:5, prepared into an organic-inorganic composite solution with a ceramic powder concentration of 40mg / ml, and then added to the high-voltage electrospinning storage material In the container, the spinning distance is set to be 14 cm, and the high-voltage electrospinning is carried out at a speed of 0.6 ml / h at a spinning voltage of 12 kV, until the PLCL fiber film thickness reaches 250 microns, and the electrospinning is stopped;

[0095] 2) Add the electrospinning solution containing 6% polycaprolactone into the storage container of the high-voltage electrospinning equipment in the above step 1), set the spinning distance to 12 cm, and under the spinning voltage of 14 k...

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Abstract

The invention discloses a gradient material for promoting cartilage calcification layer repair and a preparation method. The gradient material is composed of a superfine fiber microporous membrane, an organic fiber microporous membrane and an organic-inorganic composite fiber microporous membrane, wherein the upper surface and the lower surface of the superfine fiber microporous membrane are covered with the organic fiber microporous membrane and the organic-inorganic composite fiber microporous membrane respectively. The upper layermembrane contains components that promote cartilage healing, an inorganic component in the lower layer membrane is composed of multifunctional inorganic particles which can inhibit inflammation, prevent and control infection and promote regeneration and repair of a cartilage calcification layer, and the gradient material is prepared through a three-step electrostatic spinning technology. The method is convenient to operate, and the gradient material has a remarkable promoting effect on various articular cartilage injury problems, especially on regeneration, repair and reconstruction of a calcified layer, can also promote healing of subchondral bones and cartilage tissues, is adjustable in degradation rate of gradient materials, and has a good regulating effect on various joint lesion inflammations.

Description

technical field [0001] The invention belongs to the field of biomedical implant materials and relates to an implant gradient material and a preparation method, in particular to a gradient functional material and a preparation method for promoting the repair and reconstruction of cartilage calcification layer. Background technique [0002] The joints between the bones in the human body perform the function of coordinating the movement of the limbs. However, arthritic lesions in the joints, various bone-cartilage injuries, joint fractures and other problems will lead to cartilage damage in the joints, causing persistent or seasonal pain in patients, and it is difficult for patients to pay attention to articular cartilage damage caused by joint lesions in the early stage. It often involves the cartilage to the underlying bone, so if this kind of problem is not dealt with in time, the basic motor function of the injured joint will be lost, especially the joint injury of the lowe...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/12A61L27/16A61L27/18A61L27/20A61L27/22A61L27/24A61L27/54D04H1/413D04H1/4382D04H1/728
CPCA61L27/10A61L27/12A61L27/20A61L27/24A61L27/227A61L27/222A61L27/18A61L27/16A61L27/54D04H1/728D04H1/43838D04H1/413A61L2430/24A61L2300/232A61L2300/252A61L2300/404A61L2300/412
Inventor 苟中入刘梦涛杨贤燕钟成高长有毛铮伟沈淼达赵腾飞谢利军金日龙
Owner ZHEJIANG UNIV
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