Gradient material for promoting cartilage calcification layer repair and preparation method

Abstract

The invention discloses a gradient material for promoting cartilage calcification layer repair and a preparation method. The gradient material is composed of a superfine fiber microporous membrane, an organic fiber microporous membrane and an organic-inorganic composite fiber microporous membrane, wherein the upper surface and the lower surface of the superfine fiber microporous membrane are covered with the organic fiber microporous membrane and the organic-inorganic composite fiber microporous membrane respectively. The upper layermembrane contains components that promote cartilage healing, an inorganic component in the lower layer membrane is composed of multifunctional inorganic particles which can inhibit inflammation, prevent and control infection and promote regeneration and repair of a cartilage calcification layer, and the gradient material is prepared through a three-step electrostatic spinning technology. The method is convenient to operate, and the gradient material has a remarkable promoting effect on various articular cartilage injury problems, especially on regeneration, repair and reconstruction of a calcified layer, can also promote healing of subchondral bones and cartilage tissues, is adjustable in degradation rate of gradient materials, and has a good regulating effect on various joint lesion inflammations.

Description

technical field

[0001] The invention belongs to the field of biomedical implant materials and relates to an implant gradient material and a preparation method, in particular to a gradient functional material and a preparation method for promoting the repair and reconstruction of cartilage calcification layer. Background technique

[0002] The joints between the bones in the human body perform the function of coordinating the movement of the limbs. However, arthritic lesions in the joints, various bone-cartilage injuries, joint fractures and other problems will lead to cartilage damage in the joints, causing persistent or seasonal pain in patients, and it is difficult for patients to pay attention to articular cartilage damage caused by joint lesions in the early stage. It often involves the cartilage to the underlying bone, so if this kind of problem is not dealt with in time, the basic motor function of the injured joint will be lost, especially the joint injury of the lowe...

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