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Hydroxyapatite coating based on polyether-ether-ketone and preparation method thereof

A technology of hydroxyapatite and polyether ether ketone, applied in coatings, pharmaceutical formulations, prostheses, etc., can solve the problem of hydroxyapatite crystal morphology and size control without significant progress, hydroxyapatite coating The preparation method has not been reported, and the coated bone tissue is insufficiently bonded. It has good application prospects, avoids implantation stress shielding, and has the effect of low price.

Active Publication Date: 2021-11-12
BAOJI UNIV OF ARTS & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because PEEK itself does not have biological activity, it cannot form osseointegration with bone tissue, which limits its further promotion and application in the field of hard tissue repair and replacement to a certain extent.
Therefore, relevant researchers proposed the idea of ​​preparing a hydroxyapatite (HA) coating with good compatibility with bone tissue on the surface of PEEK, and successively used cold spraying, aerosol deposition, plasma spraying, spin coating and other methods to carry out some HA coatings. However, due to the limitations of the preparation process and various reasons, so far, there has been no significant progress in the control of the morphology and size of hydroxyapatite crystals, and most of the obtained coatings have insufficient adhesion to bone tissue, Low bonding strength, poor application effect, etc., have not been widely used
[0004] In general, although relevant scholars and research institutions have carried out some research on polyether ether ketone as an implant and the preparation of hydroxyapatite coating on its surface, and achieved certain research results, based on PEEK, using hydrothermal method The preparation method of hydroxyapatite coating with nanorod structure and good bonding strength has not been reported

Method used

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  • Hydroxyapatite coating based on polyether-ether-ketone and preparation method thereof
  • Hydroxyapatite coating based on polyether-ether-ketone and preparation method thereof

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preparation example Construction

[0031] A method for preparing a polyether ether ketone-based hydroxyapatite coating provided in an embodiment of the present invention includes the following steps:

[0032] 1) Base material preparation:

[0033] According to the mass ratio (12~10): 1, polyetheretherketone powder and Ca(OH) 2 Powder mixing, ball milling, heat treatment after tablet molding, the temperature is 280-300°C, the holding time is 2h, and polyether ether ketone and Ca(OH) 2 Mixed composite substrate materials;

[0034] 2) Pretreatment of composite substrate materials:

[0035] The composite base material was polished and polished with 2500# and 5000# sandpaper in sequence, and then placed in acetone, alcohol, deionized water and alcohol solution for ultrasonic cleaning for 10-20 minutes respectively to remove surface dirt, and then air-dried naturally to obtain a composite base;

[0036] 3) Preparation of hydrothermal solution: at room temperature, sodium glycerophosphate C with a concentration of ...

Embodiment 1

[0042] 1) Mix polyetheretherketone PEEK powder with Ca(OH) 2 The powder is mixed at a ratio of 10:1, ball milled, pressed into tablets, and heat treated at 300°C for 2 hours to obtain a composite substrate;

[0043] 2) Grind and polish the composite substrate with 2500#, 5000# sandpaper in sequence, and then place it in acetone, alcohol, deionized water and alcohol solution for ultrasonic cleaning for 10 minutes respectively;

[0044] 3) Add 0.2mol / L of C 3 h 7 Na 2 o 6 P, 2mol / L of C 10 h 12 CaN 2 Na 2 o 8 Dissolve in deionized water, add 0.02mol / L NaOH to adjust the pH value to 7, stir until the hydrothermal solution is transparent and set aside;

[0045] 4) Put the prepared hydrothermal solution and the composite substrate into the reaction kettle, keep it at 170°C for 15 hours, and complete the hydrothermal deposition;

[0046] 5) Take out the sample, rinse it with water, keep it in an oven at 70°C for 20 minutes, and obtain the mixture in PEEK and Ca(OH) 2 Hydr...

Embodiment 2

[0049] Polyetheretherketone PEEK powder and Ca(OH) 2 The powder is mixed at a ratio of 10:1, ball milled, and tabletted, then heat-treated at 280°C for 2 hours to obtain a composite substrate;

[0050] 2) Grind and polish the composite substrate with 2500#, 5000# sandpaper in turn, and then place it in acetone, alcohol, deionized water and alcohol solution for ultrasonic cleaning for 20 minutes respectively;

[0051] 3) Add 0.2mol / L of C 3 h 7 Na 2 o 6 P, 2mol / L of C 10 h 12 CaN 2 Na 2 o 8 Dissolve in deionized water, add 0.02mol / L NaOH to adjust the pH value to 6, stir until the hydrothermal solution is transparent and set aside;

[0052] 4) Put the prepared hydrothermal solution and the composite substrate into the reaction kettle, keep it at 180°C for 5 hours, and complete the hydrothermal deposition;

[0053] 5) Take out the sample, rinse it with water, keep it in an oven at 60°C for 30 minutes, and obtain the mixture in PEEK and Ca(OH) 2 Hydroxyapatite coating ...

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Abstract

The present invention discloses a hydroxyapatite coating based on polyether-ether-ketone and a preparation method thereof. The preparation method comprises the following steps: mixing polyether-ether-ketone powder and Ca(OH)2 powder, carrying out tabletting molding, and carrying out heat treatment, so as to obtain a composite substrate material; pretreating a composite substrate material; placing a substrate material in the hydrothermal solution, and heating to complete hydrothermal deposition; and washing a hydrothermal deposition sample, drying, and preserving heat to obtain the hydroxyapatite coating on the surface of the PEEK and Ca(OH)2 composite material substrate. The coating prepared by adopting the method is of a dense nano columnar structure, is firmly combined with a matrix, can effectively solve the problem of biological inertia on the surface of PEEK, can be well attached to the surface of bone tissue, remarkably promotes the osteogenesis function of cells, and is beneficial to implantation and use of a substrate material; and the coating is suitable for industrial large-scale production and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical material apatite preparation, and relates to a method for preparing a surface coating, in particular to a method for preparing a polyether ether ketone-based hydroxyapatite coating. Background technique [0002] Materials such as stainless steel, titanium, and titanium alloys have been widely used in the field of medical hard tissue repair and replacement due to their high mechanical strength, good biocompatibility, and fatigue resistance. However, due to the elasticity of these traditional metal implant materials The modulus is much higher than the elastic modulus of medical bone tissue. In practical application, it is easy to cause stress stimulation to the bone tissue around the implant, and then the bone tissue around the implant is partially absorbed and its strength is reduced, which is the so-called The "stress shielding" effect, which leads to loosening of the implant, seriously affects...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/18A61L27/02A61L27/50
CPCA61L27/32A61L27/18A61L27/025A61L27/50A61L2430/02A61L2400/12A61L2400/18A61L2420/02C08L61/16
Inventor 周建宏马语唯陈雄刚
Owner BAOJI UNIV OF ARTS & SCI
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