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Application of bioactive composite material in periodontal bone defect repair and/or periodontal bone regeneration

A technology of bioactive and composite materials, which is applied in the field of application of bioactive composite materials in periodontal bone defect repair and/or periodontal bone regeneration, which can solve the problems of complex surgery, slow degradation, easy to cause inflammation, etc., and achieve simplification The operation steps and preparation process are simple, and the effect of shortening the operation time

Active Publication Date: 2021-11-23
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Collagen membranes are very expensive, and the burden on patients is heavy
In addition to the above-mentioned collagen, polylactic acid (PLA) or poly(lactic-co-glycolic acid) (PLGA) can also be used as GBR membrane materials, but they degrade slowly in the body and the degradation products are acidic, easily causing inflammation, and the overall effect is not as good as that of collagen membranes
In addition, the use of barrier membrane alone does not promote the repair of periodontal bone defects, and usually requires the use of bone fillers, which makes the operation more complicated and the cost is further increased

Method used

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  • Application of bioactive composite material in periodontal bone defect repair and/or periodontal bone regeneration
  • Application of bioactive composite material in periodontal bone defect repair and/or periodontal bone regeneration
  • Application of bioactive composite material in periodontal bone defect repair and/or periodontal bone regeneration

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preparation example Construction

[0043] The preparation method of the present invention will be further described in detail in conjunction with specific examples below. It should be understood that the following examples are only for illustrating and explaining the present invention, and should not be construed as limiting the protection scope of the present invention. All technologies realized based on the above contents of the present invention are covered within the scope of protection intended by the present invention.

[0044] The experimental methods used in the following examples are conventional methods unless otherwise specified; the reagents and materials used in the following examples can be obtained from commercial sources unless otherwise specified.

[0045] Biological testing methods are as follows:

[0046] 1. Cell culture

[0047] To evaluate the effect of bioactive nanoparticles on osteoblasts and fibroblasts, we chose mouse osteoblast cell line MC3T3-El, mouse fibroblast cell line L929 and...

preparation example 1

[0060] Preparation Example 1: Preparation of Bioactive Nanoparticles and Biological Test Results

[0061] 0.2 mL of 3-methacryloxypropyltrimethoxysilane and 0.6 mL of isoamyl acetate were added to 40 mL of pure water. The pH of the solution was adjusted to 10. After ultrasonication for 15 minutes, nitrogen gas was introduced for 20 minutes to remove the oxygen in the reaction bottle. The mixture system was heated to 70° C., 10 mg of potassium persulfate was added, and the polymerization reaction was continued for 20 hours to terminate the reaction. Then the centrifuge was centrifuged at a speed of 10,000 rpm for 15 minutes to collect a white precipitate, which was washed three times with ethanol. The nanoparticles are dispersed in water to form a colloidal solution. 300mL saturated Ca(OH) 2 The solution is added to the colloidal solution of the above particles, Ca(OH) 2 The molar ratio to nanoparticles is 50:1. After the system was stirred at 25° C. for 24 hours, the preci...

preparation example 2

[0064] Preparation Example 2: Preparation of Bioactive Nanoparticles

[0065] At room temperature, 4.48 mL of silica dispersion (Ludox TM40) with a solid content of 40% and 4 mL of 3-methacryloxypropyltrimethoxysilane were added to 150 mL of pure water, and stirred for 24 hours to form an emulsion. Nitrogen gas was introduced into the emulsion, and after deoxygenation for 30 minutes, the temperature of the system was raised to 70° C., and 25 mg of potassium persulfate was added to initiate polymerization, and the polymerization reaction continued for 24 hours. The emulsion was centrifuged at 11,000 rpm for 15 minutes to collect a white precipitate, which was washed three times with ethanol. 100 mL of saturated CaCl 2 solution was added to the colloidal solution of the above particles, CaCl 2 The molar ratio to nanoparticles is 100:1. After the system was stirred at 15° C. for 48 hours, the precipitate was collected by centrifugation, washed with pure water, and dried to obt...

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Abstract

The invention discloses an application of a bioactive composite material in periodontal bone defect repair and / or periodontal bone regeneration. The bioactive composite material comprises colloidal silicon dioxide bioactive nanoparticles subjected to calcium ion surface modification and a cross-linked high polymer material. In addition to promoting migration, proliferation and mineralization of osteoblasts, the bioactive composite material disclosed by the invention can also inhibit migration, adhesion and proliferation of fibroblasts and inhibit the fibroblasts from invading into defect areas of periodontal bones, is beneficial to rapid regeneration and repair of periodontal bone tissues, and avoids invasion of fibrous tissues and generation of fibrosis. Therefore, the effect of inhibiting fibroblasts from invading and entering a bone defect area without using a barrier membrane can be achieved, meanwhile, bone regeneration and bone defect repair are promoted, surgical operation can be greatly facilitated, and the surgical cost of treatment can be reduced.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to the application of a bioactive composite material in periodontal bone defect repair and / or periodontal bone regeneration. Background technique [0002] Periodontitis is a very common disease that leads to the deterioration of periodontal tissues including gums, cementum, periodontal ligament and alveolar bone. Periodontitis affects nearly 90% of people worldwide. Alveolar bone resorption is a characteristic pathological change of periodontitis. Under physiological conditions, alveolar bone resorption and regeneration are in a state of dynamic balance. Alveolar bone defects develop when there is increased bone resorption, decreased bone regeneration, or both. Traditional treatments, including tooth extraction and root planing, are effective in preventing the spread of periodontal inflammation, but cannot restore lost bone tissue. Periodontal bone transplantation...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/20A61L27/02A61L27/24A61L27/50A61L27/52A61L27/54A61L27/56
CPCA61L27/222A61L27/24A61L27/20A61L27/025A61L27/52A61L27/56A61L27/50A61L27/54A61L2430/12A61L2300/10A61L2300/412A61L2300/624C08L5/08
Inventor 邱东崔杨
Owner INST OF CHEM CHINESE ACAD OF SCI
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