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Application of a bioactive composite material in periodontal bone defect repair and/or periodontal bone regeneration

A bioactive, composite material technology, applied in the application field of bioactive composite materials in periodontal bone defect repair and/or periodontal bone regeneration, can solve the problems of complicated surgery, slow degradation, easy to cause inflammation, etc., to simplify The operation steps, the preparation process are simple, and the effect of shortening the operation time

Active Publication Date: 2022-05-27
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Collagen membranes are very expensive, and the burden on patients is heavy
In addition to the above-mentioned collagen, polylactic acid (PLA) or poly(lactic-co-glycolic acid) (PLGA) can also be used as GBR membrane materials, but they degrade slowly in the body and the degradation products are acidic, easily causing inflammation, and the overall effect is not as good as that of collagen membranes
In addition, the use of barrier membrane alone does not promote the repair of periodontal bone defects, and usually requires the use of bone fillers, which makes the operation more complicated and the cost is further increased

Method used

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  • Application of a bioactive composite material in periodontal bone defect repair and/or periodontal bone regeneration
  • Application of a bioactive composite material in periodontal bone defect repair and/or periodontal bone regeneration
  • Application of a bioactive composite material in periodontal bone defect repair and/or periodontal bone regeneration

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preparation example Construction

[0043] The preparation method of the present invention will be described in further detail below with reference to specific examples. It should be understood that the following examples are only for illustrating and explaining the present invention, and should not be construed as limiting the protection scope of the present invention. All technologies implemented based on the above content of the present invention are covered within the intended protection scope of the present invention.

[0044] The experimental methods used in the following examples are conventional methods unless otherwise specified; the reagents, materials, etc. used in the following examples can be obtained from commercial sources unless otherwise specified.

[0045] The biological test method is as follows:

[0046] 1. Cell Culture

[0047] To evaluate the effect of bioactive nanoparticles on osteoblasts and fibroblasts, we selected mouse osteoblast cell line MC3T3-El, mouse fibroblast cell line L929 a...

preparation example 1

[0060] Preparation Example 1: Preparation of Bioactive Nanoparticles and Biological Test Results

[0061] 0.2 mL of 3-methacryloyloxypropyltrimethoxysilane and 0.6 mL of isoamyl acetate were added to 40 mL of pure water. The pH of the solution was adjusted to 10. After sonication for 15 minutes, nitrogen was bubbled for 20 minutes to remove oxygen in the reaction vial. The mixture system was heated to 70° C., 10 mg of potassium persulfate was added, and the polymerization was continued for 20 hours to terminate the reaction. The centrifuge was then centrifuged at 10,000 rpm for 15 minutes to collect white precipitates, which were washed three times with ethanol. The nanoparticles are dispersed in water to form a colloidal solution. 300mL saturated Ca(OH) 2 The solution is added to the colloidal solution of the above particles, Ca(OH) 2 The molar ratio to nanoparticles is 50:1. After the system was stirred at 25°C for 24 hours, the precipitate was collected by centrifugatio...

preparation example 2

[0064] Preparation Example 2: Preparation of Bioactive Nanoparticles

[0065] 4.48 mL of silica dispersion (Ludox TM40) with a solid content of 40% and 4 mL of 3-methacryloyloxypropyltrimethoxysilane were added to 150 mL of pure water at room temperature and stirred for 24 hours to form an emulsion. Nitrogen was introduced into the emulsion, and after 30 minutes of deoxygenation, the temperature of the system was raised to 70° C., 25 mg of potassium persulfate was added to initiate polymerization, and the polymerization reaction continued for 24 hours. The emulsion was centrifuged at 11,000 rpm for 15 minutes to collect a white precipitate, which was washed three times with ethanol. 100mL saturated CaCl 2 The solution was added to the colloidal solution of the above particles, CaCl 2 The molar ratio to nanoparticles is 100:1. After the system was stirred at 15°C for 48 hours, the precipitate was collected by centrifugation, washed with pure water, and dried to obtain bioact...

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Abstract

The invention discloses the application of a bioactive composite material in periodontal bone defect repair and / or periodontal bone regeneration. The bioactive composite material includes colloidal silicon dioxide bioactive nanoparticles modified on the surface of calcium ions and cross-linked polymer materials. In addition to promoting the migration, proliferation and mineralization of osteoblasts, the bioactive composite material of the present invention can also inhibit the migration, adhesion and proliferation of fibroblasts, and inhibit the invasion of fibroblasts into the defect area of ​​periodontal bone, which is beneficial to Rapid regeneration and repair of periodontal bone tissue, avoiding the invasion of fibrous tissue and the generation of fibrosis. Therefore, the effect of inhibiting the invasion of fibroblasts into the bone defect area without using a barrier membrane can be obtained, and at the same time, the regeneration of bone and the repair of bone defect can be promoted, which can greatly facilitate operation and reduce the operation cost of treatment.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to the application of a bioactive composite material in periodontal bone defect repair and / or periodontal bone regeneration. Background technique [0002] Periodontitis is a very common disease that causes the deterioration of periodontal tissues including the gums, cementum, periodontal ligaments and alveolar bone. Nearly 90% of people worldwide are affected by periodontitis. Alveolar bone resorption is a characteristic pathological change of periodontitis. Under physiological conditions, alveolar bone resorption and regeneration are in a state of dynamic equilibrium. Alveolar bone defects occur when bone resorption increases or bone regeneration decreases, or both. Traditional treatments, including tooth extraction and root planing, are effective in preventing the spread of periodontal inflammation but cannot restore lost bone tissue. Periodontal bone grafting i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/22A61L27/20A61L27/02A61L27/24A61L27/50A61L27/52A61L27/54A61L27/56
CPCA61L27/222A61L27/24A61L27/20A61L27/025A61L27/52A61L27/56A61L27/50A61L27/54A61L2430/12A61L2300/10A61L2300/412A61L2300/624C08L5/08
Inventor 邱东崔杨
Owner INST OF CHEM CHINESE ACAD OF SCI
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