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Oxygen-deficient iron molybdenum oxide flower-like nanoparticles for diagnosis and treatment integration as well as preparation method and application of oxygen-deficient iron molybdenum oxide flower-like nanoparticles

An oxide and oxygen deficiency technology, which is applied in the field of nano-drug presentation systems and contrast agents, can solve the problems of short infrared absorption wavelength of nanoparticles and poor photothermal treatment effect, and achieve the effect of accurate monitoring of prognosis

Pending Publication Date: 2022-03-29
THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention intends to provide an oxygen-deficient iron-molybdenum oxide flower-shaped nanoparticle for the integration of diagnosis and treatment, so as to solve the technical problem that the infrared absorption wavelength of the nanoparticle in the prior art is too short, resulting in poor photothermal treatment effect

Method used

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  • Oxygen-deficient iron molybdenum oxide flower-like nanoparticles for diagnosis and treatment integration as well as preparation method and application of oxygen-deficient iron molybdenum oxide flower-like nanoparticles
  • Oxygen-deficient iron molybdenum oxide flower-like nanoparticles for diagnosis and treatment integration as well as preparation method and application of oxygen-deficient iron molybdenum oxide flower-like nanoparticles
  • Oxygen-deficient iron molybdenum oxide flower-like nanoparticles for diagnosis and treatment integration as well as preparation method and application of oxygen-deficient iron molybdenum oxide flower-like nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: Preparation of nanoparticles

[0046] (1) Finding mixture of dibenzyl ether, 1,2-dodiol diol and hexatide mo molybdenum, wherein under a three-necked flask placed in severe magnetic stirring, nitrogen protection is heated. The ratio of dibenzyl ether, 1,2-dikartyne glycol and hexatonic molybdenum is 20 ml: 1.5 g: 1 mmol.

[0047] (2) When the system temperature is heated to 120 ° C, oleic acid and oleine (oleic acid, olelamine, and molin ether) are added to the mixed liquid II, and mixed liquid II, then subsequent Continue to heat the temperature rise.

[0048] (3) When the mixture II temperature was raised to 260 ° C, then acetylacetonate ferrite was added to the mixture II, and the reaction was continued for 30 minutes to obtain a mixture III. Among them, the molar ratio of hexaparbonyl molybdenum with acetylacetonate is 1: 1.

[0049] The entire process of step (1) - (3) requires isolation of air and is carried out under the protection of nitrogen.

[0050] (4...

Embodiment 2

[0059] Example 2: Chemical kinetics of nanoparticles

[0060] Nano-granular chemical dynamic therapeutic performance was detected as an indicator using MB (methylene blue). MB with FMO-PEGNPS and H 2 O 2 Added in PBS (pH = 6.0) buffer (500 μg / ml Fmo-PEG NPS, MB 10 μg / ml, H) was contained in PBS. 2 O 2 10mm). After the reaction, the peak variation of MB at 665 nm was observed using an ultraviolet spectrometer. · OH can be specifically reacted with the reagent MB to reduce its 665 nm. Such as Figure 16 The MB is also FMO-PEG NPS and H in an acidic environment. 2 O 2 After incubation, MB was decreased at a characteristic peak of 665 nm. Certificate rich in h 2 O 2 Under acidic conditions, FMO-PEG NPS can effectively produce · OH, confirming excellent chemical dynamic performance of nanomelet.

Embodiment 3

[0061] Example 3: Total therapeutic performance of nanoparticles

[0062] The photodynamic performance of nanoparticles was detected by DPBF (diphenylisine furan). The FMO-PEG NPS was mixed with DPBF in PBS buffer (pH = 6.0) (1 ml 500 μg / mL FMO-PEG NPS and 15 μl of 1 mg / ml of DPBF mixed in 1 ml of PBS system), then laser at 1060 nm Different times under irradiation (0, 5, 10, 15, 20, 25, and 30 min). The absorbance change was observed at 418 nm using an ultraviolet lightometer observation system at 418 nm. 1 O 2 It is possible to specifically react with the reagent DPBF to reduce the characteristic peak at 418 nm. Such as Figure 17 As shown, the system is at 1060 nm (0.5W / cm) 2 Laser irradiation at different times, DPBF is gradually declined at a characteristic peak of 418 nm, which proves that the irradiation time is extended, and the FMO-PEG NPS system 1 O 2 Yield increased, the irradiation time was positively correlated, confirming excellent photodynamic performance of na...

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Abstract

The invention relates to the technical field of nano-drug presentation systems and contrast agents, in particular to oxygen-deficient iron molybdenum oxide flower-shaped nanoparticles for diagnosis and treatment integration and a preparation method and application thereof. The oxygen-deficient iron-molybdenum oxide contains iron elements with trivalent and divalent valence states and molybdenum elements with hexavalent and pentavalent valence states, and is prepared by the following method: preparing a mixed solution I containing dibenzyl ether, 1, 2-dodecynediol and hexa-carbon-based molybdenum; heating the mixed solution I, and adding oleic acid and oleylamine to obtain a mixed solution II; heating the mixed solution II, adding ferrous acetylacetonate, and reacting to obtain a mixed solution III, so as to obtain the oxygen-deficient iron molybdenum oxide flower-like nanoparticles. The oxygen-deficient iron molybdenum oxide flower-like nanoparticles can effectively resist tumors through the synergistic treatment effect of photothermal / photodynamic / chemical dynamic therapy, can serve as an effective contrast agent for magnetic resonance and photoacoustic imaging, can accurately guide treatment and monitor prognosis, and has a wide application prospect.

Description

Technical field [0001] The present invention relates to a nano-drug presentation system and a contrast technique, and more particularly to oxygen lack of iron-molybdenum oxide flowers for diagnosis and treatment and preparation methods and applications thereof. Background technique [0002] Single tumor treatment, the efficacy is difficult to achieve the ideal effect, how to effectively combine a number of treatments, and become a research hotspot. At present, some studies have tried to combine a variety of tumor treatment methods to prepare new nano-drug presented systems. Jing Bai(A Facile Ion-Doping Strategy to Regulate Tumor Microenvironmentsfor Enhanced Multimodal Tumor Theranostics,Jing Bai,Journal of the AmericanChemical Society,2017)报道了一种光热治疗(PTT)、光动力治疗(PDT)和化学动力治疗(CDT) combined nano-drug presented system. The nano-drug presentation system integrates iron ions to form a core on a polymer polymer, and loading methylene blue and dihydroenilin artemisinin. However, the above...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/22C01G39/02C01G49/04C01G49/06
CPCA61K49/0002A61K49/126A61K49/225C01G49/06C01G49/04C01G39/02C01P2004/64C01P2006/62C01P2004/80C01P2004/04C01P2002/72
Inventor 向覃言秋王志刚罗远利杨超
Owner THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY
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