Seaweed extract capable of effectively relieving skin sunburn and preparation method and application thereof

A seaweed extract and skin technology, which is applied in the field of seaweed extract and its preparation, can solve the problems of allergic contact dermatitis, limit the wide use and the like, and achieve the effects of reducing inflammation, reducing pollutants, and reducing skin sunburn

Active Publication Date: 2022-04-15
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sunscreen agents in sunscreen cosmetics mostly contain benzene rings and unsaturated side chains, and adverse reactions such as allergic contact dermatitis sometimes occur after ultraviolet radiation, which limits their wide use to a certain extent.
The drugs that can be used clinically are mostly used to prevent and treat skin photoaging, such as retinoic acid drugs, isotretinoin, tazarotene, retinol, antioxidants (vitamin C, vitamin E, β -carotene, coenzyme Q10, superoxide dismutase SOD, etc.), depigmentation agents (hydroquinone, arbutin, etc.), exfoliating agents (α-hydroxy acids, β-hydroxy acids, etc.), cytokines (epidermal growth factor EGF, fibroblast growth factor FGF, platelet-derived growth factor PDGF, etc.), natural biological extracts (epigallocatechin gallate EGCG, anthocyanins, etc.), trace elements (selenium), sex hormones, etc., for skin tanning There are relatively few preparations and drugs for injury protection

Method used

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  • Seaweed extract capable of effectively relieving skin sunburn and preparation method and application thereof
  • Seaweed extract capable of effectively relieving skin sunburn and preparation method and application thereof
  • Seaweed extract capable of effectively relieving skin sunburn and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Take edible hijiki sun-dried algae that meet the standards for use of relevant seafood in my country, wash with distilled water for 3 to 4 times, dry and pulverize to obtain dry powder. Weigh 200g of dry powder, add 10L of distilled water, and cook in boiling water at 100°C for 0.5h. After cooling the extract, centrifuge at 3000g for 15min. The centrifuged supernatant was suction-filtered (filtered with qualitative filter paper), and the filtrate was filtered through an ultrafiltration membrane with a molecular weight cut-off of 5kDa, and the ultrafiltration retentate was collected, concentrated, and freeze-dried to obtain seaweed extract.

[0063] Studies have found that the seaweed extract prepared in this example has good biocompatibility, no sensitization, does not cause skin photosensitivity, can significantly improve cell apoptosis and necrosis caused by ultraviolet radiation, and reduce dermal inflammation after ultraviolet radiation. Exudation and degradation o...

Embodiment 2

[0065] Weigh 200 g of edible fresh hijiki that meets the standards for the use of relevant seafood in my country, wash it with deionized water for 3 to 4 times, crush it, add 4 L of deionized water, and bathe in boiling water at 100°C for 4 hours. After cooling, centrifuge at 8000g for 12min. The centrifuged supernatant was then sequentially filtered through an ultrafiltration membrane with a pore size of 0.45 μm and a molecular weight cut-off of 3 kDa. The 3kDa~0.45μm retentate was collected, concentrated and freeze-dried to obtain seaweed extract.

[0066] Studies have found that the seaweed extract prepared in this example has good biocompatibility, no sensitization, does not cause skin photosensitivity, can significantly improve cell apoptosis and necrosis caused by ultraviolet irradiation, and reduce dermal inflammatory exudation after ultraviolet irradiation. It can degrade collagen and elastic fibers, reduce erythema, inflammation, exudate, desquamation, scab and other...

Embodiment 3

[0068] Weigh 200g of edible hijiki sun-dried algae that meet the relevant standards for the use of seafood in my country, soak in distilled water for 30 minutes, wash 3 to 4 times, and soak in distilled water for 30 minutes again. Crush the hijiki algae, add 5L of distilled water, and cook in boiling water at 100°C for 1 hour. After the extract was cooled, it was centrifuged at 10000g for 10min. The centrifuged supernatant was suction-filtered (filtered with qualitative filter paper), and the filtrate was filtered through an ultrafiltration membrane with a molecular weight cut-off of 5 kDa. The ultrafiltration retentate was collected, concentrated and freeze-dried to obtain seaweed extract.

[0069] Studies have found that the seaweed extract prepared in this example has good biocompatibility, no sensitization, does not cause skin photosensitivity, can significantly improve cell apoptosis and necrosis caused by ultraviolet irradiation, and reduce dermal inflammatory exudation...

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Abstract

The invention discloses a seaweed extract capable of effectively relieving skin sunburn as well as a preparation method and application of the seaweed extract. The preparation method comprises the following steps: weighing a certain amount of seaweed, adding 20-50 times of volume of water and boiling water, leaching for 0.5-4 hours, cooling the leaching solution, centrifuging for 10-15 minutes by 3000g-10000g, and sequentially carrying out suction filtration, ultrafiltration, ultrafiltration trapped fluid collection, concentration and freeze-drying on the centrifuged supernate to obtain the seaweed extract. By adopting the preparation method disclosed by the invention, components which do not remarkably improve the activity of cells irradiated by ultraviolet rays can be removed, and active components which can effectively relieve skin sunburn in the seaweed extract are highly enriched, so that the physiological efficacy of the seaweed extract is improved, and the dosage of the seaweed extract is greatly reduced. The seaweed extract is high in safety, cell apoptosis and necrosis caused by ultraviolet irradiation can be remarkably reduced, true dermatitis exudation and elastic fiber degradation are reduced, and skin ultraviolet sunburn is effectively relieved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a seaweed extract which can effectively relieve skin sunburn, its preparation method and application. Background technique [0002] With the destruction of the ozone layer, the skin is exposed to excessive ultraviolet rays for a long time, leading to an increase in the incidence of actinic skin diseases, basal cell carcinoma, and squamous cell carcinoma. After the skin is over-irradiated by ultraviolet rays in the sun, local acute phototoxic dermatitis often occurs, and it is also easy to trigger light eruption multiforme, herpes simplex, solar urticaria, erythema multiforme, porphyria cutanea tarda, lupus erythematosus , Vitiligo, telangiectasia and sunstroke. Therefore, it is very important to find various measures to effectively reduce skin damage and canceration caused by ultraviolet radiation. [0003] External application of sunscreen cosmetics can effectively prevent...

Claims

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Application Information

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IPC IPC(8): A61K36/03A61P17/16A61K8/9711A61Q17/04A61Q19/00A61L15/40A61L26/00
Inventor 陈华孙恢礼潘剑宇蔡冰娜万鹏陈得科
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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