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Bowel-relaxing oral liquid and preparation method thereof

An oral liquid, weight percentage technology, applied in the field of medicine, can solve the problems of easy oxidation, inconvenience in use, difficulty in developing liquid preparations, etc., and achieve the effects of improving safety, avoiding irritation to the intestines, and being beneficial to intestinal health.

Pending Publication Date: 2022-06-21
STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product box contains 4 sachets of medicine and a disposable container for mixing. Before use, the medicine in the bag needs to be mixed and added with water, which is very inconvenient for patients to use
However, vitamin C is a strong reducing agent and is easily oxidized, which brings great difficulties to the development of vitamin C preparations, especially the development of liquid preparations.

Method used

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  • Bowel-relaxing oral liquid and preparation method thereof
  • Bowel-relaxing oral liquid and preparation method thereof
  • Bowel-relaxing oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the preparation of laxative oral liquid

[0030] The preparation of the laxative oral liquid of Experimental Example 1-10 and Comparative Example 1-3 includes the following steps:

[0031] (1) Dissolution: According to the ratio shown in Table 1, weigh purified water and each component, and stir and dissolve at room temperature.

[0032] (2) Filling.

[0033] Table 1 Experimental example and prescription of comparative example

[0034]

[0035]

Embodiment 2

[0036] Example 2. Stability test

[0037] The ascorbic acid component is easily oxidized. In order to verify and test the stability of the oral liquid of the present invention and the ascorbic acid component, the following experiments were carried out.

[0038] 1. Detection method

[0039] Test samples: Experimental Examples 1-10, Comparative Examples 1 and 3.

[0040] Test conditions: high temperature (60℃), light (4500±500Lux).

[0041] Sampling time: 0 days, 7 days, 14 days, 28 days

[0042] Detection indicators / standards:

[0043] Solution color: Compared with the same volume of yellow No. 4 standard colorimetric solution, it should not be darker.

[0044] Determination method of ascorbic acid component content (in L-ascorbic acid): refer to the content detection method of vitamin C (L-ascorbic acid) contained in the 2020 edition of the "Chinese Pharmacopoeia", and use the iodine titration method to determine.

[0045]Ascorbic acid content standard: 90.0-110.0%.

[0...

Embodiment 3

[0054] Embodiment 3, antibacterial efficacy test

[0055] In order to detect and verify the antiseptic and bacteriostatic efficacy of the oral liquid of the present invention, the following experiments were carried out.

[0056] 1. Detection method

[0057] Test samples: Experimental Examples 1-10.

[0058] Test strains: Candida albicans, Aspergillus niger, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli.

[0059] The detection standard is detected according to the standards and methods of the 2020 edition of the Chinese Pharmacopoeia: bacteria: 14 days, the reduced lg value is >3, and the reduced lg value of 28 days is ≤0.5 compared with 14 days. Fungi: 14 days, the reduced lg value > 1, 28 days compared with 14 days, the reduced lg value ≤ 0.5.

[0060] 2. Experimental results

[0061] The antibacterial efficacy test results of the laxative oral liquids of Experimental Examples 1-10 are shown in Table 4-8. ①, ②, and ③ in the table represent the lg value ...

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Abstract

The invention discloses a bowel-relaxing oral liquid, the active components of the oral liquid comprise an ascorbic acid component, polyethylene glycol and oligosaccharide, the weight percentage of the ascorbic acid component is 0.24-2.4%, the weight percentage of the polyethylene glycol is 16-60%, and the weight percentage of the oligosaccharide is 1-8%. The oral liquid disclosed by the invention has a good bowel relaxing effect, is good in stability, does not need to be added with preservatives, and can inhibit reproduction of harmful bacteria in intestinal tracts and promote growth of beneficial bacteria; the oral liquid can be directly taken by patients without being prepared; the oral liquid is simple in preparation process and cost-saving.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a laxative oral liquid and a preparation method thereof. Background technique [0002] Constipation is a relatively common digestive system disease, and normal people defecate 1-2 times a day or once every 1-2 days. The symptoms of constipation patients are mostly fecal induration, difficulty in defecation, laborious defecation, inexhaustible defecation, induration and small amount of feces, and reduction in the frequency of defecation (≤3 times per week), which brings great trouble to the patient's life. [0003] Polyethylene glycol (Polyethylene Glycol, PEG) is a long-chain polymer obtained by the polymerization of ethylene oxide, which has the effect of laxative and bowel cleansing. After polyethylene glycol is orally administered into the human body, it binds and fixes the water in the intestinal tract through hydrogen bonding, increases the water content of the feces, increases the ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/77A61K47/02A61K47/10A61K47/26A61P1/10A61K31/375A61K31/702A61K31/715
CPCA61K31/375A61K31/77A61K31/702A61K31/715A61K9/0095A61K47/02A61K47/26A61K47/10A61P1/10A61K2300/00
Inventor 尹秀菊谭剑平
Owner STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD
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