Zwitter-ion hydrogel coating for anticoagulation and preparation method of zwitter-ion hydrogel coating
A zwitterion and hydrogel technology, which is applied in anticoagulation treatment, coating, packaging food, etc., can solve the problems of cumbersome coating curing process, low interface bonding strength, and insufficient long-term stability, and achieve long-lasting anticoagulation Blood effect, enhanced mechanical properties, excellent superhydrophilic effect
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Embodiment 1
[0054] (1) 1.5g of 3-[3-(acrylamidopropyl)dimethylamino]-propionate (CBAA), 75mg of N,N-methylenebisacrylamide and 10.5mg of ammonium persulfate were weighed and dissolved in 10 mL of deionized water to prepare the aqueous phase. Then, 0.87 g of Tween-80 and 5.28 g of Span-80 were dissolved in 615 mL of n-hexane to prepare an oil phase. The aqueous phase was slowly added to the oil phase and treated by ultrasonic cell disintegrator in an ice bath to give a pale blue emulsion. The resulting emulsion was transferred to a three-necked flask, followed by heating to 80° C. and carrying out a polymerization reaction in a nitrogen atmosphere. After 2 hours of reaction, the reaction solution was cooled to room temperature, the microgel suspension was centrifuged at high speed to obtain the lower layer precipitate, and finally, the purified polycarboxybetaine microgel was obtained by dialysis and freeze-drying. like figure 1 As shown, the particle size and morphology of the prepared...
Embodiment 2
[0060] (1) Weigh any mass of SBMA monomer, 2-hydroxy-2-methyl-1-phenyl-1-propanone and N,N-methylenebisacrylamide into 20 mL of aqueous solution. It was then dissolved by magnetic stirring in the dark to prepare a hydrogel pre-solution.
[0061] (2) Using polyvinyl chloride as the modified substrate, the polyvinyl chloride plate was treated by oxygen plasma for 3 minutes, and then immersed in 100 mL of acetone solution containing 10 wt % benzophenone for 10 minutes. The treated polyvinyl chloride plates were washed sequentially with ethanol and water and dried under vacuum. The pre-gel solution prepared in step (1) was transferred to a polyvinyl chloride plate, then exposed to UV light for 12 hours under nitrogen atmosphere, and then rinsed with deionized water to remove unreacted reagents to obtain no microagglomeration. A traditional zwitterionic hydrogel coating for glue.
[0062] Figure 4The results of the anti-fibrinogen, L929 cell and platelet adhesion tests of the m...
Embodiment 3
[0066] (1) 1.5g of 3-[3-(acrylamidopropyl)dimethylamino]-propionate (CBAA), 75mg of N,N-methylenebisacrylamide and 10.5mg of ammonium persulfate were weighed and dissolved in 10 mL of deionized water to prepare the aqueous phase. Then, 0.87 g of Tween-80 and 5.28 g of Span-80 were dissolved in 615 mL of n-hexane to prepare an oil phase. The aqueous phase was slowly added to the oil phase and treated by ultrasonic cell disintegrator in an ice bath to give a pale blue emulsion. The resulting emulsion was transferred to a three-necked flask, followed by heating to 80° C. and carrying out a polymerization reaction in a nitrogen atmosphere. After 2 hours of reaction, the reaction solution was cooled to room temperature, the microgel suspension was centrifuged at high speed to obtain the lower layer precipitate, and finally, the purified polycarboxybetaine microgel was obtained by dialysis and freeze-drying.
[0067] (2) 0.5 g of polycarboxybetaine microgel prepared in step (1), 1...
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