Water-insoluble cyclodextrin polymer-based antibacterial microsphere material and preparation method thereof

A cyclodextrin polymer, water-insoluble technology, applied in the field of antibacterial materials, can solve problems such as difficulty in recycling, limited application fields, and β-CD does not have antibacterial properties, and achieve low cost, high product quality, and antibacterial properties Good results

Pending Publication Date: 2022-08-05
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1) β-CD has good water solubility and is difficult to recycle and reuse in water pollution control;
[0005] 2) β-CD itself does not have antibacterial properties, and its application fields are limited

Method used

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  • Water-insoluble cyclodextrin polymer-based antibacterial microsphere material and preparation method thereof
  • Water-insoluble cyclodextrin polymer-based antibacterial microsphere material and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0031] A preparation method of a water-insoluble cyclodextrin polymer-based antibacterial microsphere material, comprising the following steps:

[0032] 1) Use a graduated cylinder to measure pure water, glacial acetic acid and tetrabutyl titanate respectively, pour the pure water and glacial acetic acid into a beaker in turn and place them on a magnetic stirrer, stir at room temperature for 1-3 hours, and use a plastic tip dropper to slowly Add tetrabutyl titanate dropwise, continue stirring at room temperature for 6-8 hours after the titration is completed, to obtain nano-titanium dioxide sol; place the sol in a 60°C blast drying oven to dry for 12-48 hours, and use an agate mortar to obtain a solid. Grind into powdered nano-titanium dioxide;

[0033] 2) Measure sodium hydroxide, pour it into a beaker and add water to prepare a sodium hydroxide solution, add β-CD powder, stir at 500rpm for 8-16h in a 30-40°C water bath, then add epichlorohydrin and continue After stirring f...

Embodiment 1

[0037] 1) Using the sol-gel method to prepare the nano-titanium dioxide antibacterial agent, use a graduated cylinder to measure 50 parts of pure water, 10 parts of glacial acetic acid and 4 parts of tetrabutyl titanate respectively, pour the pure water and glacial acetic acid into a beaker successively and place them in the beaker. On a magnetic stirrer, stir at room temperature for 2 hours, slowly drop tetrabutyl titanate within 1 hour using a plastic tip dropper, and continue stirring at room temperature for 7 hours after the titration is completed to obtain nano-titania sol. The sol was dried in a blast drying oven at 60° C. for 24 hours, and the obtained solid was ground into powdery nano-titanium dioxide with an agate mortar.

[0038] 2) Measure 15 parts of sodium hydroxide solution, pour it into a beaker to prepare sodium hydroxide solution, add 10 parts of β-CD powder, stir in a 35°C water bath at 500 rpm for 12 hours, and then add 1 part of epichlorohydrin , after sti...

Embodiment 2

[0041] Take the titanium dioxide / β-CD polymer-based microspheres prepared in Example 1 as samples, and carry out relevant performance tests:

[0042] like figure 1 As shown, the prepared microspheres have good adsorption and degradation ability to water pollutants (take tetracycline as an example), and under the action of natural light, the tetracycline in the water can be completely adsorbed and degraded in about half an hour.

[0043] like figure 2 As shown in the figure, the prepared microspheres were loaded on the gel carrier, and the antibacterial experiments were carried out. The results showed that both Escherichia coli and Staphylococcus aureus had better killing effects under natural light or in the dark. In the figure, A: Staphylococcus aureus light treatment; B: Staphylococcus aureus light treatment; C: Escherichia coli light treatment; D: Escherichia coli light treatment; a, b, c, d indicate that the concentration of the product used is 0.1, respectively , 0.2, ...

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Abstract

The invention belongs to the technical field of antibacterial materials, and particularly relates to a water-insoluble cyclodextrin polymer-based antibacterial microsphere material and a preparation method thereof.In the preparation method, pure water or a weakly alkaline solution is adopted as a solvent, epoxy chloropropane is adopted as a cross-linking agent, and nano titanium dioxide rich in hydroxyl groups on the surface is adopted as an antibacterial agent; taking beta cyclodextrin or a derivative thereof as a monomer, reacting with a cross-linking agent and nano titanium dioxide in a solvent to generate a high-molecular-weight polymer, and dialyzing, washing and drying to obtain the titanium dioxide / beta-CD polymer-based microspheres. The water-insoluble cyclodextrin polymer-based antibacterial microsphere material prepared by the invention is a titanium dioxide / beta-CD polymer-based microsphere and has the excellent characteristics of low cost, stability in water, good adsorption performance, good antibacterial performance and the like, and the preparation method of the microsphere is simple in process, high in product quality and green and environment-friendly.

Description

technical field [0001] The invention belongs to the technical field of antibacterial materials, in particular to a water-insoluble cyclodextrin polymer-based antibacterial microsphere material and a preparation method thereof. Background technique [0002] Cyclodextrin is a general term for a series of cyclic oligomers obtained by the catalyzed degradation of starch by cyclodextrin glucosyltransferase without the participation of water molecules, usually containing 6 to 12 D-pyrans. Glucose unit. Among them, β-cyclodextrin (β-CD), which contains 7 glucose units, has moderate molecular voids and low production cost, and can form complexes through host-guest interactions and some organic micro-pollutants with matching sizes and shapes, and It has the characteristics of biocompatibility, biodegradability and no pollution, and is very promising in the field of environmental management. [0003] The β-CD microspheres in the prior art have the following deficiencies: [0004] 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/30B01J20/28A01N59/16A01N25/10A01P1/00A01P3/00B01J13/02B01J13/14C02F1/28C02F1/50C02F101/34C02F101/38
CPCB01J20/24B01J20/06B01J20/28021B01J13/02B01J13/14C02F1/286C02F1/281C02F1/50A01N59/16A01N25/10B01J2220/4812B01J2220/4825B01J2220/4806B01J2220/46C02F2101/38C02F2101/34C02F2303/04Y02A50/30
Inventor 王心雨张辉谢翔荣思佳陈杰刘盛全
Owner ANHUI AGRICULTURAL UNIVERSITY
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