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Method for extracting high-purity nervonic acid from acer truncatum oil

A technology of nervonic acid and Yuanbao maple, which is applied in chemical instruments and methods, carboxylate preparation, fatty acid production, etc., can solve the problems of restricting the large-scale production of high-purity nervine acid, achieve large-scale production, low process cost, The effect of low operating temperature

Active Publication Date: 2022-08-05
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, if you want to obtain nervonic acid with a purity of 99%, you need to go through a series of steps such as column chromatography and preparative high-performance liquid chromatography, which limits the large-scale production of high-purity nervonic acid.

Method used

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  • Method for extracting high-purity nervonic acid from acer truncatum oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Yuanbao maple seed kernels are washed with water to remove residual shells, unshelled Yuanbao maple seeds and moldy grains; drying to adjust the water content of seeds to 3%, and pressing with a shaft screw press, the pressing temperature is 120 ℃, to obtain Yuanbao maple crude oil; centrifuge Yuanbao maple crude oil at 8000r / min to remove impurities to obtain Yuanbao maple seed oil;

[0058] (2) mixing absolute ethanol and Yuanbao maple seed oil in a mass ratio of 1:1, adding 10% potassium hydroxide catalyst by weight of Yuanbao maple seed oil, and reacting at 100 ° C for 4 hours;

[0059] (3) after the reaction finishes, adjust pH to 3 with 15% aqueous HCl solution, then extract twice with petroleum ether, and combine the petroleum ether layers obtained by extraction; At 70℃, under the condition of vacuum degree of 0.05Mpa, the petroleum ether was removed by evaporation, and the mixed fatty acid was obtained;

[0060] (4) the mixed fatty acids obtained in step (3...

Embodiment 2

[0064] (1) Yuanbao maple seed kernels are washed with water to remove residual shells, unshelled Yuanbao maple seeds and moldy grains; drying to adjust the water content of seeds to 2%, and pressing with a shaft screw press, the pressing temperature is 110 ℃, to obtain Yuanbao maple crude oil; centrifuge Yuanbao maple crude oil at 8000r / min to remove impurities to obtain Yuanbao maple seed oil;

[0065] (2) mixing absolute ethanol and Yuanbao maple seed oil in a mass ratio of 1:1, and adding a 7% potassium hydroxide catalyst by weight of Yuanbao maple seed oil, and reacting at 90 ° C for 5 hours;

[0066] (3) after the reaction finishes, adjust pH to 2 with 20% aqueous HCl solution, then extract twice with petroleum ether, and combine the petroleum ether layers obtained by extraction; At 80°C, under the condition of vacuum degree of 0.05Mpa, the petroleum ether was removed by evaporation, and the mixed fatty acid was obtained;

[0067] (4) the mixed fatty acids obtained in st...

Embodiment 3

[0071] (1) Yuanbao maple seed kernels are washed with water to remove residual shells, unshelled Yuanbao maple seeds and moldy grains; drying to adjust the water content of seeds to 3%, and pressing with a shaft screw press, the pressing temperature is 120 ℃, to obtain Yuanbao maple crude oil; centrifuge Yuanbao maple crude oil at 8000r / min to remove impurities to obtain Yuanbao maple seed oil;

[0072] (2) mixing absolute ethanol and Yuanbao maple seed oil in a mass ratio of 1:1, adding 7% potassium hydroxide catalyst by weight of Yuanbao maple seed oil, and reacting at 95 ° C for 5 hours;

[0073] (3) after the reaction finishes, adjust pH to 2 with 20% aqueous HCl solution, then extract twice with petroleum ether, and combine the petroleum ether layers obtained by extraction; At 80°C, under the condition of vacuum degree of 0.05Mpa, the petroleum ether was removed by evaporation, and the mixed fatty acid was obtained;

[0074] (4) the mixed fatty acids obtained in step (3)...

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Abstract

The invention relates to a method for extracting high-purity nervonic acid from acer truncatum seed oil. The method comprises the processes of molecular distillation, urea inclusion and low-temperature crystallization. The method comprises the following steps: squeezing acer truncatum kernels to obtain acer truncatum crude oil, and removing crude oil impurities to obtain acer truncatum seed oil; carrying out transesterification on the acer truncatum seed oil, acidifying and extracting to obtain mixed fatty acid; carrying out secondary molecular distillation on the mixed fatty acid under proper conditions to obtain a nervonic acid crude product with nervonic acid content of 35% or above; the nervonic acid crude product is continuously separated and purified through urea inclusion, and a secondary nervonic acid crude product is obtained; and finally, carrying out multi-stage low-temperature crystallization purification on the secondary nervonic acid crude product to obtain a high-purity nervonic acid product with the purity of more than 99%. According to the method, high-purity nervonic acid is directly extracted from the acer truncatum seed oil, the process is simple, the product purity is high, the extraction cost is low, and large-scale production can be achieved.

Description

technical field [0001] The invention belongs to the technical field of medicinal plant component extraction, and relates to a method for extracting high-purity nervonic acid from Yuanbao maple oil. Background technique [0002] Nervoic acid was first discovered to exist in the nerve tissue of the mammalian brain, so it is called nervoic acid. In 1926, nervonic acid was first extracted from sharks by Japanese researchers, so it is also known as shark acid. The chemical name of nervonic acid is cis-15-tetradecanoic acid, which is a kind of long-chain monounsaturated fatty acid, and the molecular formula is C 24 H 46 O 2 , the molecular weight is 366.6. Nervous acid is a white flaky crystal at room temperature, soluble in alcohol but insoluble in water. [0003] Nervous acid is currently recognized in the world as a natural core component that exists in the nerves and tissues of the brain, and can promote the repair of damaged nerve cells and the regeneration of special fu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/09C07C51/42C07C51/43C07C51/44C07C51/48C07C51/487C07C57/03C11B1/06C11C1/02C11C1/10
CPCC07C51/09C07C51/42C07C51/43C07C51/44C07C51/48C07C51/487C11B1/06C11C1/025C11C1/10C11C1/103C07C57/03
Inventor 任钟旗胡雄杰周智勇
Owner BEIJING UNIV OF CHEM TECH
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