Medicine for preventing and curing osteoporosis and its preparing method

A technology for osteoporosis and medicine, which is applied in the field of preparation of the medicine, can solve the problems of great difference in ingredients, weakening mineralization, bone cytotoxicity, etc., achieves convenience in taking, promotes bone formation increase, and improves male and female sex hormone levels Effect

Inactive Publication Date: 2003-06-25
姚志平 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The shortcomings are: calcium preparations only increase blood calcium, not bone formation, and the use of calcium preparations does not reduce the fracture rate; there is no oral preparation of calcitonin and the price is expensive; bisphosphonates, iprafine, etc. have obvious effects. Gastrointestinal adverse reactions, etc.; fluoride must be taken in large doses (75mg) every day to achieve effective therapeutic effects, and the therapeutic window is narrow. High dose administration will also cause toxicity to bone cells, weaken mineralization, and reduce bone subsidence rate. Side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Weigh raw materials (kg) according to the following proportioning ratio:

[0063] Rhizoma drynaria 15 Cistanche 9.5 Psoralen 9.5 Epimedium 9.0 American ginseng 5

[0064] The production method that above-mentioned each component is made into medicine of the present invention is:

[0065] Take 15 parts of Rhizoma Rhizoma Drynariae, dry and crush into 60 mesh powder; add ethanol according to the ratio of Drynaria Rhizoma Rhizoma Rhizome (kg): 55% ethanol (liter) = 1:20, soak at 8-10°C in the dark for 24 hours; then filter Remove the slag and recover the ethanol to obtain a brownish-yellow powder lump.

[0066] After drying 9.5 parts of Cistanche deserticola, crush it to a fineness of 60 meshes; add water according to the ratio of Cistanche deserticola (kg): water (liter) = 1:8, boil and extract twice, each time for 60 minutes, combine the secondary filtrates, and dry in a water bath to obtain Brown-black gum-like substance.

[0067] Dry and pulverize 9.5 parts of psora...

Embodiment 2

[0072] Weigh raw materials (kg) according to the following proportioning ratio:

[0073] Rhizoma drynaria 25.0 Cistanche 15 Psoralen 15.0 Epimedium 10.0 American ginseng 8.0

[0074] The production method that above-mentioned each component is made into medicine of the present invention is:

[0075] First get 25 parts of Drynaria fortunei, dry and pulverize to 60 mesh powder. Add ethanol according to the ratio of Rhizoma Drynariae (kg): 50% ethanol (liter) = 1:20, soak at 8-10°C in the dark for 24 hours, filter to remove residue, and recover ethanol to obtain a brownish-yellow powder block.

[0076] After freeze-drying 15 parts of Cistanche deserticola, crush it to 60 mesh. Add water according to the ratio of Cistanche deserticola (kg): water (liter) = 1:10, boil and extract twice, each time for 60 minutes, and combine the second filtrate. Water-bath dried to brown-black gum-like substance.

[0077] Dry and pulverize 15 parts of psoraleae into 60 meshes, add ethanol accord...

Embodiment 3

[0082] Weigh raw materials (kg) according to the following proportioning ratio:

[0083] Drynaria 10.0 Cistanche 6.0 Psoralen 6.0 Epimedium 6.0 American Ginseng 5.0

[0084] The production method that above-mentioned each component is made into medicine of the present invention is:

[0085]First take 10 parts of drynariae and 10 parts of fine stones (0.1--1.0CM in diameter) and put them into a drum-type medicine frying machine, stir fry and rotate for about 20 minutes, see drynaria bulge and brown in color, take out the pan and sieve out Drynaria rhizome dried and crushed to 60 mesh powder after fine stone processing. Add ethanol according to the ratio of Rhizoma Drynariae (kg): 55% (liter) = 1:15, soak at 8-10°C in the dark for 22 hours, filter to remove residue, and recover ethanol to obtain a brownish-yellow powder lump.

[0086] After freeze-drying 6 parts of Cistanche deserticola, crush them to 60 mesh. Add water according to the ratio of Cistanche (kg): water (liter) ...

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PUM

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Abstract

The medicine for preventing and treating osteoporosis is prepared with the natural plants drynaria rhizome, desert cistanche, malaytea scurfpea fruit, epimedium, American ginseng, etc. and through drying, crushing, decoction and solvent extraction, mixing, disinfection and other steps of prepare medicine powder or table. The said preparation process can maintain the biological activity of the medicine components, and the medicine can raise the sexual hormone level of the body, stimulate the osteoplast to secret collagenase, release grorth factor and cell factor, raise the activity of the osteoplast to promote the production of bone matrix, speed the bone formation process, inhibit the dynamic balance of osteoclast and thus prevent and treating osteoporosis radically.

Description

technical field [0001] The invention relates to a medicine for preventing and treating osteoporosis, specifically a new medicine prepared from plant medicine (traditional Chinese medicine). [0002] The invention also relates to a preparation method of the medicine. Background technique [0003] Osteoporosis (OPS) is a common disease of middle-aged and elderly people. It is a chronic disease that involves many people and accompanies people for many years. The morbidity, disability and mortality of fractures caused by it are increasing day by day . Due to its high disability rate and mortality rate, it brings not only the physical pain caused by fractures but also the decline in quality of life. And it requires huge medical expenses. At present, there are 200 million people suffering from osteoporosis (OPS) in the world, and its incidence rate has jumped to the seventh among various common diseases in the world. According to statistics, there are about 75 million osteopor...

Claims

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Application Information

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IPC IPC(8): A61P19/10
Inventor 姚志平
Owner 姚志平
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