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Carbonic acid type high activity partially crystallized calcium phosphate and its prepn

A crystalline calcium phosphate, high-activity technology, applied in chemical instruments and methods, phosphorus compounds, medical science, etc., can solve the problems affecting the speed and degree of hydration reaction, affecting the performance of powder, and the powder is prone to agglomeration, etc. Achieve the effect of improving reactivity and solubility, excellent reactivity and biodegradability, and good degradability

Active Publication Date: 2006-05-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, existing studies have shown that the solubility of fully crystalline calcium phosphate in the body is small, so the dissolution rate of trace elements doped in it is also small, and it is difficult to play a role in promoting osteogenesis.
[0005] The chemical precipitation method is a common method for the synthesis of calcium phosphate powder, but as L.B.Kong et al. wrote in "Co-precipitation process to prepare nano-hydroxyapatite powder" (Nanosized hydroxyapatite powders derived from coprecipitation process, Journal of Materials Science, 2002, Vol.37 , p.1131-1134) pointed out in the article that although the synthesis of calcium phosphate powder by chemical precipitation method is simpler than the process, the synthesized powder is easy to agglomerate
The formation of agglomerates will inevitably affect the performance of the powder. For example, when it is used to prepare bioceramics, it will cause uneven structure and decrease in strength; when it is used to prepare composite biomaterials, the powder will be dispersed unevenly; The speed and extent of the chemical reaction, etc.

Method used

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  • Carbonic acid type high activity partially crystallized calcium phosphate and its prepn
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  • Carbonic acid type high activity partially crystallized calcium phosphate and its prepn

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Calcium acetate (CH 3 COO) 2 Ca·H 2 O is dissolved in water, prepared into a solution with a concentration of 2.3M, and according to the molar ratio of surfactant and calcium of 0.01, sodium lauryl sulfate is added to form A solution; diammonium hydrogen phosphate (NH 4 ) 2 HPO 4 Dissolve in water and make solution B with a concentration of 0.5M; according to the molar ratio of magnesium to calcium of 0.014 and the molar ratio of strontium to calcium of 0.028, add magnesium chloride MgCl to solution A in turn 2 ·6H 2 O, strontium nitrate Sr(NO 3 ) 2 , form C solution; add sodium carbonate Na 2 CO 3 , forming D solution; according to the calcium-phosphorus molar ratio being 1.63, the C solution is quickly introduced into the constantly stirring D solution with a catheter, and potassium hydroxide KOH solution is added to adjust and maintain the pH value of the reaction solution at 12, and the reaction time is 10min. Then centrifuge the reaction product, filter it...

Embodiment 2

[0037] CaCl 2 ·6H 2 O is dissolved in water, prepared into a solution with a concentration of 0.5M, and according to the molar ratio of surfactant and calcium of 0.01, polyethylene glycol (molecular weight 6000) is added to form A solution; dipotassium hydrogen phosphate K 2 HPO 4 Soluble in water and make solution B with a concentration of 1.2M; according to the molar ratio of zinc and calcium being 0.04, the molar ratio of magnesium and calcium being 0.024, and the molar ratio of strontium and calcium being 0.046, add zinc acetate to solution A in sequence (CH 3 COO) 2 Zn, magnesium chloride MgCl 2 ·6H 2 O, strontium nitrate Sr(NO 3 ) 2 , form C solution; according to the molar ratio of carbonate and phosphorus is 0.5, add potassium carbonate K in B solution 2 CO 3 , to form D solution; according to the calcium-phosphorus molar ratio of 1.3, the C solution was slowly added dropwise to the constantly stirring D solution, and at the same time, ammonia water was added ...

Embodiment 3

[0039] Calcium acetate (CH 3 COO) 2 Ca·H 2 O was dissolved in water and prepared into a solution with a concentration of 2M. According to the molar ratio of surfactant and calcium of 0.035, hexadecyltrimethylammonium bromide (C 19 h 42 NBr), form A solution; Triammonium phosphate (NH 4 ) 3 PO 4 ·3H 2 O is dissolved in water and prepared as B solution with a concentration of 0.5M; magnesium acetate (CH 3 COO) 2 Mg·4H 2 O, form C solution; Add ammonium carbonate (NH 4 ) 2 CO 3 ·H 2 O, form D solution; According to the calcium-phosphorus molar ratio is 1.6, the C solution is quickly introduced into the constantly stirring D solution with a catheter, and sodium hydroxide solution is added to adjust and maintain the pH value of the reaction solution at 13, and the reaction time is 12h. Then the reaction product was centrifuged, pumped, washed twice with deionized water, and then washed once with absolute ethanol. Ultrasonic treatment was introduced during the washing p...

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Abstract

The present invention is carbonic acid type high activity partially crystallized calcium phosphate and its preparation. The material has the nonstoichiometric crystallization state between the crystal and amorphous substance and contains carbonate radical, Mg, Sr and Zn essential for human body bone tissue. It is prepared with water soluble phosphate and calcium salt as material and through adding carbonate, Sr salt and / or Mg salt and / or Zn salt, reaction in water solution, separating, drying and calcining reaction product to obtain carbonic acid type high activity partially crystallized calcium phosphate powder. The powder has high bioactivity, reaction activity and biodegradability, and may be used widely in replacing and repairing hard tissue.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a carbonated high-activity partially crystalline calcium phosphate powder used for human hard tissue repair and a preparation method thereof. Background technique [0002] From the source, there are three main types of bone repair materials, namely autologous bone, allogeneic bone and synthetic materials. Traditional medicine often relies on autologous and allogeneic bone grafts for bone repair. Although autologous bone is an ideal material for bone grafting, the sources of bone donors are limited, and the secondary operation brings pain to the patient and causes new damage to the donor, and there may be morphological and functional disorders in the donor area. The defect part is accurately shaped, and it takes a long time for the crawling replacement process to be implanted in the human body. Allogeneic bone has immune rejection reaction, and due to omissio...

Claims

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Application Information

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IPC IPC(8): C01B25/32A61L27/12A61L27/40
Inventor 叶建东王秀鹏王迎军
Owner SOUTH CHINA UNIV OF TECH
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