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Hormone kind anticancer medicine slow release agent

A technology of anticancer drugs and hormones, applied in the field of medicine, can solve problems such as increased tolerance and treatment failure

Inactive Publication Date: 2006-08-30
JINAN KANGQUAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, the DNA repair function in many tumor cells is significantly enhanced after hormonal anticancer drugs, which in turn leads to the enhancement of tumor cell resistance to hormonal anticancer drugs, resulting in treatment failure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Put 70 mg of polyglycolic acid and glycolic acid copolymer (PLGA, 65:35) with a peak molecular weight of 20,000-40,000 into a container, add 100 ml of dichloromethane, dissolve and mix well, then add 10 mg of doxorubicin and 20 mg of other Moxifen, shake again and dry in vacuo to remove organic solvents. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to prepare an anticancer implant containing 10% adriamycin and 20% tamoxifen. The drug release time of the anticancer implant in physiological saline in vitro is 15-20 days, and the drug release time of subcutaneous implantation in mice is 25-40 days.

Embodiment 2

[0086] The method steps of being processed into anticancer implants are the same as in Example 1, but the difference is that the contained anticancer active ingredients are:

[0087] 5-30% triptorelin, goserelin, leuprolide, anastrozole, edoxifene, milprexifen, tamoxifen, comoxifen, raloxifene, steroid Antiestrogens, anticancer stenols, 4-hydroxytamoxifen, flutamide, aminoglutethimide, piglutamide, megestrol, medroxyprogesterone, clomiphene, toremifene , letrozole, anastrozole, or exemestane with 5-30% doxorubicin hydrochloride, epirubicin, mitomycin, mitomycin C, silinomycin, actinomycin D , mitoxantrone, dactinomycin, daunorubicin, bleomycin, (hydrochloride) bleomycin, arubicin, amrubicin, detorubicin, epirubicin, Suobi Star, Carrubicin, Idarbi Star, Rhodobi Star, Liu Ruobi Star, Medobi Star, Naimorubicin, Doxorubicin, Pirarubicin, Pirarubicin, Aurubicin, Zorubicin, Loxanthraquinone, Loxoanthrone, Pyroxantrone, Tiloxantrone, Adazol, Diethoxyacetamacin, Carcinogen or new C...

Embodiment 3

[0089] Put 70 mg of polylactic acid (PLGA, 50:50) with a peak molecular weight of 15,000-25,000 into a container, add 100 ml of dichloromethane, dissolve and mix well, add 20 mg of anastrozole and 10 epirubicin, and shake again Then dry in vacuo to remove the organic solvent. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain an anticancer implant containing 20% ​​anastrozole and 10% epirubicin. The drug release time of the anticancer implant in the physiological saline in vitro is 15-20 days, and the drug release time when placed subcutaneously in mice is 25-40 days.

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PUM

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Abstract

A slow-release hormone-type anticancer medicine features that its active anticancer component is wrapped by the slow-release auxiliary to prepare the slow-release implant or injection. Said slow-release injection is composed of slow-release microballs and solvent divided into ordinary one and special one containing the suspending aid chosen from carboxymethyl cellulose sodium and mannitol.

Description

(1) Technical field [0001] The invention relates to a hormone anti-cancer drug sustained-release agent and a preparation method thereof, and belongs to the technical field of pharmaceuticals. (2) Background technology [0002] The development of many cancers is related to hormones. Therefore, the application of hormonal anticancer drugs is more effective in treating tumors, such as lung cancer, breast cancer, pancreas, ovarian cancer, endometrial cancer, prostate and colorectal cancer. [0003] Further research found that blood vessels, connective tissue, matrix proteins, fibrin and collagen in the tumor stroma not only provide scaffolds and essential nutrients for the growth of tumor cells, but also affect the delivery of chemotherapy drugs around the tumor and around the tumor. Penetration and diffusion within tumor tissue (see Netti et al. "The influence of extracellular matrix conditions on drug delivery in solid tumors" "Cancer Research" 60, pp. 2497-503 (2000) (Netti ...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K9/10A61P35/00
Inventor 孙娟孙中厚孔庆新田绍兰
Owner JINAN KANGQUAN PHARMA TECH
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