Vinorelbine Bitartrate lipsome freeze-drying powder injection and its preparation method

Abstract

The invention relates to an antineoplastic vinorelbine bitartrate liposome, its freeze-dried powder injection and preparing process, wherein the preparation comprises liposome of vinorelbine bitartrate and pharmaceutically acceptable carrying agent, the liposome of vinorelbine bitartrate contains the following constituents: vinorelbine bitartrate, phosphatide, cholesterin and vitamin E, their weight ratio being 1 : 1-100 : 1-15 : 0.01-0.05.

Description

Technical field:

[0001] The invention relates to a liposome preparation of antitumor drug vinorelbine bitartrate. Background technique:

[0002] Vinorelbine Bitartrate (common name Vinorelbine Bitartrate), is a semi-synthetic vinca alkaloid, its mechanism of action is basically the same as that of vinblastine (VLB) and vincristine (VCR), mainly by blocking The formation of microtubules during cell mitosis stops cell division at metaphase, and is a cell cycle-specific drug. Like other vinblastines, vinorelbine also inhibits amino acid back-and-forth cycling and glutathione metabolism; calmodulin-dependent Ca 甘 -ATPase activity; biological oxidation of cells and biosynthesis of nucleic acids and oils. Clinically, it is mainly used for non-small cell lung cancer, metastatic breast cancer, advanced ovarian cancer, malignant lymphoma, etc. However, after intravenous injection of the drug, the side effects are relatively large, and the common ones are bone marrow suppression, g...