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Teprenone orally disintegrating tablet prescription and its preparation method

A technology for teprenone and orally disintegrating tablets, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery. slow effect and other problems, and achieve the effect of easy popularization and simple preparation process

Inactive Publication Date: 2007-05-02
SHANTOU UNIV MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ordinary tablets need to drink water and swallow to complete the medication process. This dosage form has poor compliance for some elderly people, children, and patients who have difficulty swallowing. Its use is restricted under some special conditions (such as lack of drinking water) or poor effect. Prenone is poorly soluble in water, resulting in slow onset of oral administration in conventional tablets, possible incomplete drug release, low bioavailability and severe side effects
Although injection administration has a quick effect, it requires the assistance of medical staff, which is not convenient for patients to use and has poor compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Teprenone 5%

[0024] Dextrin 18%

[0025] Mannitol 25%

[0026] Microcrystalline Cellulose (PH302) 40%

[0027] Low-substituted hydroxypropyl cellulose (L-HPC) 8%

[0028] Aspartame 2%

[0029] Talc 1.5%

[0030] Magnesium Stearate 0.5%

[0031] The dosage form can be produced by using conventional tablet pharmaceutical equipment and prepared by a compression process. The specific preparation method is as follows: aspartame and teprenone are respectively pulverized through an 80-mesh sieve, weighed according to the prescription amount, mixed evenly, and Pass microcrystalline cellulose, mannitol, low-substituted hydroxypropyl cellulose, talc powder, and magnesium stearate through 80-mesh sieve respectively, weigh them according to the prescription amount, mix them evenly, and then mix them with aspartame-mixed tipol Mix the renone, sieve and mix, measure the content of the semi-finished product, calculate the weight of the tablet, compress the tablet, test the har...

Embodiment 2

[0034] Teprenone 6%

[0035] Microcrystalline Cellulose (PH302) 40%

[0036] Mannitol 35%

[0037] Low-substituted hydroxypropyl cellulose (L-HPC) 8%

[0038] Crospovidone (PVPP) 2.5%

[0039] Aspartame 2.5%

[0040] Strawberry flavor 2.0%

[0041] Sweet Orange Flavor 2.0%

[0042] Talc 1.5%

[0043] Magnesium Stearate 0.5%

[0044] The dosage form can be produced by conventional tablet pharmaceutical equipment and prepared by pressing technology. The specific preparation method is as follows: aspartame, strawberry essence, sweet orange essence, and teprenone are respectively crushed through an 80-mesh sieve, and the amount according to the prescription is Weigh and mix evenly, and separately pass microcrystalline cellulose, mannitol, low-substituted hydroxypropyl cellulose, and magnesium stearate through 80 mesh sieves, weigh them according to the prescription amount, mix evenly, and then mix with aspartame Mix sweet and other teprenone, sieve and mix, measure the con...

Embodiment 3

[0047] Teprenone 8%

[0048] Microcrystalline Cellulose (PH302) 38%

[0049] Mannitol 40%

[0050] Sodium Carboxymethyl Starch (CMS-Na) 3%

[0051] Stevioside 3%

[0052] Peppermint Flavor 1.5%

[0053] Strawberry flavor 2.0%

[0054] Sweet Orange Flavor 2.0%

[0055] Talc 1.5%

[0056] Magnesium Stearate 1.0%

[0057] The dosage form can be produced by conventional tablet pharmaceutical equipment and prepared by pressing process. The specific preparation method is as follows: respectively crush stevioside, strawberry essence, sweet orange essence, mint essence, and teprenone through an 80-mesh sieve. Weigh and mix evenly, and separately pass microcrystalline cellulose, mannitol, sodium carboxymethyl starch, and magnesium stearate through 80 mesh sieves, weigh them according to the prescription amount, mix evenly, and then mix with stevioside, etc. The teprenone was mixed, sieved and mixed, the content of the semi-finished product was measured, the weight of the tablet...

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PUM

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Abstract

An oral disintegrating tablet of teprenone contains teprenone, filler chosen from MCC, dextrin, lactose and mannitol, disintegrant chosen from L-HPC, PPVP, CMS-Na and their mixture, flavouring chosen from nature or artificial sweetening agent, antioxidant chosen from VC, VE and BHA, lubricant chosen from magnesium stearate, magnesium lauryl sulfate and talc powder, and flowing aid chosen from superfine silicon gel powder and talc powder. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention belongs to pharmaceutical preparations, and relates to an orally disintegrating tablet dosage form, in particular to a teprenone orally disintegrating tablet which is compressed by a direct tableting method and has an immediate release effect. Background technique: [0002] Teprenone is a new drug for the treatment of gastric mucosal lesions (erosion, bleeding, flushing, edema), acute and chronic gastritis, and gastric ulcer. Pharmacodynamic tests have confirmed that it has anti-ulcer effects, and various experimental ulcers and various experimental gastric mucosal lesions have confirmed strong anti-ulcer effects and improvement of gastric mucosal lesions. It also has the effect of increasing gastric mucosa, increasing gastric mucosal prostaglandins, increasing and improving gastric mucosal blood flow, protecting gastric mucosa, maintaining the homeostasis of gastric mucosal hyperplasia cells, and inhibiting lipid peroxidation. [0003]...

Claims

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Application Information

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IPC IPC(8): A61K31/121A61K9/20A61P1/04
Inventor 王家权董红梅于晓军吕俊耀王晋
Owner SHANTOU UNIV MEDICAL COLLEGE
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