Homologous recombination in multipotent adult progenitor cells

a multi-potent adult progenitor cell and homologous recombination technology, applied in the direction of active genetic ingredients, artificial cell constructs, gene material ingredients, etc., can solve the problems of limited cell-based therapy use, inability to provide cells for repair of other damaged tissues, and cells of the hematopoietic lineage, so as to increase or decrease the production of gene products.
US20060228798A1Inactive Publication Date: 2006-10-12ABT HOLDING COMPANY +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ABT HOLDING COMPANY
Publication Date
2006-10-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and / or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.
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Description

RELATED APPLICATIONS

[0001] This application claims the benefit of priority to U.S. application Ser. No. 60 / 429,631, filed on Nov. 27, 2002. This application makes reference to International Application No. PCT / US00 / 21387, filed Aug. 4, 2000 and to International Application No. PCT / US02 / 04652, filed Feb. 14, 2002, both of which are hereby incorporated by reference. Each document cited or referenced in each of the foregoing applications, and any manufacturer's instructions or catalogues for any products cited or mentioned in each of the foregoing applications and in any of the cited documents, are hereby incorporated herein by reference. Furthermore, all documents cited in this text, and all documents cited or referenced in documents cited in this text, and any manufacturer's instructions or catalogues for any products cited or mentioned in this text or in any document incorporated into this text, are incorporated herein by reference. Documents incorporated by reference into this tex...

Claims

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