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Modulators of the gpr119 receptor and the treatment of disorders related thereto

a technology of gpr119 receptor and gpr119 agonist, which is applied in the direction of drug composition, extracellular fluid disorder, metabolic disorder, etc., can solve the problems of not producing insulin, not efficiently using, and not moving glucose into their cells, so as to and increase the secretion of incretin

Inactive Publication Date: 2021-11-04
ARENA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes compounds, methods, compositions, uses, and pharmaceutical products that can increase the secretion of an incretin by modulating the activity of a GPR119 receptor. This can be used to treat various disorders such as low bone mass, neurological disorders, metabolic-related disorders, and obesity. The technical effect of the patent is to provide new ways to increase incretin secretion and treat related disorders.

Problems solved by technology

However, people who have diabetes either do not produce insulin or can not efficiently use the insulin they produce; therefore, they can not move glucose into their cells.
Glucose accumulates in the blood creating a condition called hyperglycemia, and over time, can cause serious health problems.
NIDDM is characterized by a relative disparity between endogenous insulin production and insulin requirements, leading to elevated blood glucose levels.
In addition, the onset can be insidious or even clinically inapparent, making diagnosis difficult.
Kidney disease, also called nephropathy, occurs when the kidney's “filter mechanism” is damaged and protein leaks into urine in excessive amounts and eventually the kidney fails.
Diabetes is also a leading cause of damage to the retina at the back of the eye and increases risk of cataracts and glaucoma.
Finally, diabetes is associated with nerve damage, especially in the legs and feet, which interferes with the ability to sense pain and contributes to serious infections.
However, after several decades, β cell function deteriorates and non-insulin-dependent diabetes develops in about 20% of the obese population (Pederson, P.
However, the factors which predispose a fraction of patients to alteration of insulin secretion in response to fat accumulation remain unknown.
There are problems with this definition, such as, it does not take into account the proportion of body mass that is muscle in relation to fat (adipose tissue).
As the BMI increases there is an increased risk of death from a variety of causes that is independent of other risk factors.
Obesity considerably increases the risk of developing cardiovascular diseases as well.
Thrombosis subsequent to atherosclerosis leads to myocardial infarction and stroke.
Osteoporosis is a disabling disease characterized by the loss of bone mass and microarchitectural deterioration of skeletal structure leading to compromised bone strength, which predisposes a patient to increased risk of fragility fractures.
One in three women older than 50 years will have an osteoporotic fracture that causes a considerable social and financial burden on society.
Osteoporotic fractures therefore cause substantial mortality, morbidity, and economic cost.
The inflammation can cause pain and can make the intestines empty frequently, resulting in diarrhea.
The inflammation causes the colon to empty frequently resulting in diarrhea.
However, current GIP peptide agonists suffer from a lack of oral bioavailability, negatively impacting patient compliance.
Current GLP-1 peptide agonists suffer from a lack of oral bioavailability, negatively impacting efficacy.

Method used

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  • Modulators of the gpr119 receptor and the treatment of disorders related thereto
  • Modulators of the gpr119 receptor and the treatment of disorders related thereto
  • Modulators of the gpr119 receptor and the treatment of disorders related thereto

Examples

Experimental program
Comparison scheme
Effect test

example 1.1

of 5-Fluoropyrimidine-4,6-diol

Method A

[0431]To a three-neck round-bottom flask equipped with an overhead stirrer, nitrogen flow, and reflux condenser, was added 25 wt % sodium methoxide in methanol (950 mL, 4.15 mol) and formamide (357 mL, 8.98 mol). The mixture was heated to about 64° C. To the reaction mixture was added diethyl 2-fluoromalonate (177 mL, 1.12 mol) using an addition funnel over 1 h. The reaction temperature was maintained at 64° C. for 72 h. The reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The residue was cooled to 0° C. and slowly acidified with concentrated hydrochloric acid to pH 1-2 resulting in the precipitation of the product. The product was filtered and washed with an ice cold aqueous 1 N HCl solution. The off-white solid was suspended in acetonitrile, filtered and dried in a vacuum oven to give 5-fluoropyrimidine-4,6-diol (170 g, 1.31 mol) as a light brown-pinkish solid which was used without f...

example 1.2

of 4,6-Dichloro-5-fluoropyrimidine

Method A

[0433]To a 500 mL three-neck round-bottom flask containing phosphorus oxychloride (45.3 mL, 487 mmol) was slowly added 5-fluoropyrimidine-4,6-diol (20.0 g, 154 mmol) and the resulting reaction mixture was heated to 60° C. To the resulting slurry was slowly added N,N-dimethylaniline (42.2 mL, 331 mmol) over 4 h using a syringe pump and the reaction mixture was stirred at 60° C. for 16 h. The reaction mixture was cooled to room temperature and slowly added into a mixture of brine and ice (400 ml) with stirring. The aqueous layer was extracted with dichloromethane (2×250 mL). The combined organic layers (light amber) were washed with cold aqueous 6 N HCl solution (200 mL), dried over sodium sulfate, and filtered through a glass fiber paper by vacuum filtration and the solvent was removed under reduced pressure (no heat) to give 4,6-dichloro-5-fluoropyrimidine (13 g, 78 mmol, 50.6% yield) as an amber oil. 1H NMR (400 MHz, CDCl3) δ ppm 8.62 (s, 1...

example 1.3

of 2-Fluoro-2-methylpropanenitrile

Method A

[0435]To a 1 L three-neck round-bottom flask containing 2-hydroxy-2-methylpropanenitrile (120 mL, 1.31 mol) at 4° C. was slowly added (diethylamino)sulfur trifluoride (DAST) (172 mL, 1.31 mol) over 1 h via an additional funnel. The reaction mixture was allowed to warm to room temperature and stirred overnight. The mixture was directly purified by vacuum distillation (40-45° C. / 45 mmHg) to provide 2-fluoro-2-methylpropanenitrile (83.36 g, 0.957 mol, 73.0% yield) as a colorless oil containing methacrylonitrile (˜10%). 1H NMR (400 MHz, CDCl3) δ ppm 1.77 (d, J=20 Hz, 6H).

Method B

[0436]2-Hydroxy-2-methylpropanenitrile (CAS #75-86-5, 221 mL, 2.420 mol) was cooled down to −10° C. (ice / acetone / dry ice) in a 1 L three necked round bottomed flask and DAST (246 mL, 1.861 mol) was added slowly using an addition funnel over a period of 2 h. Once the addition was finished, the reaction was allowed to warm up to room temperature and stirred overnight. The ...

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Abstract

The present invention relates to the GPR119 receptor agonists: 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzanide; -fluoro-4-(5-fluoro-6-(4-(3-(2-fluoro-propan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide; and 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)benzamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as a single pharmaceutical agent or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of, for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing secretion of an incretin; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto.

Description

FIELD OF THE INVENTION[0001]The present invention relates to the GPR119 receptor agonists: 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-dimethylbenzamide; 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide; and 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)benzamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as a single pharmaceutical agent or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of, for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasin...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D413/14A61K31/506A61K45/06
CPCC07D413/14A61K45/06A61K31/506A61P1/02A61P3/00A61P3/04A61P3/06A61P3/10A61P5/48A61P5/50A61P7/00A61P9/00A61P9/10A61P9/12A61P13/12A61P19/00A61P19/02A61P19/08A61P19/10A61P25/02A61P25/08A61P25/14A61P25/16A61P25/28A61P27/02A61P27/12A61P29/00
Inventor JONES, ROBERT M.LEHMANN, JUERGCHEN, WEICHAOEDWARDS, JEFFREYMARQUEZ, GLENMORGAN, MICHAEL E.SADEQUE, ABU J.M.KIM, SUN HEE
Owner ARENA PHARMA
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