7 results about "Acetyl-L-carnitine" patented technology

The application discloses a kind of high adhesion hydrogel for electroencephalogram test and its preparation method and application, belong to biomedical engineering technical field.The hydrogel includes the following components crosslinked product: anionic monomer, cationic monomer, monomer and mutual penetration agent;The anionic monomer is any one of malic acid, gluconic acid, citric acid and lactic acid, cationic monomer is betaine or acetyl L-carnitine, monomer is N, N-dimethyl acrylamide, acrylic acid, sodium acrylate, 4-acryloyl morpholine or sodium acrylamidomethyl propane sulfonate, mutual penetration agent is sodium chloride aqueous solution or sodium chloride water-retaining agent solution.Preparation, cationic monomer is mixed and dissolved, vacuum drying, adding photo initiator mixing, then mutual penetration agent is added, and it is obtained by ultraviolet light crosslinking.The hydrogel of the application has high adhesion (adhesion strength reaches 203.22 kPa), high ion mobility and excellent biocompatibility, and the signal gain in EEG and ECG test reaches 2-3 times of traditional conductive paste, which can be widely used in medical conductive paste field.

A moisture-proof acetyl-L-carnitine, comprising not less than 10% of acetyl-L-carnitine, or a hydrochloride thereof, or a mixture of both by weight. The preparation method comprises mixing the following components by prescription amount: acetyl-L-carnitine, or a hydrochloride thereof, or a mixture of both, one or more adjuvants selected from microcrystalline cellulose, compressible starch, lactose or mannitol, one or more adjuvants selected from silicon dioxide, magnesium stearate, calcium hydrogen phosphate, calcium silicate, and micro-powder silica gel; granulating; obtaining the moisture-proof acetyl-L-carnitine. The moisture-proof acetyl-L-carnitine is formulated into a nutritional supplement, a food, a beverage, or an animal feed.

The embodiment of the invention discloses a female donkey pregnancy hyperlipemia diagnosis biomarker as well as a detection method and application thereof, and belongs to the technical field of female donkey pregnancy hyperlipemia diagnosis. The biomarker is selected from one or more of acetyl L-carnitine, glyceryl monostearate (16: 0 / 0: 0 / 0: 0) and lysophosphatidylcholine (16: 0 / 0: 0). Non-target metabonomics research on female donkey pregnancy hyperlipemia serum is carried out through ultrahigh pressure liquid phase tandem time-of-flight mass spectrometry, and serum acetyl L-carnitine, glycerin monostearate (16: 0 / 0: 0 / 0: 0) and lysophosphatidylcholine (16: 0 / 0: 0) and a combination of the serum acetyl L-carnitine, the glycerin monostearate and the lysophosphatidylcholine have relatively good diagnostic value on female donkey pregnancy hyperlipemia; the method has the advantages of low biomass of the required detection sample, simplicity, rapidness, high precision and accurate and reliable result, can distinguish the hyperlipemia of the pregnant female donkey with high sensitivity and specificity, and improves the breeding efficiency of the female donkey.

The invention discloses a crystal form A of acetyl L-carnitine hydrochloride, a preparation method of the crystal form A, and a bulk drug, a food additive, a feed additive and a composition containing the crystal form A. The crystal form A of the acetyl L-carnitine hydrochloride is good in solubility, high in stability, high in purity, regular in shape and suitable for being applied to bulk drugs, food additives and feed additives. The preparation method is simple in process, the crystal form A can be obtained at high yield through in-situ crystallization of a reaction solution and dispersion of ethanol, and the preparation method is suitable for large-scale industrial production.

The invention provides a composition for improving type 2 diabetes mellitus complicated with depression as well as a preparation method and application of the composition, and relates to the technical field of medicines. The composition comprises the following components: a coptis chinensis extract, a hawthorn leaf extract, L-carnitine, acetyl L-carnitine and inulin. The coptis chinensis is subjected to first-time enzymolysis by using a compound enzyme 1, and then is subjected to second-time enzymolysis by using a compound enzyme 2; and after enzymolysis, performing ultrasonic-assisted extraction by using an ethanol solution to obtain the coptis chinensis extract. Carrying out first enzymolysis on the hawthorn by using a compound enzyme 3, and then carrying out second enzymolysis by using a compound enzyme 4; and after enzymolysis, carrying out microwave-assisted extraction by using an ethanol solution to obtain the hawthorn leaf extract. The composition has a synergistic effect of all the components in the aspects of improving the glucose metabolism function and depression behavioristics, can effectively reduce fasting blood glucose, insulin resistance indexes and glycosylated hemoglobin, increase the sweet water preference rate and shorten the immobility time of forced swimming and tail suspension experiments, and has a better effect of treating diabetes mellitus complicated with depression.

A moisture-proof acetyl L-carnitine, comprising not less than 10% of acetyl L-carnitine by weight, or a hydrochloride thereof, or a mixture of both. A preparation method therefor comprises: mixing the following components according to a formula amount: acetyl L-carnitine, or a hydrochloride thereof or a mixture of both; one or more auxiliary materials selected from microcrystalline cellulose, compressible starch, lactose or mannitol; and one or more auxiliary materials selected from silicon dioxide, magnesium stearate, calcium hydrophosphate, calcium silicate and micronized silica gel; and granulating same to obtain a moisture-proof acetyl L-carnitine. The moisture-proof acetyl L-carnitine is formulated into a nutritional supplement, a food, a beverage or an animal feed.

The present invention belongs to the technical field of pharmaceutical chemistry, and specifically discloses a preparation method of acetyl-L-carnitine hydrochloride. The method comprises the following steps: using L-cyanoacetamide as a raw material, adding glacial acetic acid, water, potassium permanganate and sodium nitrite thereto, reacting at 40-50 °C for 1-4 h, then dropping acetyl chloride, heating up to 118-130 °C and reacting for 1-4 h, concentrating under reduced pressure to obtain acetyl-L-carnitine amide chloride; adding absolute ethanol and a certain amount of 36 wt% concentrated hydrochloric acid, reacting at 20-60 °C for 0.5-2.5 h, cooling for crystallization, filtering to obtain an ethanol solution of acetyl-L-carnitine hydrochloride; adding absolute ethanol to make the mass percentage concentration of ethanol in the ethanol solution reach 85%-95%, heating for dissolution, cooling for crystallization, filtering, and drying under vacuum to obtain pure acetyl-L-carnitine hydrochloride. The reaction conditions in the whole process are mild, and no crotonobetaine hydrochloride impurity is generated, greatly reducing the post-treatment steps and significantly increasing the purity of the product.