68 results about "Acetyl-L-carnitine" patented technology

A dietary supplement of mitochondrial nutrients is designed for relieving stress, preventing and improving stress-related disorders, such as chronic fatigue syndrome, diabetes, age-associated cognitive dysfunction and diseases (Parkinson's and Alzheimer's disease). The supplement composition has the following nutrients: B vitamins (cyanocobalamin 2-1,000 ug, thiamin 1-1,000 mg, niacin 15-2,000 mg, pyridoxine 1-1,000 mg, Pantothenate 5-150 mg, folic acid 400-40,000 ug), alpha-tocopherol 10-800 mg, ascorbic acid 50-10,000 mg, calcium 20-2,000 mg, vitamin A 200-10,000 ug, alpha-lipoic acid 100-1,000 mg, N-acetyl cysteine 100-3,000 mg, L-carnosine 100-9,000 mg, tyrosine 100-9,000 mg, vanillin 10-100 mg, phosphatidylserine 10-800 mg, resveratrol 10-50 mg, dehydroepiandrosterone 1-50 mg, and melatonin 0.1-3 mg, all of which have been individually used experimentally or clinically for relieving stress, preventing and treating age- and stress-related disorders and diseases but no combination of these compounds has been used. Many embodiments also contain at least one adjunct ingredient such as coenzyme Q 10-200 mg, acetyl-L-carnitine 100-2,000 mg, choline 50-1,000 mg, and creatine 100-2,000 mg.

The present invention relates to a nutritional supplement composition, comprising a therapeutically effective amounts of Vitamin C, Vitamin D3, Thiamin, Riboflavin, Niacin, Vitamin B6, Folic acid, Vitamin B12, Pantothenic acid, Calcium, Magnesium, Zinc, Chromium, Sugar, Protein, Acetyl-L-Carnitine, Dimethylaminoethanol complex, Phosphatidylserine complex, L-Glutamine, N-Acetyl-L-Tyrosine, L-Phenylalanine, Taurine, Methionine, Valine, Isoleucine, 5 Hydroxytryptophan, L-Taurine, N-Acetyl-Tyrosine, N-Acetyl-L-Cysteine, Alpha Lipoic Acid, Alpha Glycerylphosphoricholine complex, Bacopa Monnieri extract, Gingko Biloba extract, Passion flower, Lemon Balm, Gotu Kola, Ashwagandha, Choline Bitartrate complex, Panax Ginseng extract, Turmeric, Organic freeze dried fruit juice blends (concord grape, red raspberry, pineapple, cranberry, acai, pomegranate, acerola cherry, bilberry, lingonberry, black currant, aronia, sour cherry, black raspberry), Organic freeze dried greens blends (barley grass, broccoli, beet, carrot, alfalfa, oat), and Protein digestive enzyme blends (Protease 4.5, peptidase, bromelain, protease 6.0, protease 3.0, L planatrum, B bifidum) in a mixture to provide optimal cognitive function.

Acetyl-L-carnitine (ALCAR) and L-carntine (LCAR) are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to enhance ALCAR and LCAR formation in germinating plant seeds. Metabolic fluxes are manipulated by germination in bioreactors to increase oxygen availability as well as provide an aseptic environment to alter carbohydrate consumption and feedback repress gluconeogenesis. Large shifts in sunflower seed fatty acid, phospholipid and high-energy metabolism change the germination environment and these metabolic changes lead to an approximate 1000-fold increase in natural LCAR and ALCAR production by the seeds. The resulting LCAR and ALCAR products from the seeds are used for treating mental health disorders including Alzheimer's disease, geriatric depression, non-geriatric depression and schizophrenia.

The present disclosure provides for a scientific formulation useful in the treatment and prevention of human and animal diseases. A biologically effective amount of each of the components of the formulation is administered to patients in pill (or capsule) form via multiple different and identifiable pills. The compounds of the formulation are segregated into different pill types, and contain various amounts of the compounds Curcumin, Genistein, Squalamine, Vitamin E, N-Acetyl-Cysteine, Methylselenocysteine, Zinc Gluconate, B Complex, Lentinen, Coenzyme Q10 Acetyl-L-Carnitine, Lipoic Acid, Resveratrol, and Vitamin C. Furthermore, Arabinoxylan and/or Peperine may be added to the various pill formulations.

The present invention relates to a culture medium suitable for mammalian cell, tissue or embryo growth in vitro in which enhancers of oxidative phosphorylation are included. These enhancers include coenzyme Q, alpha.lipoic acid, acetyl-L-carnitine, alpha.tocopherol, These products are introduced into the medium in a soluble form through the use of either a polysorbate surfactant such as Tween ™ or a preparation containing lecithin and surfactant.

Improved delivery systems and delivery methods for supporting and promoting healthy sexual function, for preventing sexual dysfunction, or for treatment of sexual dysfunction. A compositions including one or more cGMP-specific PDE5 inhibitors and/or dopaminergic agonists is administered in the form of a breath-care strip, mint or lozenge, or a food or beverage product. The cGMP-specific PDE5 inhibitor comprises an ingredient selected from the group consisting of sophoflavescenol, vardenafil, tadalafil, and sildenafil. The dopaminergic agonist comprises apomorphine. Vitex agnus-castus extract, and one or more of lipoic acid, L-Arginine, folic acid, trimethylglycine, policosanol, carnitine, biotin, and acetyl L-Carnitine may also be included in the delivery vehicle.

Depression and bi-polar depression are treated with an acetyl-L-carnitine (ALCAR), thereby avoiding unwanted side-effects exhibited by conventional antidepressant agents. ALCAR also helps prevents recurrent episodes of depression and bi-polar depression and both provides beneficial membrane phospholipid and high-energy phosphate changes in a brain of human subjects with major depressive disorders (MDD).

The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which function as free radical traps such as phenyl butyl nitrone (PBN), free radical scavengers, such as edaravone, resveratrol, ebselen and iron chelator and compounds from the family of antioxidant compounds including, but not limited to, N-acetylcysteine (NAC), Acetyl-L-Carnitine (ALCAR), glutathione monoethylester, ebselen, D-methionine and carbamathione. The compositions of the current invention may be delivered by injections or orally.

A dietary supplemental composition composed of Acetyl-L-Carnitine, Phosphatidylserine, L-Alpha-Glycerylphosphorylcholine, fish oils including Docosahexaenoic acid, Alpha Lipoic Acid, and optionally Eicosapentaenoic acid, and which in combination has been demonstrated to be effective in increasing cognitive performance, elevating mood and decreasing oxidative stress levels in mammals.

The invention discloses a preparation method for acetyl-L-carnitine nitrate, and belongs to an acyclic compound of which the carbon skeleton is substituted by oxygen atoms. The method specifically comprises the preparation of acetyl-L-carnitine and the preparation of the acetyl-L-carnitine nitrate. According to the technical scheme, the method is simple, easy, low in cost and favorable for industrial large-scale production; the use of a catalyst during reaction is avoided, so that purification is facilitated; the method is short in reaction time and high in production efficiency; acetic acid can be recovered by adding acetone for crystallization after being evaporated under reduced pressure after reaction, and the acetone can also be recovered in a distillation way, so that the waste of a solvent is greatly reduced, and the cost is lowered; a product is qualified and high in yield.

A nutritional composition for the treatment of syndromes related to dysfunctional energy metabolism is provided. The composition comprises a combination of L-carnitine, acetyl-L-carnitine, pantothenate and niacinamide. Methods of treatment of dysfunctional energy metabolism are also disclosed.

A method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent of the family of platin compounds, taxanes, epothilone class, vinca alkaloids, said method comprising the administration in a co-ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies, an effective amount of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof. In case of prevention, acetyl L-carnitine is administered to a subject, in view of the need of a treatment with an anticancer agent, immediately before or immediately after surgical removal of the tumor, but in any case before the administration of the anticancer agent. Acetyl L-carnitine can enhance the supportive effect of physiological NGF during chemotherapy-induced neuropathy, thus avoiding the problem of the local and general side effects of the exogenous administration of NGF which are a major problem of this neuroprotective strategy.

The invention belongs to the field of assisted reproduction, in particular to a one-step embryo culture medium and a preparation method thereof. A composition for preparing the one-step embryo culturemedium is prepared from (+/-)-alphal-lipoic acid, acetyl L-carnitine or acetyl L-carnitine hydrochloride, N-acetyl-L-cysteine according to a molar ratio of (0.055 to 0.098) to (0.044 to 0.078) to (0.702 to 0.858). The one-step embryo culture medium prepared by using the composition keeps effective components secreted into the culture medium by an embryo, plays a role in protecting cells and restraining, decomposing and utilizing harmful products, and the problem of low blastocyst forming rate caused by mechanical injury in the embryo transplanting process and stress reaction due to differentculture environments is solved.

This document provides dietary supplement compositions. For example, dietary supplement compositions having an acetylcholinesterase inhibitor (e.g., huperzine A), a Bacopa monnieri extract, acetyl-L-carnitine or acetyl CoA, and a curcuminoid (e.g., curcumin) are provided.

The invention discloses a medicine for treating senile dementia. The medicine comprises the following components in parts by mass: 120-180 parts of kaempferol, 250-400 parts of rhodiola rosea, 160-200 parts of grassleaf sweelflag rhizome, 120-160 parts of ludwigia octovalvis, 80-120 parts of rhodiola rosea, 30-60 parts of lumbricus peptide, 8-20 parts of acetyl-L-carnitine, 800-1200 parts of radix gaulophylli and 10-14 parts of leonurus. An applicant obtains a scientific and reasonable medicine formula for treating the senile dementia by great experimental researches. The invention belongs to treatment of the senile dementia by using the kaempferol for the first time. After various medicines are combined, the efficacy of the medicines is matched, so that the medicine can treat the senile dementia caused by various reasons, and is good in effect and rapid in effect taking.

A nutritional supplement for increasing cognitive functioning. The supplement includes a flavonoid such as luteolin and a labdane diterpene such as forskolin. The supplement can also include one or any combination of L-phenylalanine, L-carnitine, acetyl-L-carnitine, and vitamin B6. Artichoke extract can be used as a source of luteolin. Methods of using the nutritional supplements to increase cognitive functioning are also included.

The invention relates to a medicine for curing male infertility. L-carnitine, acetyl-L-carnitine, a selenium source additive, a zinc source additive, folic acid, taurine, rhizoma polygonati, herba epimedii, fructus lycii, cordyceps militaris, raspberries and the like are used as raw materials and are appropriately proportioned; the L-carnitine, acetyl-L-carnitine, selenium source additive, zinc source additive and amino acids are beneficial for strengthening spermic energy metabolism, increasing the amount of sperms and improving the activity of the sperms; the taurine, astaxanthin and vitamin C have the effect of effectively removing reactive oxide species to protect the activity of the sperms; the folic acid can promote the maturity of the sperms and compete the functions of the sperms; and the rhizoma polygonati, herba epimedii, fructus lycii, cordyceps militaris, raspberries and cubilose have the effects of invigorating spleen, replenishing qi, nourishing kidney and replenishing essence together. The medicine disclosed by the invention is reasonable in composition and obvious in curative effect, can be applicable to treatment requirements of complex diseases, reaches the effects of comprehensive treatment and comprehensive conditioning, and is effective medicine for curing male infertility caused by various reasons.

Acetyl L-carnitine, or of one of its pharmaceutically acceptable salts, is useful for the prevention of painful peripheral neuropathy in patients suffering from type 2 diabetes, in which symptoms are pain, paraesthesia or hyperaesthesia. The acetyl L-carnitine is administered orally at a dose of at least 3 grams/day.

A composition for the treatment of “Burning Feet Syndrome” includes pantothenic acid or its analogs, or its derivatives, or its synonyms, alpha-lipoic acid or its analogs, or its derivatives, or its synonyms, and L-arginine or its analogs, or its derivatives, or its synonyms. The composition may also include at least one substance selected from the group consisting of B1, B2, B3, B6, B7, B9, B12, Acetly-L-Carnitine, N-acetlycystein, Omega-3 fatty acids, Omega-6 fatty acids, Vitamin E, and Taurine or any of their analogs, derivatives, or synonyms. The composition is used in a method for the treating of “Burning Feet Syndrome” by administering to a human such a composition.

The invention belongs to the field of assisted reproduction, and particularly relates to a one-step embryo culture solution and a preparation method thereof. A composition for preparing the one-step embryo culture solution is prepared from (+/-)-alpha-lipoic acid, acetyl L-carnitine or acetyl L-carnitine hydrochloride, wherein a molar ratio of the (+/-)-alpha-lipoic acid to the acetyl L-carnitineor the acetyl L-carnitine hydrochloride is (0.055 to 0.098) : (0.044 to 0.078). The one-step embryo culture solution prepared by utilizing the composition has the advantages that effective componentssecreted into the culture solution by embryo are retained, the effects of protecting cells, inhibiting the decomposition and utilizing harmful products are achieved, and possible mechanical damage inthe process of embryo transfer is avoided; in addition, the problem of low formation rate of blastocyst caused by stress response due to different culture environments is solved.

Symptoms of fibromyalgia are treated by daily administration of a regiment comprising a combination of naturally occurring ingredients selected from a group consisting of turmeric extract, boswellia extract, dandelion root, grape seed extract, green tea, a bioflavonoid complex, acetyl L-carnitine, and vitamin B12. Such ingredients are generally safe for human consumption and, when used in combination, relieve the symptoms associated with fibromyalgia.

The invention provides a biomarker for diabetes diagnosis and application thereof. Specifically, the invention provides a biomarker set, and the biomarker set comprises one or more of acetyl L-carnitine, trimethylamine oxide and choline chloride. The acetyl-L-carnitine is applied to diagnosis of diabetes for the first time. Through verification, when the acetyl-L-carnitine is used for diagnosing and distinguishing a diabetic patient and a healthy person, the AUC reaches 0.8 or above, and when the two indexes of the acetyl-L-carnitine and choline chloride are jointly used, the AUC is closer to 1 than a single index, and the diagnosis effect is better; when the three indexes of acetyl-L-carnitine, trimethylamine oxide and choline chloride are jointly applied, the AUC is closer to 1 than that of a single index and two indexes which are jointly applied, and the diagnosis distinguishing effect is the best. Diabetes can be accurately diagnosed with high specificity and high sensitivity by detecting the biomarker provided by the invention.