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3results about "Neurotensin" patented technology
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Chimeric polypeptides and uses thereof
The present invention relates to a nucleic acid molecule encoding a chimeric polypeptide comprising a peptide of interest fused to one or more heterologous moieties, wherein at least one of the heterologous moieties is a ligand of the Sortilin receptor. The invention also relates to a chimeric polypeptide encoded by said nucleic acid molecule and uses thereof.
Owner:GENETHON +3
Methods and sortilin binding conjugate compounds for targeting cancer stem cells
PendingEP4297795A4Organic active ingredientsCell receptors/surface-antigens/surface-determinantsCancer targetingBiochemistry
The present application relates to methods and uses of conjugates comprising antitumor agents (e.g., chemotherapeutic agents) conjugated to peptide compounds targeting Sortilin-expressing cancer stem cells (CSCs), in embodiments for the treatment of poor prognosis cancers refractory to standard antitumor therapies associated the presence of Sortilin-expressing CSCs, and for preventing or treating cancer relapse or recurrence.
Owner:TRANSFERT PLUS SEC +1
Human blood-brain barrier targeting antibodies
PendingUS20260062480A1Antibody mimetics/scaffoldsAntibody ingredientsAntigenAntigen Binding Fragment
The present invention provides antibodies or antigen-binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to and translocate the blood-brain barrier and methods of use.
Owner:WISCONSIN ALUMNI RES FOUND