4results about How to "Avoid serious complications" patented technology

The application provides a construction system and device of a non-human animal model of tension pneumothorax, and the system comprises: a fixing unit for fixing the non-human animal; a first processing unit for puncturing a puncture needle to the parietal pleura, making a guide wire pass through the needle cavity of the puncture needle to enter the pleural cavity, and withdrawing the puncture needle; a second processing unit for inserting a catheter along the guide wire to make the catheter enter the pleural cavity, pulling out the guide wire, and fixing the catheter; a third processing unit for unidirectional air injection into the pleural cavity through the catheter; and a fourth processing unit for monitoring the range of pneumothorax, determining that the non-human animal model of tension pneumothorax is obtained when the lung sliding of the injection side chest is greater than or equal to 4 / 6 area and lung points are observed, stopping air injection, and obtaining the non-human animal model of tension pneumothorax. The construction success rate of the application is 100%, the construction process is rapid, repeatable and objective in determination, and the application can provide a rapid and repeatable platform for diagnostic research, decompression technology evaluation and training.

This invention discloses a primer set and kit for detecting gene variant sites in glucose-6-phosphate dehydrogenase (G6PD) deficiency, belonging to the field of gene detection technology. The primer set includes multiplex PCR amplification primers shown in SEQ ID NO. 1–14 and single-base extension primers shown in SEQ ID NO. 15–35, capable of simultaneously detecting 21 G6PD pathogenic variant sites (including high-incidence sites in the Chinese population such as c.95A>G and c.202G>A). The kit also includes PCR amplification reaction reagents, SAP enzymatic digestion reaction reagents, extension reaction reagents, desalting resin, and a detection chip. The detection method employs “multiplex PCR amplification → SAP dephosphorylation → single-base extension → nucleic acid mass spectrometry detection,” automatically determining the genotype based on mass-to-charge ratio differences. This invention offers comprehensive site coverage (covering pathogenic mutations in over 99% of Chinese patients), high accuracy (100% consistent with Sanger sequencing results), ease of operation (automatic detection and result analysis), and suitability for small sample sizes. It can be applied to prenatal diagnosis and newborn genetic disease screening, and is suitable for large-scale promotion in hospitals at all levels, providing a reliable tool for rapid and accurate detection of G6PD deficiency.

The invention discloses an intracranial pressure monitor with a trend prediction function, and belongs to the field of medical monitoring equipment. The monitor solves the problems that an existing intracranial pressure monitoring device is lack of prospective prediction capacity and cannot warn abnormal changes of the intracranial pressure in advance. Comprising the steps that an acquisition processing module acquires intracranial pressure time sequence data in real time and performs filtering and denoising processing; the trend prediction module predicts an intracranial pressure change trend in a future preset time window through an embedded intelligent algorithm based on the intracranial pressure time sequence data; and the interface display module explicitly outputs the prediction result of the intracranial pressure change trend. The trend prediction module adopts a lightweight prediction model, realizes local reasoning through algorithms such as a long-short-term memory network, a gating circulation unit and a gradient boosting tree model after fixed-point quantization, and outputs rising, stable or falling trend categories. The monitor can provide prospective early warning when the intracranial pressure value does not exceed a clinical threshold value, and safety and effectiveness of monitoring of neurological critical patients are improved.

The embodiment of the invention provides an impact waveguide wire and an impact wave generating device, and relates to the technical field of medical instruments. The impact waveguide wire comprises a guide wire body, an impact wave generating unit, a guide wire head end assembly and an expansion locking mechanism. The guide wire body is provided with a near end and a far end. The shock wave generating unit is arranged on the guide wire body; the guide wire head end assembly comprises a head end body and an impact head, and the head end body is connected with the far end of the guide wire main body; the head end body and the impact head are operably connected through an expansion locking mechanism, and the expansion locking mechanism is configured to be capable of being switched between a locking state and an unlocking state; in the locking state, the expansion locking mechanism acts on the impact head, so that the impact head and the head end body form mechanical interlocking and friction fixation; and in the unlocking state, the expansion locking mechanism relieves the action on the impact head, so that the impact head is separated from or flexibly connected with the guide wire main body, and the impact head is allowed to be separated from the guide wire main body. The blood vessel can be efficiently opened, and meanwhile safety is considered.